BRD-K07079548_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

75 genes differentially expressed following the BRD-K07079548_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGTR1 angiotensin II receptor, type 1
AMIGO2 adhesion molecule with Ig-like domain 2
APOD apolipoprotein D
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
BST2 bone marrow stromal cell antigen 2
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL8 chemokine (C-C motif) ligand 8
CEP57 centrosomal protein 57kDa
CLIC4 chloride intracellular channel 4
COL10A1 collagen, type X, alpha 1
CRISP3 cysteine-rich secretory protein 3
DDIT4 DNA-damage-inducible transcript 4
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IGHM immunoglobulin heavy constant mu
IKZF1 IKAROS family zinc finger 1 (Ikaros)
KRT6B keratin 6B, type II
LPIN1 lipin 1
MAP7 microtubule-associated protein 7
MCOLN1 mucolipin 1
MFAP5 microfibrillar associated protein 5
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
NTS neurotensin
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PDE4DIP phosphodiesterase 4D interacting protein
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RRAGD Ras-related GTP binding D
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin
SLAMF7 SLAM family member 7
SLC16A6 solute carrier family 16, member 6
SNAI2 snail family zinc finger 2
SORBS2 sorbin and SH3 domain containing 2
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
TM4SF1 transmembrane 4 L six family member 1
TPD52 tumor protein D52
XAF1 XIAP associated factor 1

decreased expression

Symbol Name
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ASS1 argininosuccinate synthase 1
BEX1 brain expressed, X-linked 1
C1QL1 complement component 1, q subcomponent-like 1
CA2 carbonic anhydrase II
COL3A1 collagen, type III, alpha 1
CSRP2 cysteine and glycine-rich protein 2
CX3CR1 chemokine (C-X3-C motif) receptor 1
FABP1 fatty acid binding protein 1, liver
FCGBP Fc fragment of IgG binding protein
GJA1 gap junction protein, alpha 1, 43kDa
GPX3 glutathione peroxidase 3
HAL histidine ammonia-lyase
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
ITM2C integral membrane protein 2C
KCTD12 potassium channel tetramerization domain containing 12
KRT13 keratin 13, type I
LTBP1 latent transforming growth factor beta binding protein 1
MATN2 matrilin 2
MECOM MDS1 and EVI1 complex locus
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NREP neuronal regeneration related protein
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PMP2 peripheral myelin protein 2
RGS1 regulator of G-protein signaling 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SOX4 SRY (sex determining region Y)-box 4
SYBU syntabulin (syntaxin-interacting)
TACC2 transforming, acidic coiled-coil containing protein 2
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNC1 troponin C type 1 (slow)
TNNT1 troponin T type 1 (skeletal, slow)
WWTR1 WW domain containing transcription regulator 1