BRD-K07303502_Arachidonyl trifluoro-methyl ketone_SW480_6.0_h_80.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

124 genes differentially expressed following the BRD-K07303502_Arachidonyl trifluoro-methyl ketone_SW480_6.0_h_80.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BAG3 BCL2-associated athanogene 3
BZW2 basic leucine zipper and W2 domains 2
CALCA calcitonin-related polypeptide alpha
CKS2 CDC28 protein kinase regulatory subunit 2
CLIC4 chloride intracellular channel 4
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
CSRP1 cysteine and glycine-rich protein 1
CTGF connective tissue growth factor
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
EIF5 eukaryotic translation initiation factor 5
FABP7 fatty acid binding protein 7, brain
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FKBP14 FK506 binding protein 14, 22 kDa
FN1 fibronectin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
HBB hemoglobin, beta
HBD hemoglobin, delta
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFI27 interferon, alpha-inducible protein 27
IFRD1 interferon-related developmental regulator 1
ITM2C integral membrane protein 2C
LIMCH1 LIM and calponin homology domains 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP7 microtubule-associated protein 7
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
NFIL3 nuclear factor, interleukin 3 regulated
NNMT nicotinamide N-methyltransferase
NR4A1 nuclear receptor subfamily 4, group A, member 1
OSER1 oxidative stress responsive serine-rich 1
PECR peroxisomal trans-2-enoyl-CoA reductase
PMP22 peripheral myelin protein 22
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RND3 Rho family GTPase 3
RPL38 ribosomal protein L38
S100B S100 calcium binding protein B
S100P S100 calcium binding protein P
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SPON2 spondin 2, extracellular matrix protein
STAT1 signal transducer and activator of transcription 1, 91kDa
SYBU syntabulin (syntaxin-interacting)
TGFBI transforming growth factor, beta-induced, 68kDa
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM41B transmembrane protein 41B
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
UGT8 UDP glycosyltransferase 8
ZFP36 ZFP36 ring finger protein
ZW10 zw10 kinetochore protein

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
AIM1 absent in melanoma 1
ALDOB aldolase B, fructose-bisphosphate
AOX1 aldehyde oxidase 1
AP2B1 adaptor-related protein complex 2, beta 1 subunit
ARL4C ADP-ribosylation factor-like 4C
AUTS2 autism susceptibility candidate 2
BMP4 bone morphogenetic protein 4
C7 complement component 7
CCL5 chemokine (C-C motif) ligand 5
CES2 carboxylesterase 2
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CXCR4 chemokine (C-X-C motif) receptor 4
DKK3 dickkopf WNT signaling pathway inhibitor 3
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ERAP2 endoplasmic reticulum aminopeptidase 2
F2R coagulation factor II (thrombin) receptor
F5 coagulation factor V (proaccelerin, labile factor)
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHL1 four and a half LIM domains 1
G0S2 G0/G1 switch 2
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11
HDGFRP3 hepatoma-derived growth factor, related protein 3
HPD 4-hydroxyphenylpyruvate dioxygenase
IKZF1 IKAROS family zinc finger 1 (Ikaros)
JAG1 jagged 1
NFIB nuclear factor I/B
NMU neuromedin U
NOX4 NADPH oxidase 4
NR2F1 nuclear receptor subfamily 2, group F, member 1
NT5E 5'-nucleotidase, ecto (CD73)
PBX3 pre-B-cell leukemia homeobox 3
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGIS prostaglandin I2 (prostacyclin) synthase
RBP4 retinol binding protein 4, plasma
RNF144A ring finger protein 144A
SFRP1 secreted frizzled-related protein 1
SLC35F2 solute carrier family 35, member F2
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAR steroidogenic acute regulatory protein
TFF1 trefoil factor 1
TFPI2 tissue factor pathway inhibitor 2
TGFBR3 transforming growth factor, beta receptor III
THAP11 THAP domain containing 11
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
VCAN versican
VNN1 vanin 1
ZNF586 zinc finger protein 586