BRD-K07667918_linsitinib_MCF10A_3_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

63 genes differentially expressed following the BRD-K07667918_linsitinib_MCF10A_3_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
APOD apolipoprotein D
C3 complement component 3
CD38 CD38 molecule
CFB complement factor B
CLDN1 claudin 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DEPTOR DEP domain containing MTOR-interacting protein
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FABP4 fatty acid binding protein 4, adipocyte
FBLN1 fibulin 1
GATA3 GATA binding protein 3
IL6ST interleukin 6 signal transducer
KLF5 Kruppel-like factor 5 (intestinal)
LPL lipoprotein lipase
METTL7A methyltransferase like 7A
MMP7 matrix metallopeptidase 7
NNMT nicotinamide N-methyltransferase
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NTS neurotensin
RGS1 regulator of G-protein signaling 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLPI secretory leukocyte peptidase inhibitor
SNAP25 synaptosomal-associated protein, 25kDa
SOX4 SRY (sex determining region Y)-box 4
SRGN serglycin
STOM stomatin
SYT1 synaptotagmin I
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSC22D3 TSC22 domain family, member 3
VAV3 vav 3 guanine nucleotide exchange factor

decreased expression

Symbol Name
ADM adrenomedullin
CCND2 cyclin D2
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CYR61 cysteine-rich, angiogenic inducer, 61
DSP desmoplakin
G0S2 G0/G1 switch 2
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
IGFBP5 insulin-like growth factor binding protein 5
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
KRT19 keratin 19, type I
KRT8 keratin 8, type II
LGALS2 lectin, galactoside-binding, soluble, 2
MYLK myosin light chain kinase
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
S100A10 S100 calcium binding protein A10
SDC4 syndecan 4
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
TLR4 toll-like receptor 4
TMEM45A transmembrane protein 45A
ZFP36L1 ZFP36 ring finger protein-like 1