BRD-K07303502_Arachidonyl trifluoro-methyl ketone_MCF7_6.0_h_80.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

193 genes differentially expressed following the BRD-K07303502_Arachidonyl trifluoro-methyl ketone_MCF7_6.0_h_80.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANXA1 annexin A1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARID4B AT rich interactive domain 4B (RBP1-like)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
AXL AXL receptor tyrosine kinase
CARS cysteinyl-tRNA synthetase
CBR3 carbonyl reductase 3
CBS cystathionine-beta-synthase
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLU clusterin
CNOT4 CCR4-NOT transcription complex, subunit 4
COL11A1 collagen, type XI, alpha 1
COMP cartilage oligomeric matrix protein
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EREG epiregulin
FKBP14 FK506 binding protein 14, 22 kDa
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
FXR1 fragile X mental retardation, autosomal homolog 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
GCLM glutamate-cysteine ligase, modifier subunit
GLIPR1 GLI pathogenesis-related 1
GOSR1 golgi SNAP receptor complex member 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
H2BFS H2B histone family, member S (pseudogene)
HGD homogentisate 1,2-dioxygenase
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BK histone cluster 1, H2bk
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFRD1 interferon-related developmental regulator 1
IL1R2 interleukin 1 receptor, type II
ITCH itchy E3 ubiquitin protein ligase
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
KCTD5 potassium channel tetramerization domain containing 5
KLF4 Kruppel-like factor 4 (gut)
KLHDC10 kelch domain containing 10
KRT18 keratin 18, type I
KRT19 keratin 19, type I
LARP6 La ribonucleoprotein domain family, member 6
LOX lysyl oxidase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MARS methionyl-tRNA synthetase
MFAP5 microfibrillar associated protein 5
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MT1M metallothionein 1M
MUC5B mucin 5B, oligomeric mucus/gel-forming
NFIL3 nuclear factor, interleukin 3 regulated
NQO1 NAD(P)H dehydrogenase, quinone 1
ODC1 ornithine decarboxylase 1
OSER1 oxidative stress responsive serine-rich 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PEG3 paternally expressed 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIR pirin (iron-binding nuclear protein)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POPDC3 popeye domain containing 3
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRKCB protein kinase C, beta
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RSRC2 arginine/serine-rich coiled-coil 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMOX spermine oxidase
SQSTM1 sequestosome 1
SRGN serglycin
TARS threonyl-tRNA synthetase
TGFA transforming growth factor, alpha
TGFBI transforming growth factor, beta-induced, 68kDa
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRIM38 tripartite motif containing 38
TSC22D3 TSC22 domain family, member 3
TXNL4B thioredoxin-like 4B
TXNRD1 thioredoxin reductase 1
UBE3C ubiquitin protein ligase E3C
UBXN7 UBX domain protein 7
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
XPOT exportin, tRNA
ZBTB20 zinc finger and BTB domain containing 20
ZCCHC8 zinc finger, CCHC domain containing 8
ZFP36 ZFP36 ring finger protein
ZNF292 zinc finger protein 292

decreased expression

Symbol Name
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
AGTR1 angiotensin II receptor, type 1
APOD apolipoprotein D
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ATF5 activating transcription factor 5
B3GNT1
CA12 carbonic anhydrase XII
CAPN3 calpain 3, (p94)
CCNA2 cyclin A2
CCNE2 cyclin E2
CCNF cyclin F
CD58 CD58 molecule
CDC25A cell division cycle 25A
CHIT1 chitinase 1 (chitotriosidase)
CMC4 C-x(9)-C motif containing 4
CMTM6 CKLF-like MARVEL transmembrane domain containing 6
CPM carboxypeptidase M
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
EMP2 epithelial membrane protein 2
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAR2 fatty acyl CoA reductase 2
FDX1 ferredoxin 1
FEN1 flap structure-specific endonuclease 1
FOXA1 forkhead box A1
GATA3 GATA binding protein 3
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GSTM3 glutathione S-transferase mu 3 (brain)
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
H2AFX H2A histone family, member X
HMGN3 high mobility group nucleosomal binding domain 3
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
INPP5A inositol polyphosphate-5-phosphatase, 40kDa
LAMP5 lysosomal-associated membrane protein family, member 5
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LRRN3 leucine rich repeat neuronal 3
MARCKSL1 MARCKS-like 1
MLPH melanophilin
MREG melanoregulin
MYCBP MYC binding protein
NAV2 neuron navigator 2
NFIB nuclear factor I/B
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NREP neuronal regeneration related protein
PCNA proliferating cell nuclear antigen
PDLIM3 PDZ and LIM domain 3
PDZRN3 PDZ domain containing ring finger 3
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PRKCD protein kinase C, delta
PSRC1 proline/serine-rich coiled-coil 1
PTTG1 pituitary tumor-transforming 1
RFC3 replication factor C (activator 1) 3, 38kDa
RHOBTB3 Rho-related BTB domain containing 3
SGK1 serum/glucocorticoid regulated kinase 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
SPTBN1 spectrin, beta, non-erythrocytic 1
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TMEM164 transmembrane protein 164
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TYRP1 tyrosinase-related protein 1