BRD-K07303502_Arachidonyl trifluoro-methyl ketone_HEPG2_6.0_h_80.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

115 genes differentially expressed following the BRD-K07303502_Arachidonyl trifluoro-methyl ketone_HEPG2_6.0_h_80.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ARC activity-regulated cytoskeleton-associated protein
ATF3 activating transcription factor 3
AXL AXL receptor tyrosine kinase
BAG3 BCL2-associated athanogene 3
BGN biglycan
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
CCNL1 cyclin L1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CRABP1 cellular retinoic acid binding protein 1
CSNK1A1 casein kinase 1, alpha 1
CSRP2 cysteine and glycine-rich protein 2
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
FMOD fibromodulin
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOXO4 forkhead box O4
FZD7 frizzled class receptor 7
GADD45B growth arrest and DNA-damage-inducible, beta
H2BFS H2B histone family, member S (pseudogene)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AE histone cluster 1, H2ae
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER2 immediate early response 2
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KLK10 kallikrein-related peptidase 10
KLK5 kallikrein-related peptidase 5
LDLR low density lipoprotein receptor
LEF1 lymphoid enhancer-binding factor 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MEG3 maternally expressed 3 (non-protein coding)
MT1X metallothionein 1X
NET1 neuroepithelial cell transforming 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NT5E 5'-nucleotidase, ecto (CD73)
OSER1 oxidative stress responsive serine-rich 1
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PELI2 pellino E3 ubiquitin protein ligase family member 2
PLCB4 phospholipase C, beta 4
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRAME preferentially expressed antigen in melanoma
RAI2 retinoic acid induced 2
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
SCG2 secretogranin II
SCGB2A1 secretoglobin, family 2A, member 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
STAR steroidogenic acute regulatory protein
TMEM176B transmembrane protein 176B
TSC22D1 TSC22 domain family, member 1
TWIST1 twist family bHLH transcription factor 1
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ARMT1 acidic residue methyltransferase 1
ATF5 activating transcription factor 5
BUB3 BUB3 mitotic checkpoint protein
C6ORF62 chromosome 6 open reading frame 62
CAV2 caveolin 2
CDCA4 cell division cycle associated 4
COX11 COX11 cytochrome c oxidase copper chaperone
DHCR24 24-dehydrocholesterol reductase
GJA1 gap junction protein, alpha 1, 43kDa
IFITM1 interferon induced transmembrane protein 1
IRS1 insulin receptor substrate 1
JAG1 jagged 1
LBR lamin B receptor
MAGED1 melanoma antigen family D1
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MKL2 MKL/myocardin-like 2
NPY1R neuropeptide Y receptor Y1
POSTN periostin, osteoblast specific factor
PTP4A2 protein tyrosine phosphatase type IVA, member 2
QDPR quinoid dihydropteridine reductase
RBBP4 retinoblastoma binding protein 4
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STEAP1 six transmembrane epithelial antigen of the prostate 1
SUB1 SUB1 homolog (S. cerevisiae)
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM9SF2 transmembrane 9 superfamily member 2
USP22 ubiquitin specific peptidase 22