BRD-K07023879_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

82 genes differentially expressed following the BRD-K07023879_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGR2 anterior gradient 2
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
BZW2 basic leucine zipper and W2 domains 2
C6ORF48 chromosome 6 open reading frame 48
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COMP cartilage oligomeric matrix protein
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
ERP29 endoplasmic reticulum protein 29
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
GPRC5A G protein-coupled receptor, class C, group 5, member A
IFRD1 interferon-related developmental regulator 1
IL1R2 interleukin 1 receptor, type II
IL6ST interleukin 6 signal transducer
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KRT18 keratin 18, type I
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NEBL nebulette
NFIL3 nuclear factor, interleukin 3 regulated
NOTCH2 notch 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PER1 period circadian clock 1
PHGDH phosphoglycerate dehydrogenase
PSAT1 phosphoserine aminotransferase 1
RAP1GAP RAP1 GTPase activating protein
RHOB ras homolog family member B
S100A7 S100 calcium binding protein A7
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SIK1 salt-inducible kinase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC38A1 solute carrier family 38, member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TFF1 trefoil factor 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNC tenascin C
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TSC22D3 TSC22 domain family, member 3
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
ZFAND5 zinc finger, AN1-type domain 5

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ATF5 activating transcription factor 5
BPTF bromodomain PHD finger transcription factor
CCL5 chemokine (C-C motif) ligand 5
CD44 CD44 molecule (Indian blood group)
CKB creatine kinase, brain
COL4A5 collagen, type IV, alpha 5
COL4A6 collagen, type IV, alpha 6
CSTA cystatin A (stefin A)
FABP4 fatty acid binding protein 4, adipocyte
FAIM Fas apoptotic inhibitory molecule
GJA1 gap junction protein, alpha 1, 43kDa
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
MXRA7 matrix-remodelling associated 7
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PRTN3 proteinase 3
PTHLH parathyroid hormone-like hormone
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPS4Y1 ribosomal protein S4, Y-linked 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
TGFBR3 transforming growth factor, beta receptor III
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
WBP5 WW domain binding protein 5
XCL1 chemokine (C motif) ligand 1