BRD-K07691486_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

127 genes differentially expressed following the BRD-K07691486_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKAP8L A kinase (PRKA) anchor protein 8-like
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
AREG amphiregulin
ARL4C ADP-ribosylation factor-like 4C
BEX4 brain expressed, X-linked 4
CCL8 chemokine (C-C motif) ligand 8
CLEC2B C-type lectin domain family 2, member B
CPE carboxypeptidase E
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDB2 damage-specific DNA binding protein 2, 48kDa
DFNA5 deafness, autosomal dominant 5
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
EMP1 epithelial membrane protein 1
ESR1 estrogen receptor 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FHL1 four and a half LIM domains 1
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GBP1 guanylate binding protein 1, interferon-inducible
GBP2 guanylate binding protein 2, interferon-inducible
GJA1 gap junction protein, alpha 1, 43kDa
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST2H2BE histone cluster 2, H2be
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IDO1 indoleamine 2,3-dioxygenase 1
IER5 immediate early response 5
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL32 interleukin 32
ITM2A integral membrane protein 2A
JAG1 jagged 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP10 matrix metallopeptidase 10
MN1 meningioma (disrupted in balanced translocation) 1
MYRF myelin regulatory factor
PEG3 paternally expressed 3
PELI1 pellino E3 ubiquitin protein ligase 1
PNMAL1 paraneoplastic Ma antigen family-like 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRNP prion protein
PSAP prosaposin
RAP2C RAP2C, member of RAS oncogene family
SCUBE2 signal peptide, CUB domain, EGF-like 2
SESN1 sestrin 1
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPON1 spondin 1, extracellular matrix protein
TM4SF1 transmembrane 4 L six family member 1
TUFT1 tuftelin 1
TXNL4B thioredoxin-like 4B
WARS tryptophanyl-tRNA synthetase

decreased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
ADGRG2 adhesion G protein-coupled receptor G2
ADI1 acireductone dioxygenase 1
ANKRD36B ankyrin repeat domain 36B
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATF5 activating transcription factor 5
AURKA aurora kinase A
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CENPF centromere protein F, 350/400kDa
CEP55 centrosomal protein 55kDa
CNOT7 CCR4-NOT transcription complex, subunit 7
CREB1 cAMP responsive element binding protein 1
DCN decorin
DEFB1 defensin, beta 1
DEPDC1 DEP domain containing 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNM1L dynamin 1-like
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
GABPB1 GA binding protein transcription factor, beta subunit 1
GNAS GNAS complex locus
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
HMGB1 high mobility group box 1
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXC10 homeobox C10
HOXC6 homeobox C6
HP haptoglobin
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
INTS3 integrator complex subunit 3
IRS2 insulin receptor substrate 2
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
LXN latexin
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MSRB1 methionine sulfoxide reductase B1
MYO6 myosin VI
NEK2 NIMA-related kinase 2
NPR3 natriuretic peptide receptor 3
NR2F2 nuclear receptor subfamily 2, group F, member 2
NREP neuronal regeneration related protein
OPN3 opsin 3
PIGB phosphatidylinositol glycan anchor biosynthesis, class B
PLK1 polo-like kinase 1
PRC1 protein regulator of cytokinesis 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLIT2 slit homolog 2 (Drosophila)
SLPI secretory leukocyte peptidase inhibitor
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPC25 SPC25, NDC80 kinetochore complex component
TACC3 transforming, acidic coiled-coil containing protein 3
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TBC1D31 TBC1 domain family, member 31
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TMEM100 transmembrane protein 100
TPR translocated promoter region, nuclear basket protein
UBE2S ubiquitin-conjugating enzyme E2S
ZHX2 zinc fingers and homeoboxes 2
ZWILCH zwilch kinetochore protein