BRD-K07667918_linsitinib_HEPG2_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

95 genes differentially expressed following the BRD-K07667918_linsitinib_HEPG2_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIPOQ adiponectin, C1Q and collagen domain containing
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ASPH aspartate beta-hydroxylase
CCL20 chemokine (C-C motif) ligand 20
CCNG2 cyclin G2
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CES1 carboxylesterase 1
CHRDL1 chordin-like 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FABP4 fatty acid binding protein 4, adipocyte
FAM129A family with sequence similarity 129, member A
FMO2 flavin containing monooxygenase 2 (non-functional)
GCLC glutamate-cysteine ligase, catalytic subunit
GPX2 glutathione peroxidase 2
GRIA2 glutamate receptor, ionotropic, AMPA 2
GSTP1 glutathione S-transferase pi 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IL7R interleukin 7 receptor
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4
KLF4 Kruppel-like factor 4 (gut)
KLHL21 kelch-like family member 21
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MAOA monoamine oxidase A
MDFIC MyoD family inhibitor domain containing
MME membrane metallo-endopeptidase
MOK MOK protein kinase
MSX1 msh homeobox 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NQO2 NAD(P)H dehydrogenase, quinone 2
PDHX pyruvate dehydrogenase complex, component X
PDZRN3 PDZ domain containing ring finger 3
PIR pirin (iron-binding nuclear protein)
PPARG peroxisome proliferator-activated receptor gamma
RBP4 retinol binding protein 4, plasma
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SFRP1 secreted frizzled-related protein 1
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPP1 secreted phosphoprotein 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SSBP2 single-stranded DNA binding protein 2
STC2 stanniocalcin 2
TALDO1 transaldolase 1
TM4SF1 transmembrane 4 L six family member 1
TMEM47 transmembrane protein 47
TRIM16 tripartite motif containing 16
TSKU tsukushi, small leucine rich proteoglycan
TXN thioredoxin
TXNRD1 thioredoxin reductase 1
UGDH UDP-glucose 6-dehydrogenase

decreased expression

Symbol Name
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CALML5 calmodulin-like 5
CD24 CD24 molecule
CNN3 calponin 3, acidic
COL1A1 collagen, type I, alpha 1
CST6 cystatin E/M
CSTA cystatin A (stefin A)
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXADR coxsackie virus and adenovirus receptor
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DLK1 delta-like 1 homolog (Drosophila)
EZR ezrin
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GRB7 growth factor receptor-bound protein 7
HBEGF heparin-binding EGF-like growth factor
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDI1 isopentenyl-diphosphate delta isomerase 1
KLK5 kallikrein-related peptidase 5
PEG3 paternally expressed 3
PLK1 polo-like kinase 1
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLPI secretory leukocyte peptidase inhibitor
SOX9 SRY (sex determining region Y)-box 9
SQLE squalene epoxidase
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TMEM45A transmembrane protein 45A
TRIB2 tribbles pseudokinase 2
VEGFA vascular endothelial growth factor A