BRD-K07303502_Arachidonyl trifluoro-methyl ketone_HCC15_6.0_h_80.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

73 genes differentially expressed following the BRD-K07303502_Arachidonyl trifluoro-methyl ketone_HCC15_6.0_h_80.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTG2 actin, gamma 2, smooth muscle, enteric
ANG angiogenin, ribonuclease, RNase A family, 5
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BEX1 brain expressed, X-linked 1
CD14 CD14 molecule
CD163 CD163 molecule
CLEC2B C-type lectin domain family 2, member B
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
ENOPH1 enolase-phosphatase 1
FAM69A family with sequence similarity 69, member A
FCGBP Fc fragment of IgG binding protein
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GJA1 gap junction protein, alpha 1, 43kDa
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IGFBP5 insulin-like growth factor binding protein 5
IRAK3 interleukin-1 receptor-associated kinase 3
KRT19 keratin 19, type I
KRT23 keratin 23, type I
MT1E metallothionein 1E
MYBPC1 myosin binding protein C, slow type
PDGFD platelet derived growth factor D
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PLIN2 perilipin 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRR15L proline rich 15-like
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RNASE4 ribonuclease, RNase A family, 4
RTN2 reticulon 2
SCN3A sodium channel, voltage gated, type III alpha subunit
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SOCS2 suppressor of cytokine signaling 2
SOX9 SRY (sex determining region Y)-box 9
THBS2 thrombospondin 2
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIB3 tribbles pseudokinase 3
TUBB2A tubulin, beta 2A class IIa

decreased expression

Symbol Name
AK1 adenylate kinase 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CD59 CD59 molecule, complement regulatory protein
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CPA3 carboxypeptidase A3 (mast cell)
CPSF1 cleavage and polyadenylation specific factor 1, 160kDa
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3
FOLR1 folate receptor 1 (adult)
FPGS folylpolyglutamate synthase
GATA2 GATA binding protein 2
GNAS GNAS complex locus
IFITM1 interferon induced transmembrane protein 1
IGFBP3 insulin-like growth factor binding protein 3
KANK2 KN motif and ankyrin repeat domains 2
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
LTF lactotransferrin
MAMLD1 mastermind-like domain containing 1
NPC2 Niemann-Pick disease, type C2
PEBP1 phosphatidylethanolamine binding protein 1
PODXL podocalyxin-like
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
PUF60 poly-U binding splicing factor 60KDa
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC39A4 solute carrier family 39 (zinc transporter), member 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)