BRD-K07667918_linsitinib_HCC515_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

80 genes differentially expressed following the BRD-K07667918_linsitinib_HCC515_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRF5 adhesion G protein-coupled receptor F5
ADIRF adipogenesis regulatory factor
BEX1 brain expressed, X-linked 1
BST2 bone marrow stromal cell antigen 2
C10ORF10 chromosome 10 open reading frame 10
C6ORF62 chromosome 6 open reading frame 62
CCL2 chemokine (C-C motif) ligand 2
CD24 CD24 molecule
CHGB chromogranin B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLU clusterin
CXCL14 chemokine (C-X-C motif) ligand 14
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
EIF5A eukaryotic translation initiation factor 5A
EZR ezrin
FZD7 frizzled class receptor 7
GNAS GNAS complex locus
HIST1H2AC histone cluster 1, H2ac
HOPX HOP homeobox
HSPA1A heat shock 70kDa protein 1A
IGFBP5 insulin-like growth factor binding protein 5
KLK10 kallikrein-related peptidase 10
LMO2 LIM domain only 2 (rhombotin-like 1)
MT1M metallothionein 1M
MUC1 mucin 1, cell surface associated
NEFL neurofilament, light polypeptide
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDGFD platelet derived growth factor D
PLIN2 perilipin 2
PPL periplakin
RAB31 RAB31, member RAS oncogene family
RALGDS ral guanine nucleotide dissociation stimulator
RAP1GAP RAP1 GTPase activating protein
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SH3YL1 SH3 and SYLF domain containing 1
SLC38A1 solute carrier family 38, member 1
TCTA T-cell leukemia translocation altered
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TPD52L1 tumor protein D52-like 1
TRIM22 tripartite motif containing 22
TRIM29 tripartite motif containing 29
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGDH UDP-glucose 6-dehydrogenase
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ABHD6 abhydrolase domain containing 6
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
COL1A1 collagen, type I, alpha 1
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EDNRA endothelin receptor type A
EFNB2 ephrin-B2
EREG epiregulin
FKBP11 FK506 binding protein 11, 19 kDa
FLRT2 fibronectin leucine rich transmembrane protein 2
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HLTF helicase-like transcription factor
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFITM3 interferon induced transmembrane protein 3
IGFBP3 insulin-like growth factor binding protein 3
IL13RA2 interleukin 13 receptor, alpha 2
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KYNU kynureninase
MAN1A1 mannosidase, alpha, class 1A, member 1
NEB nebulin
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
RBP4 retinol binding protein 4, plasma
RGS2 regulator of G-protein signaling 2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SIK1 salt-inducible kinase 1
SRSF6 serine/arginine-rich splicing factor 6
STEAP1 six transmembrane epithelial antigen of the prostate 1
STK10 serine/threonine kinase 10
TMEM45A transmembrane protein 45A
TYMS thymidylate synthetase
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28