BRD-K07259155_NCGC00182362-01_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

166 genes differentially expressed following the BRD-K07259155_NCGC00182362-01_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANKRD10 ankyrin repeat domain 10
ARHGAP12 Rho GTPase activating protein 12
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAMBI BMP and activin membrane-bound inhibitor
BLVRB biliverdin reductase B
C6ORF62 chromosome 6 open reading frame 62
CA2 carbonic anhydrase II
CARS cysteinyl-tRNA synthetase
CBR1 carbonyl reductase 1
CBR3 carbonyl reductase 3
CCNG2 cyclin G2
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLCN3 chloride channel, voltage-sensitive 3
CLIC4 chloride intracellular channel 4
COMP cartilage oligomeric matrix protein
CTSL cathepsin L
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCLK1 doublecortin-like kinase 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DSP desmoplakin
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FOXO4 forkhead box O4
FTH1 ferritin, heavy polypeptide 1
G6PD glucose-6-phosphate dehydrogenase
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GPX2 glutathione peroxidase 2
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
ITGB5 integrin, beta 5
KCTD9 potassium channel tetramerization domain containing 9
KRAS Kirsten rat sarcoma viral oncogene homolog
KYNU kynureninase
LRP10 low density lipoprotein receptor-related protein 10
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1A1 mannosidase, alpha, class 1A, member 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MIR22HG MIR22 host gene
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYO10 myosin X
NQO1 NAD(P)H dehydrogenase, quinone 1
NUPR1 nuclear protein, transcriptional regulator, 1
P2RY14 purinergic receptor P2Y, G-protein coupled, 14
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PFN2 profilin 2
PIR pirin (iron-binding nuclear protein)
PPAP2B phosphatidic acid phosphatase type 2B
PRDX1 peroxiredoxin 1
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RIOK3 RIO kinase 3
RIT1 Ras-like without CAAX 1
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SQSTM1 sequestosome 1
STC2 stanniocalcin 2
SWAP70 SWAP switching B-cell complex 70kDa subunit
TALDO1 transaldolase 1
TGIF1 TGFB-induced factor homeobox 1
TMEM2 transmembrane protein 2
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TSKU tsukushi, small leucine rich proteoglycan
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGDH UDP-glucose 6-dehydrogenase
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
VGLL4 vestigial-like family member 4
WSB1 WD repeat and SOCS box containing 1

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ACOT7 acyl-CoA thioesterase 7
ANXA6 annexin A6
ATP5I ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E
B3GNT1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
C1QBP complement component 1, q subcomponent binding protein
CCDC85B coiled-coil domain containing 85B
CD320 CD320 molecule
CDC25A cell division cycle 25A
CFB complement factor B
CLC Charcot-Leyden crystal galectin
COL13A1 collagen, type XIII, alpha 1
COL1A2 collagen, type I, alpha 2
COL6A1 collagen, type VI, alpha 1
CTPS1 CTP synthase 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DES desmin
DHCR24 24-dehydrocholesterol reductase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ELOVL6 ELOVL fatty acid elongase 6
FABP6 fatty acid binding protein 6, ileal
FASN fatty acid synthase
FEN1 flap structure-specific endonuclease 1
FJX1 four jointed box 1 (Drosophila)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HELLS helicase, lymphoid-specific
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
ICMT isoprenylcysteine carboxyl methyltransferase
IFITM1 interferon induced transmembrane protein 1
IFITM3 interferon induced transmembrane protein 3
IL7R interleukin 7 receptor
INSIG1 insulin induced gene 1
KCTD12 potassium channel tetramerization domain containing 12
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIG1 ligase I, DNA, ATP-dependent
MAGEA3 melanoma antigen family A3
MCAM melanoma cell adhesion molecule
MCM2 minichromosome maintenance complex component 2
MCM4 minichromosome maintenance complex component 4
MRPL20 mitochondrial ribosomal protein L20
MXRA5 matrix-remodelling associated 5
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
NREP neuronal regeneration related protein
PCNA proliferating cell nuclear antigen
PGM1 phosphoglucomutase 1
PLAT plasminogen activator, tissue
PNP purine nucleoside phosphorylase
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PRDX2 peroxiredoxin 2
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SCARB1 scavenger receptor class B, member 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SRGN serglycin
SRM spermidine synthase
ST7 suppression of tumorigenicity 7
SUSD4 sushi domain containing 4
TRIP13 thyroid hormone receptor interactor 13
TUSC3 tumor suppressor candidate 3
WWC1 WW and C2 domain containing 1