BRD-K07303502_Arachidonyl trifluoro-methyl ketone_DV90_6.0_h_80.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

140 genes differentially expressed following the BRD-K07303502_Arachidonyl trifluoro-methyl ketone_DV90_6.0_h_80.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKAP12 A kinase (PRKA) anchor protein 12
AKAP13 A kinase (PRKA) anchor protein 13
ANXA1 annexin A1
ARC activity-regulated cytoskeleton-associated protein
ARL4C ADP-ribosylation factor-like 4C
ASPN asporin
ATF3 activating transcription factor 3
AUTS2 autism susceptibility candidate 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAG3 BCL2-associated athanogene 3
BPHL biphenyl hydrolase-like (serine hydrolase)
BTG1 B-cell translocation gene 1, anti-proliferative
C1ORF56 chromosome 1 open reading frame 56
CD200 CD200 molecule
CD52 CD52 molecule
CD93 CD93 molecule
CDO1 cysteine dioxygenase type 1
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
CNN3 calponin 3, acidic
COL5A2 collagen, type V, alpha 2
CTGF connective tissue growth factor
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL10 chemokine (C-X-C motif) ligand 10
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
EGR1 early growth response 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FABP1 fatty acid binding protein 1, liver
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FGL2 fibrinogen-like 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSL1 FOS-like antigen 1
FRY furry homolog (Drosophila)
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GATA3 GATA binding protein 3
GBP1 guanylate binding protein 1, interferon-inducible
H2BFS H2B histone family, member S (pseudogene)
HIST1H2AE histone cluster 1, H2ae
HIST1H2BG histone cluster 1, H2bg
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IER2 immediate early response 2
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFRD1 interferon-related developmental regulator 1
ISG15 ISG15 ubiquitin-like modifier
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KRAS Kirsten rat sarcoma viral oncogene homolog
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAOB monoamine oxidase B
MEF2C myocyte enhancer factor 2C
NRIP1 nuclear receptor interacting protein 1
PLK2 polo-like kinase 2
PODXL podocalyxin-like
POSTN periostin, osteoblast specific factor
PPAP2A phosphatidic acid phosphatase type 2A
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTN pleiotrophin
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RYBP RING1 and YY1 binding protein
SCGB2A1 secretoglobin, family 2A, member 1
SCRG1 stimulator of chondrogenesis 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SERTAD2 SERTA domain containing 2
SFN stratifin
SNAI2 snail family zinc finger 2
SPARCL1 SPARC-like 1 (hevin)
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STK38L serine/threonine kinase 38 like
SULF1 sulfatase 1
TAGLN transgelin
TBX3 T-box 3
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TCTA T-cell leukemia translocation altered
THBS1 thrombospondin 1
TMEM47 transmembrane protein 47
TMSB15A thymosin beta 15a
TOX3 TOX high mobility group box family member 3
TRIM36 tripartite motif containing 36
TUBB2A tubulin, beta 2A class IIa
WARS tryptophanyl-tRNA synthetase
WSB1 WD repeat and SOCS box containing 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AMPD3 adenosine monophosphate deaminase 3
B3GNT1
BICC1 BicC family RNA binding protein 1
BLVRA biliverdin reductase A
CA12 carbonic anhydrase XII
CCL20 chemokine (C-C motif) ligand 20
CCND2 cyclin D2
CPD carboxypeptidase D
CSK c-src tyrosine kinase
CTSH cathepsin H
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL5 chemokine (C-X-C motif) ligand 5
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EMP3 epithelial membrane protein 3
FKBP10 FK506 binding protein 10, 65 kDa
HEATR1 HEAT repeat containing 1
IPO13 importin 13
KIF2C kinesin family member 2C
LCN2 lipocalin 2
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LTF lactotransferrin
NUP62 nucleoporin 62kDa
NUP88 nucleoporin 88kDa
PDGFC platelet derived growth factor C
PSD3 pleckstrin and Sec7 domain containing 3
S100A8 S100 calcium binding protein A8
SACS sacsin molecular chaperone
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFRC transferrin receptor
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TXNIP thioredoxin interacting protein