BRD-K07691486_roscovitine_A375_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

126 genes differentially expressed following the BRD-K07691486_roscovitine_A375_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
AKR1C3 aldo-keto reductase family 1, member C3
ASPN asporin
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BEX4 brain expressed, X-linked 4
BST2 bone marrow stromal cell antigen 2
C14ORF132 chromosome 14 open reading frame 132
CELF2 CUGBP, Elav-like family member 2
CFB complement factor B
CFI complement factor I
CYBA cytochrome b-245, alpha polypeptide
CYBRD1 cytochrome b reductase 1
EFNA1 ephrin-A1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB2 erb-b2 receptor tyrosine kinase 2
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GRAMD1C GRAM domain containing 1C
GSTA1 glutathione S-transferase alpha 1
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DRA major histocompatibility complex, class II, DR alpha
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
ISG15 ISG15 ubiquitin-like modifier
KRT23 keratin 23, type I
MAGED1 melanoma antigen family D1
MAGED2 melanoma antigen family D2
MAPT microtubule-associated protein tau
MATN2 matrilin 2
MEF2C myocyte enhancer factor 2C
METTL7A methyltransferase like 7A
MSRB2 methionine sulfoxide reductase B2
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NRIP1 nuclear receptor interacting protein 1
OBSL1 obscurin-like 1
OPTN optineurin
ORAI3 ORAI calcium release-activated calcium modulator 3
PBLD phenazine biosynthesis-like protein domain containing
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDGFC platelet derived growth factor C
PDZK1IP1 PDZK1 interacting protein 1
PEG3 paternally expressed 3
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PGAP3 post-GPI attachment to proteins 3
PHYH phytanoyl-CoA 2-hydroxylase
PLA2G16 phospholipase A2, group XVI
PLSCR4 phospholipid scramblase 4
PTN pleiotrophin
PXDN peroxidasin
QPRT quinolinate phosphoribosyltransferase
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
REEP1 receptor accessory protein 1
RPS27L ribosomal protein S27-like
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC22A18 solute carrier family 22, member 18
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SOX2 SRY (sex determining region Y)-box 2
SSBP2 single-stranded DNA binding protein 2
TPP1 tripeptidyl peptidase I
TRIM22 tripartite motif containing 22
VAT1 vesicle amine transport 1
WBP1L WW domain binding protein 1-like

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
AMD1 adenosylmethionine decarboxylase 1
ANOS1 anosmin 1
AQP3 aquaporin 3 (Gill blood group)
BAZ1A bromodomain adjacent to zinc finger domain, 1A
CAMP cathelicidin antimicrobial peptide
CCL5 chemokine (C-C motif) ligand 5
CCND1 cyclin D1
CD2 CD2 molecule
CDC25A cell division cycle 25A
CRLF1 cytokine receptor-like factor 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DENND2D DENN/MADD domain containing 2D
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNM1L dynamin 1-like
DUSP2 dual specificity phosphatase 2
EIF1AX eukaryotic translation initiation factor 1A, X-linked
ELANE elastase, neutrophil expressed
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHA2 EPH receptor A2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAS Fas cell surface death receptor
FOSL1 FOS-like antigen 1
GEM GTP binding protein overexpressed in skeletal muscle
GSPT1 G1 to S phase transition 1
HES1 hes family bHLH transcription factor 1
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
INHBA inhibin, beta A
JAG1 jagged 1
KRT5 keratin 5, type II
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LYZ lysozyme
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NFIB nuclear factor I/B
NRGN neurogranin (protein kinase C substrate, RC3)
ODC1 ornithine decarboxylase 1
PDLIM5 PDZ and LIM domain 5
PKP1 plakophilin 1
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLAU plasminogen activator, urokinase
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PRF1 perforin 1 (pore forming protein)
RGS4 regulator of G-protein signaling 4
S100A2 S100 calcium binding protein A2
SFN stratifin
SFTPB surfactant protein B
STX1A syntaxin 1A (brain)
TACSTD2 tumor-associated calcium signal transducer 2
TGM2 transglutaminase 2
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta