BRD-K07303502_Arachidonyl trifluoro-methyl ketone_H1299_6.0_h_80.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

191 genes differentially expressed following the BRD-K07303502_Arachidonyl trifluoro-methyl ketone_H1299_6.0_h_80.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
ARID4B AT rich interactive domain 4B (RBP1-like)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BACE2 beta-site APP-cleaving enzyme 2
BAG3 BCL2-associated athanogene 3
BTG3 BTG family, member 3
C1ORF54 chromosome 1 open reading frame 54
C3ORF14 chromosome 3 open reading frame 14
CA2 carbonic anhydrase II
CCNL1 cyclin L1
CD24 CD24 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLC Charcot-Leyden crystal galectin
COL11A1 collagen, type XI, alpha 1
COL15A1 collagen, type XV, alpha 1
COL1A1 collagen, type I, alpha 1
COL2A1 collagen, type II, alpha 1
COL9A2 collagen, type IX, alpha 2
CSRP2 cysteine and glycine-rich protein 2
CXORF57 chromosome X open reading frame 57
DDIT3 DNA-damage-inducible transcript 3
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
FOXF2 forkhead box F2
FOXO4 forkhead box O4
FXR1 fragile X mental retardation, autosomal homolog 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GEM GTP binding protein overexpressed in skeletal muscle
GLA galactosidase, alpha
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBP1 HMG-box transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
HTRA1 HtrA serine peptidase 1
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IL6 interleukin 6
IPO13 importin 13
ISG20 interferon stimulated exonuclease gene 20kDa
JCHAIN joining chain of multimeric IgA and IgM
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KDM6A lysine (K)-specific demethylase 6A
KLK10 kallikrein-related peptidase 10
LCN2 lipocalin 2
LEF1 lymphoid enhancer-binding factor 1
LPPR4 lipid phosphate phosphatase-related protein type 4
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MGAM maltase-glucoamylase
MMP3 matrix metallopeptidase 3
MRPL18 mitochondrial ribosomal protein L18
MSX1 msh homeobox 1
MTUS1 microtubule associated tumor suppressor 1
NCF2 neutrophil cytosolic factor 2
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NOTCH3 notch 3
NQO1 NAD(P)H dehydrogenase, quinone 1
NXF1 nuclear RNA export factor 1
OSER1 oxidative stress responsive serine-rich 1
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PELI1 pellino E3 ubiquitin protein ligase 1
PLVAP plasmalemma vesicle associated protein
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PTN pleiotrophin
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
RGS5 regulator of G-protein signaling 5
RND3 Rho family GTPase 3
RYBP RING1 and YY1 binding protein
S100P S100 calcium binding protein P
SERINC5 serine incorporator 5
SFRP4 secreted frizzled-related protein 4
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNX7 sorting nexin 7
SPINK1 serine peptidase inhibitor, Kazal type 1
TBPL1 TBP-like 1
TBX2 T-box 2
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TCP1 t-complex 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TLK2 tousled-like kinase 2
TNPO1 transportin 1
TPD52 tumor protein D52
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
TWIST1 twist family bHLH transcription factor 1
TXNL4B thioredoxin-like 4B
TXNRD1 thioredoxin reductase 1
UFD1L ubiquitin fusion degradation 1 like (yeast)
VEGFA vascular endothelial growth factor A
WNT5A wingless-type MMTV integration site family, member 5A
WSB1 WD repeat and SOCS box containing 1
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACSF2 acyl-CoA synthetase family member 2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ANXA7 annexin A7
ATF5 activating transcription factor 5
AURKA aurora kinase A
BAD BCL2-associated agonist of cell death
BST2 bone marrow stromal cell antigen 2
C2CD2 C2 calcium-dependent domain containing 2
C7 complement component 7
CAPG capping protein (actin filament), gelsolin-like
CCDC85B coiled-coil domain containing 85B
CCNF cyclin F
CENPA centromere protein A
CHRDL1 chordin-like 1
CKB creatine kinase, brain
COG2 component of oligomeric golgi complex 2
CTSB cathepsin B
CTSC cathepsin C
CTSH cathepsin H
DCXR dicarbonyl/L-xylulose reductase
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
DPYSL3 dihydropyrimidinase-like 3
EHD1 EH-domain containing 1
EMP3 epithelial membrane protein 3
FAM57A family with sequence similarity 57, member A
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GRWD1 glutamate-rich WD repeat containing 1
HBB hemoglobin, beta
IGFBP4 insulin-like growth factor binding protein 4
IGFBP7 insulin-like growth factor binding protein 7
INPP5A inositol polyphosphate-5-phosphatase, 40kDa
KDM5D lysine (K)-specific demethylase 5D
KIF20A kinesin family member 20A
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MGLL monoglyceride lipase
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MXRA7 matrix-remodelling associated 7
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
NPY1R neuropeptide Y receptor Y1
PLA2G16 phospholipase A2, group XVI
PLAC8 placenta-specific 8
PLAT plasminogen activator, tissue
PLEKHJ1 pleckstrin homology domain containing, family J member 1
PLK1 polo-like kinase 1
PRKCA protein kinase C, alpha
PSCA prostate stem cell antigen
PTX3 pentraxin 3, long
PYGB phosphorylase, glycogen; brain
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RHOBTB3 Rho-related BTB domain containing 3
RPS4Y1 ribosomal protein S4, Y-linked 1
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SMAD3 SMAD family member 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SRPX sushi-repeat containing protein, X-linked
SRSF6 serine/arginine-rich splicing factor 6
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
ZNF131 zinc finger protein 131
ZNF22 zinc finger protein 22