BRD-K07303502_Arachidonyl trifluoro-methyl ketone_NCIH1836_6.0_h_80.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

157 genes differentially expressed following the BRD-K07303502_Arachidonyl trifluoro-methyl ketone_NCIH1836_6.0_h_80.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTN1 actinin, alpha 1
ADM adrenomedullin
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANXA1 annexin A1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPN asporin
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAG3 BCL2-associated athanogene 3
BTG1 B-cell translocation gene 1, anti-proliferative
C1ORF54 chromosome 1 open reading frame 54
C5AR1 complement component 5a receptor 1
CBR3 carbonyl reductase 3
CD24 CD24 molecule
CEMIP cell migration inducing protein, hyaluronan binding
COL11A1 collagen, type XI, alpha 1
COL15A1 collagen, type XV, alpha 1
COL1A1 collagen, type I, alpha 1
COL5A2 collagen, type V, alpha 2
CREM cAMP responsive element modulator
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
EPCAM epithelial cell adhesion molecule
EPRS glutamyl-prolyl-tRNA synthetase
FAM129A family with sequence similarity 129, member A
FN1 fibronectin 1
FTH1 ferritin, heavy polypeptide 1
FYN FYN proto-oncogene, Src family tyrosine kinase
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GDF15 growth differentiation factor 15
GULP1 GULP, engulfment adaptor PTB domain containing 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2AC histone cluster 1, H2ac
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFRD1 interferon-related developmental regulator 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
INHBE inhibin, beta E
IRS2 insulin receptor substrate 2
JMJD6 jumonji domain containing 6
KDM5A lysine (K)-specific demethylase 5A
KDM5D lysine (K)-specific demethylase 5D
KRT19 keratin 19, type I
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LITAF lipopolysaccharide-induced TNF factor
LY96 lymphocyte antigen 96
MARS methionyl-tRNA synthetase
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP7 matrix metallopeptidase 7
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MYLK myosin light chain kinase
NQO1 NAD(P)H dehydrogenase, quinone 1
NQO2 NAD(P)H dehydrogenase, quinone 2
OSER1 oxidative stress responsive serine-rich 1
PIEZO2 piezo-type mechanosensitive ion channel component 2
PIR pirin (iron-binding nuclear protein)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POPDC3 popeye domain containing 3
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
S100P S100 calcium binding protein P
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SFRP4 secreted frizzled-related protein 4
SH3BGR SH3 domain binding glutamate-rich protein
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC38A2 solute carrier family 38, member 2
SLC38A6 solute carrier family 38, member 6
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPON2 spondin 2, extracellular matrix protein
SQSTM1 sequestosome 1
SULF1 sulfatase 1
TARS threonyl-tRNA synthetase
TBPL1 TBP-like 1
TF transferrin
TGFA transforming growth factor, alpha
TGFBI transforming growth factor, beta-induced, 68kDa
TGIF1 TGFB-induced factor homeobox 1
THBS2 thrombospondin 2
TMEM47 transmembrane protein 47
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TPBG trophoblast glycoprotein
TPD52L1 tumor protein D52-like 1
TPM2 tropomyosin 2 (beta)
TTN titin
TXNRD1 thioredoxin reductase 1
VEGFA vascular endothelial growth factor A
WNT5A wingless-type MMTV integration site family, member 5A
YBX3 Y box binding protein 3
ZBTB10 zinc finger and BTB domain containing 10

decreased expression

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
APOD apolipoprotein D
AREG amphiregulin
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CCL19 chemokine (C-C motif) ligand 19
CCND3 cyclin D3
CCNF cyclin F
CORO1A coronin, actin binding protein, 1A
CPA3 carboxypeptidase A3 (mast cell)
CXCL14 chemokine (C-X-C motif) ligand 14
FSD1 fibronectin type III and SPRY domain containing 1
GATA2 GATA binding protein 2
GLDC glycine dehydrogenase (decarboxylating)
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KRT1 keratin 1, type II
LRRN3 leucine rich repeat neuronal 3
MLEC malectin
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PI3 peptidase inhibitor 3, skin-derived
PRKCB protein kinase C, beta
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAB2A RAB2A, member RAS oncogene family
RABAC1 Rab acceptor 1 (prenylated)
RBPMS RNA binding protein with multiple splicing
REEP1 receptor accessory protein 1
S100A7 S100 calcium binding protein A7
SCGB2A2 secretoglobin, family 2A, member 2
SLURP1 secreted LY6/PLAUR domain containing 1
SMC1A structural maintenance of chromosomes 1A
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SPRR2B small proline-rich protein 2B
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRIM29 tripartite motif containing 29
TUBB4B tubulin, beta 4B class IVb
TYRP1 tyrosinase-related protein 1
UBA1 ubiquitin-like modifier activating enzyme 1
VIM vimentin
XIST X inactive specific transcript (non-protein coding)