BRD-K07303502_Arachidonyl trifluoro-methyl ketone_HCC515_24.0_h_80.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

235 genes differentially expressed following the BRD-K07303502_Arachidonyl trifluoro-methyl ketone_HCC515_24.0_h_80.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALAS1 5'-aminolevulinate synthase 1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
AQP3 aquaporin 3 (Gill blood group)
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX3 armadillo repeat containing, X-linked 3
ARMCX6 armadillo repeat containing, X-linked 6
ASNS asparagine synthetase (glutamine-hydrolyzing)
CADM1 cell adhesion molecule 1
CCPG1 cell cycle progression 1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CLC Charcot-Leyden crystal galectin
CRYAB crystallin, alpha B
CTSL cathepsin L
CYB5R1 cytochrome b5 reductase 1
CYLD cylindromatosis (turban tumor syndrome)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM129A family with sequence similarity 129, member A
FOSL1 FOS-like antigen 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GULP1 GULP, engulfment adaptor PTB domain containing 1
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IFI27 interferon, alpha-inducible protein 27
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
JMJD1C jumonji domain containing 1C
KLHL24 kelch-like family member 24
LAMP2 lysosomal-associated membrane protein 2
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MIR22HG MIR22 host gene
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSRB1 methionine sulfoxide reductase B1
NEFL neurofilament, light polypeptide
NPC1 Niemann-Pick disease, type C1
NRBF2 nuclear receptor binding factor 2
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAP prosaposin
RAD9A RAD9 homolog A (S. pombe)
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RIOK3 RIO kinase 3
RIT1 Ras-like without CAAX 1
SEC24A SEC24 family member A
SECISBP2L SECIS binding protein 2-like
SH3BGR SH3 domain binding glutamate-rich protein
SLC31A2 solute carrier family 31 (copper transporter), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPP1 secreted phosphoprotein 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TPP1 tripeptidyl peptidase I
TUBB2B tubulin, beta 2B class IIb
TUFT1 tuftelin 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
ZFP36 ZFP36 ring finger protein
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AGR2 anterior gradient 2
AHCY adenosylhomocysteinase
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BZW2 basic leucine zipper and W2 domains 2
C3 complement component 3
C5 complement component 5
CALD1 caldesmon 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCDC85B coiled-coil domain containing 85B
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCNB1 cyclin B1
CCND1 cyclin D1
CCNF cyclin F
CD44 CD44 molecule (Indian blood group)
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CENPM centromere protein M
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
COL3A1 collagen, type III, alpha 1
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
CXCL9 chemokine (C-X-C motif) ligand 9
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUT deoxyuridine triphosphatase
E2F8 E2F transcription factor 8
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FANCI Fanconi anemia, complementation group I
FASN fatty acid synthase
FBL fibrillarin
FEN1 flap structure-specific endonuclease 1
FGA fibrinogen alpha chain
FGFR3 fibroblast growth factor receptor 3
FOXM1 forkhead box M1
GAS1 growth arrest-specific 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GPI glucose-6-phosphate isomerase
GTSE1 G-2 and S-phase expressed 1
H2AFZ H2A histone family, member Z
HADH hydroxyacyl-CoA dehydrogenase
HEG1 heart development protein with EGF-like domains 1
HJURP Holliday junction recognition protein
HMGB2 high mobility group box 2
ICMT isoprenylcysteine carboxyl methyltransferase
IGFBP3 insulin-like growth factor binding protein 3
IGFBP4 insulin-like growth factor binding protein 4
IGFBP7 insulin-like growth factor binding protein 7
IGL immunoglobulin lambda locus
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
ITGB3BP integrin beta 3 binding protein (beta3-endonexin)
ITM2A integral membrane protein 2A
KAZN kazrin, periplakin interacting protein
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF4A kinesin family member 4A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT7 keratin 7, type II
KRT8 keratin 8, type II
LIG1 ligase I, DNA, ATP-dependent
LIMCH1 LIM and calponin homology domains 1
LMNB1 lamin B1
LMNB2 lamin B2
LUM lumican
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MKI67 marker of proliferation Ki-67
MLPH melanophilin
MMD monocyte to macrophage differentiation-associated
MMP12 matrix metallopeptidase 12
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MUC1 mucin 1, cell surface associated
MUC16 mucin 16, cell surface associated
MXRA7 matrix-remodelling associated 7
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCBP MYC binding protein
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
NEK2 NIMA-related kinase 2
NME1 NME/NM23 nucleoside diphosphate kinase 1
NNMT nicotinamide N-methyltransferase
NR2F1 nuclear receptor subfamily 2, group F, member 1
NUP85 nucleoporin 85kDa
NUSAP1 nucleolar and spindle associated protein 1
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PCNA proliferating cell nuclear antigen
PDE4B phosphodiesterase 4B, cAMP-specific
PEBP1 phosphatidylethanolamine binding protein 1
PLK1 polo-like kinase 1
PON2 paraoxonase 2
PPIH peptidylprolyl isomerase H (cyclophilin H)
PRC1 protein regulator of cytokinesis 1
PRKCH protein kinase C, eta
PTGIS prostaglandin I2 (prostacyclin) synthase
PTTG1 pituitary tumor-transforming 1
PUS7 pseudouridylate synthase 7 (putative)
RACGAP1 Rac GTPase activating protein 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RBP1 retinol binding protein 1, cellular
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RPIA ribose 5-phosphate isomerase A
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
S100A4 S100 calcium binding protein A4
SAC3D1 SAC3 domain containing 1
SCARB1 scavenger receptor class B, member 1
SEPT11 septin 11
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A4RG SLC2A4 regulator
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SMC4 structural maintenance of chromosomes 4
SORD sorbitol dehydrogenase
SOX4 SRY (sex determining region Y)-box 4
SPC25 SPC25, NDC80 kinetochore complex component
SPDEF SAM pointed domain containing ETS transcription factor
SRSF7 serine/arginine-rich splicing factor 7
STMN1 stathmin 1
SUB1 SUB1 homolog (S. cerevisiae)
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
SULF1 sulfatase 1
TARBP1 TAR (HIV-1) RNA binding protein 1
TGM2 transglutaminase 2
TIMELESS timeless circadian clock
TK1 thymidine kinase 1, soluble
TMEM97 transmembrane protein 97
TNS3 tensin 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM1 tropomyosin 1 (alpha)
TPX2 TPX2, microtubule-associated
TRIB2 tribbles pseudokinase 2
TRIP13 thyroid hormone receptor interactor 13
TRMT5 tRNA methyltransferase 5
TSPAN12 tetraspanin 12
TSPAN8 tetraspanin 8
TUBB tubulin, beta class I
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
USP1 ubiquitin specific peptidase 1
VCAN versican
ZWINT ZW10 interacting kinetochore protein