BRD-K07303502_Arachidonyl trifluoro-methyl ketone_A375_24.0_h_80.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

352 genes differentially expressed following the BRD-K07303502_Arachidonyl trifluoro-methyl ketone_A375_24.0_h_80.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTG2 actin, gamma 2, smooth muscle, enteric
ADIRF adipogenesis regulatory factor
ADM adrenomedullin
AMIGO2 adhesion molecule with Ig-like domain 2
AQP1 aquaporin 1 (Colton blood group)
ARID5B AT rich interactive domain 5B (MRF1-like)
ARL4C ADP-ribosylation factor-like 4C
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAG3 BCL2-associated athanogene 3
BLNK B-cell linker
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
C1ORF56 chromosome 1 open reading frame 56
C1QA complement component 1, q subcomponent, A chain
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CCL8 chemokine (C-C motif) ligand 8
CCNA1 cyclin A1
CD200 CD200 molecule
CD24 CD24 molecule
CD69 CD69 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLC Charcot-Leyden crystal galectin
CLU clusterin
CPA3 carboxypeptidase A3 (mast cell)
CPE carboxypeptidase E
CRABP1 cellular retinoic acid binding protein 1
CRABP2 cellular retinoic acid binding protein 2
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR4 chemokine (C-X-C motif) receptor 4
CYR61 cysteine-rich, angiogenic inducer, 61
DENND1B DENN/MADD domain containing 1B
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DOK5 docking protein 5
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EDN1 endothelin 1
EFHD1 EF-hand domain family, member D1
EGLN3 egl-9 family hypoxia-inducible factor 3
EGR1 early growth response 1
EPAS1 endothelial PAS domain protein 1
EZR ezrin
FAM69A family with sequence similarity 69, member A
FGL2 fibrinogen-like 2
FILIP1L filamin A interacting protein 1-like
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FRY furry homolog (Drosophila)
FRZB frizzled-related protein
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
FXYD6 FXYD domain containing ion transport regulator 6
GAREM GRB2 associated, regulator of MAPK1
GATA2 GATA binding protein 2
GEM GTP binding protein overexpressed in skeletal muscle
GJA1 gap junction protein, alpha 1, 43kDa
GRB7 growth factor receptor-bound protein 7
H2BFS H2B histone family, member S (pseudogene)
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HILPDA hypoxia inducible lipid droplet-associated
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AE histone cluster 1, H2ae
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BI histone cluster 1, H2bi
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDO1 indoleamine 2,3-dioxygenase 1
IER2 immediate early response 2
IER5 immediate early response 5
IFI6 interferon, alpha-inducible protein 6
IFRD1 interferon-related developmental regulator 1
IGFBP5 insulin-like growth factor binding protein 5
IGL immunoglobulin lambda locus
IRF1 interferon regulatory factor 1
ISG15 ISG15 ubiquitin-like modifier
ITM2A integral membrane protein 2A
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIAA0226L KIAA0226-like
KLF11 Kruppel-like factor 11
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KRT23 keratin 23, type I
KRT8 keratin 8, type II
LDB2 LIM domain binding 2
LGMN legumain
LIMCH1 LIM and calponin homology domains 1
LOC100505650 uncharacterized LOC100505650
LPAR6 lysophosphatidic acid receptor 6
LRMP lymphoid-restricted membrane protein
LRP12 low density lipoprotein receptor-related protein 12
LYN LYN proto-oncogene, Src family tyrosine kinase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCL1 myeloid cell leukemia 1
MEIS2 Meis homeobox 2
MMP1 matrix metallopeptidase 1
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MT1F metallothionein 1F
MT1M metallothionein 1M
MTSS1 metastasis suppressor 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
ODC1 ornithine decarboxylase 1
ORM1 orosomucoid 1
PADI2 peptidyl arginine deiminase, type II
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PAWR PRKC, apoptosis, WT1, regulator
PCDH17 protocadherin 17
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PELI1 pellino E3 ubiquitin protein ligase 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLAGL1 pleiomorphic adenoma gene-like 1
PLAU plasminogen activator, urokinase
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PLVAP plasmalemma vesicle associated protein
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNP purine nucleoside phosphorylase
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
PTPRC protein tyrosine phosphatase, receptor type, C
PTPRO protein tyrosine phosphatase, receptor type, O
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RGS13 regulator of G-protein signaling 13
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RNF38 ring finger protein 38
RSAD2 radical S-adenosyl methionine domain containing 2
RTN2 reticulon 2
S100P S100 calcium binding protein P
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SIK1 salt-inducible kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SOX4 SRY (sex determining region Y)-box 4
SPARCL1 SPARC-like 1 (hevin)
SPP1 secreted phosphoprotein 1
SQLE squalene epoxidase
SST somatostatin
ST18 suppression of tumorigenicity 18, zinc finger
STC1 stanniocalcin 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
TCF4 transcription factor 4
TESK1 testis-specific kinase 1
TFPI2 tissue factor pathway inhibitor 2
TGIF1 TGFB-induced factor homeobox 1
THBD thrombomodulin
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOB1 transducer of ERBB2, 1
TOX thymocyte selection-associated high mobility group box
TPBG trophoblast glycoprotein
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRIB1 tribbles pseudokinase 1
TRIM36 tripartite motif containing 36
TSPAN13 tetraspanin 13
TUFT1 tuftelin 1
TXNL4B thioredoxin-like 4B
TYROBP TYRO protein tyrosine kinase binding protein
UGDH UDP-glucose 6-dehydrogenase
VEGFA vascular endothelial growth factor A
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)
ZBTB10 zinc finger and BTB domain containing 10
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1
ZFPM2 zinc finger protein, FOG family member 2
ZNF331 zinc finger protein 331
ZNF423 zinc finger protein 423

decreased expression

Symbol Name
AARS alanyl-tRNA synthetase
ACSL1 acyl-CoA synthetase long-chain family member 1
ACTN1 actinin, alpha 1
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ANXA7 annexin A7
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
B3GNT1
BLVRA biliverdin reductase A
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BST2 bone marrow stromal cell antigen 2
C5ORF15 chromosome 5 open reading frame 15
CCDC85B coiled-coil domain containing 85B
CCNG1 cyclin G1
CD151 CD151 molecule (Raph blood group)
CD59 CD59 molecule, complement regulatory protein
CDK1 cyclin-dependent kinase 1
CENPF centromere protein F, 350/400kDa
CHPT1 choline phosphotransferase 1
CMTM6 CKLF-like MARVEL transmembrane domain containing 6
CNPY2 canopy FGF signaling regulator 2
COA3 cytochrome c oxidase assembly factor 3
COASY CoA synthase
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CST3 cystatin C
CTSB cathepsin B
CTTN cortactin
CXCL14 chemokine (C-X-C motif) ligand 14
CYFIP2 cytoplasmic FMR1 interacting protein 2
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DCXR dicarbonyl/L-xylulose reductase
DFNA5 deafness, autosomal dominant 5
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
ECI2 enoyl-CoA delta isomerase 2
EMP3 epithelial membrane protein 3
ERBB3 erb-b2 receptor tyrosine kinase 3
EXOSC4 exosome component 4
FKBP10 FK506 binding protein 10, 65 kDa
G6PC3 glucose 6 phosphatase, catalytic, 3
GAA glucosidase, alpha; acid
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GAS7 growth arrest-specific 7
GLRX5 glutaredoxin 5
GOLGA8A golgin A8 family, member A
GPX1 glutathione peroxidase 1
GSTP1 glutathione S-transferase pi 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HOXC6 homeobox C6
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4
ICMT isoprenylcysteine carboxyl methyltransferase
IL6ST interleukin 6 signal transducer
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
ITPK1 inositol-tetrakisphosphate 1-kinase
KAZN kazrin, periplakin interacting protein
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KDM4B lysine (K)-specific demethylase 4B
KIF1B kinesin family member 1B
KIF20A kinesin family member 20A
LAMC1 laminin, gamma 1 (formerly LAMB2)
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIPA lipase A, lysosomal acid, cholesterol esterase
LY6D lymphocyte antigen 6 complex, locus D
MAGED1 melanoma antigen family D1
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MSRB2 methionine sulfoxide reductase B2
MYH10 myosin, heavy chain 10, non-muscle
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NCOR2 nuclear receptor corepressor 2
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NISCH nischarin
NME4 NME/NM23 nucleoside diphosphate kinase 4
NNT nicotinamide nucleotide transhydrogenase
NOTCH2 notch 2
NPC2 Niemann-Pick disease, type C2
NPY neuropeptide Y
NRIP1 nuclear receptor interacting protein 1
NUP210 nucleoporin 210kDa
OSBPL8 oxysterol binding protein-like 8
PCBP4 poly(rC) binding protein 4
PCYOX1L prenylcysteine oxidase 1 like
PDLIM2 PDZ and LIM domain 2 (mystique)
PDLIM4 PDZ and LIM domain 4
PDS5A PDS5 cohesin associated factor A
PGM1 phosphoglucomutase 1
PI3 peptidase inhibitor 3, skin-derived
PRDX3 peroxiredoxin 3
PRKCA protein kinase C, alpha
PRKCD protein kinase C, delta
PRR7 proline rich 7 (synaptic)
PTGES prostaglandin E synthase
PURA purine-rich element binding protein A
QDPR quinoid dihydropteridine reductase
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RPS11 ribosomal protein S11
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SACM1L SAC1 suppressor of actin mutations 1-like (yeast)
SACS sacsin molecular chaperone
SCP2 sterol carrier protein 2
SEC23A Sec23 homolog A (S. cerevisiae)
SEPHS1 selenophosphate synthetase 1
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SET SET nuclear proto-oncogene
SIAH2 siah E3 ubiquitin protein ligase 2
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMAD3 SMAD family member 3
SORD sorbitol dehydrogenase
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRPX sushi-repeat containing protein, X-linked
STOM stomatin
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SVIL supervillin
TBC1D16 TBC1 domain family, member 16
TBL1X transducin (beta)-like 1X-linked
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TMBIM6 transmembrane BAX inhibitor motif containing 6
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TMF1 TATA element modulatory factor 1
TMX4 thioredoxin-related transmembrane protein 4
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TSPAN3 tetraspanin 3
UBE2E1 ubiquitin-conjugating enzyme E2E 1
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X
WDR61 WD repeat domain 61
WFDC2 WAP four-disulfide core domain 2
ZCCHC24 zinc finger, CCHC domain containing 24