BRD-K07005393_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

87 genes differentially expressed following the BRD-K07005393_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
AGR2 anterior gradient 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ASNS asparagine synthetase (glutamine-hydrolyzing)
BLNK B-cell linker
C10ORF10 chromosome 10 open reading frame 10
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEP57 centrosomal protein 57kDa
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CNN3 calponin 3, acidic
CRIP1 cysteine-rich protein 1 (intestinal)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CX3CL1 chemokine (C-X3-C motif) ligand 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
ECM1 extracellular matrix protein 1
FBLN1 fibulin 1
FKBP14 FK506 binding protein 14, 22 kDa
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HMOX1 heme oxygenase 1
HSPA4L heat shock 70kDa protein 4-like
IER3 immediate early response 3
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KRT18 keratin 18, type I
LCN2 lipocalin 2
LMO3 LIM domain only 3 (rhombotin-like 2)
MGP matrix Gla protein
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM4 olfactomedin 4
PLA2G16 phospholipase A2, group XVI
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SCGB1D2 secretoglobin, family 1D, member 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEC31A SEC31 homolog A (S. cerevisiae)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP4 secreted frizzled-related protein 4
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SOX9 SRY (sex determining region Y)-box 9
STOM stomatin
TFPI2 tissue factor pathway inhibitor 2
TMED2 transmembrane emp24 domain trafficking protein 2
TMEM45A transmembrane protein 45A
TRIM2 tripartite motif containing 2
VAMP8 vesicle-associated membrane protein 8
VIM vimentin
VSIG4 V-set and immunoglobulin domain containing 4

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ALCAM activated leukocyte cell adhesion molecule
ANPEP alanyl (membrane) aminopeptidase
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
CD36 CD36 molecule (thrombospondin receptor)
CD9 CD9 molecule
CDCA4 cell division cycle associated 4
CREB1 cAMP responsive element binding protein 1
DCK deoxycytidine kinase
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM46A family with sequence similarity 46, member A
H2AFX H2A histone family, member X
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
KANK1 KN motif and ankyrin repeat domains 1
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KNG1 kininogen 1
KRT14 keratin 14, type I
KRT17 keratin 17, type I
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)
PHACTR2 phosphatase and actin regulator 2
PRKD3 protein kinase D3
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
TACSTD2 tumor-associated calcium signal transducer 2
ZCCHC2 zinc finger, CCHC domain containing 2