BRD-K06854232_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

118 genes differentially expressed following the BRD-K06854232_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL3 acyl-CoA synthetase long-chain family member 3
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AQP3 aquaporin 3 (Gill blood group)
ARHGAP29 Rho GTPase activating protein 29
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BACE2 beta-site APP-cleaving enzyme 2
BHLHE41 basic helix-loop-helix family, member e41
C7 complement component 7
C8ORF4 chromosome 8 open reading frame 4
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CD36 CD36 molecule (thrombospondin receptor)
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
CPB1 carboxypeptidase B1 (tissue)
CPD carboxypeptidase D
CRABP1 cellular retinoic acid binding protein 1
CRABP2 cellular retinoic acid binding protein 2
CTSC cathepsin C
CXCL14 chemokine (C-X-C motif) ligand 14
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DACH1 dachshund family transcription factor 1
DCLK1 doublecortin-like kinase 1
DDIT4 DNA-damage-inducible transcript 4
DHRS3 dehydrogenase/reductase (SDR family) member 3
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP4 dual specificity phosphatase 4
EFNA1 ephrin-A1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
FABP4 fatty acid binding protein 4, adipocyte
FN1 fibronectin 1
FOXO3 forkhead box O3
FZD7 frizzled class receptor 7
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GRB7 growth factor receptor-bound protein 7
GSTP1 glutathione S-transferase pi 1
HES1 hes family bHLH transcription factor 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HOXA4 homeobox A4
HOXA5 homeobox A5
HOXA7 homeobox A7
HOXB2 homeobox B2
HOXB6 homeobox B6
HOXB7 homeobox B7
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IGFBP3 insulin-like growth factor binding protein 3
IGL immunoglobulin lambda locus
ITGB6 integrin, beta 6
KAZN kazrin, periplakin interacting protein
KLHDC2 kelch domain containing 2
KRT19 keratin 19, type I
KRT7 keratin 7, type II
KYNU kynureninase
LGALS3 lectin, galactoside-binding, soluble, 3
LIMCH1 LIM and calponin homology domains 1
LPL lipoprotein lipase
LXN latexin
MDK midkine (neurite growth-promoting factor 2)
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NQO1 NAD(P)H dehydrogenase, quinone 1
NRIP1 nuclear receptor interacting protein 1
OAT ornithine aminotransferase
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PRKCD protein kinase C, delta
PTX3 pentraxin 3, long
RAP1GAP RAP1 GTPase activating protein
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS2 regulator of G-protein signaling 2
RND3 Rho family GTPase 3
RNF167 ring finger protein 167
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
SDC4 syndecan 4
SEPT6 septin 6
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SKAP2 src kinase associated phosphoprotein 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SMAD3 SMAD family member 3
SOX9 SRY (sex determining region Y)-box 9
TCEA2 transcription elongation factor A (SII), 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TM4SF1 transmembrane 4 L six family member 1
TMEM100 transmembrane protein 100
TSC22D3 TSC22 domain family, member 3
VCAN versican
ZFPM2 zinc finger protein, FOG family member 2

decreased expression

Symbol Name
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CLCA1 chloride channel accessory 1
COL4A2 collagen, type IV, alpha 2
CTSZ cathepsin Z
DPYSL2 dihydropyrimidinase-like 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ESR1 estrogen receptor 1
GAB2 GRB2-associated binding protein 2
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GREB1 growth regulation by estrogen in breast cancer 1
H2AFV H2A histone family, member V
KRT23 keratin 23, type I
MAPT microtubule-associated protein tau
MATN2 matrilin 2
MME membrane metallo-endopeptidase
NCAPD3 non-SMC condensin II complex, subunit D3
PNMA1 paraneoplastic Ma antigen 1
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PSIP1 PC4 and SFRS1 interacting protein 1
PXDN peroxidasin
S100A7 S100 calcium binding protein A7
SDC2 syndecan 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SPON2 spondin 2, extracellular matrix protein
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17