BRD-K06792661_Narciclasine_SKMEL1_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

203 genes differentially expressed following the BRD-K06792661_Narciclasine_SKMEL1_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AREG amphiregulin
ARFIP2 ADP-ribosylation factor interacting protein 2
ARID1A AT rich interactive domain 1A (SWI-like)
ATF1 activating transcription factor 1
ATF3 activating transcription factor 3
BRD2 bromodomain containing 2
BTG2 BTG family, member 2
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CCNL1 cyclin L1
CD44 CD44 molecule (Indian blood group)
CEMIP cell migration inducing protein, hyaluronan binding
CHIC2 cysteine-rich hydrophobic domain 2
COL5A2 collagen, type V, alpha 2
CTSH cathepsin H
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EGR3 early growth response 3
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FLRT3 fibronectin leucine rich transmembrane protein 3
FNDC3B fibronectin type III domain containing 3B
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOXO3 forkhead box O3
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GATA3 GATA binding protein 3
GEM GTP binding protein overexpressed in skeletal muscle
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
H2BFS H2B histone family, member S (pseudogene)
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
ICAM1 intercellular adhesion molecule 1
IER2 immediate early response 2
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
IL6 interleukin 6
IRF7 interferon regulatory factor 7
ISG15 ISG15 ubiquitin-like modifier
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KDM6A lysine (K)-specific demethylase 6A
KLF6 Kruppel-like factor 6
KRT23 keratin 23, type I
LDLR low density lipoprotein receptor
LIPG lipase, endothelial
LRRC17 leucine rich repeat containing 17
MCL1 myeloid cell leukemia 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUPL1 nucleoporin like 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PER1 period circadian clock 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRPF3 pre-mRNA processing factor 3
PRUNE prune exopolyphosphatase
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RHOB ras homolog family member B
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RYBP RING1 and YY1 binding protein
SCYL3 SCY1-like 3 (S. cerevisiae)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SNX11 sorting nexin 11
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SP100 SP100 nuclear antigen
SQSTM1 sequestosome 1
SREK1 splicing regulatory glutamine/lysine-rich protein 1
SRRM2 serine/arginine repetitive matrix 2
STAT1 signal transducer and activator of transcription 1, 91kDa
STK17B serine/threonine kinase 17b
SUB1 SUB1 homolog (S. cerevisiae)
TBX2 T-box 2
TDO2 tryptophan 2,3-dioxygenase
TESC tescalcin
THBS1 thrombospondin 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TSC22D2 TSC22 domain family, member 2
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)
ZC3H12A zinc finger CCCH-type containing 12A
ZC3H15 zinc finger CCCH-type containing 15
ZFP36 ZFP36 ring finger protein
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ACOT7 acyl-CoA thioesterase 7
ACTA1 actin, alpha 1, skeletal muscle
ADGRG2 adhesion G protein-coupled receptor G2
ADIRF adipogenesis regulatory factor
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ANPEP alanyl (membrane) aminopeptidase
ANXA4 annexin A4
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
B3GNT1
BASP1 brain abundant, membrane attached signal protein 1
C6ORF62 chromosome 6 open reading frame 62
CAST calpastatin
CBR3 carbonyl reductase 3
CCDC86 coiled-coil domain containing 86
CD59 CD59 molecule, complement regulatory protein
CERK ceramide kinase
CKAP4 cytoskeleton-associated protein 4
CKLF chemokine-like factor
CLEC3B C-type lectin domain family 3, member B
CLGN calmegin
COL6A1 collagen, type VI, alpha 1
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver)
CREBL2 cAMP responsive element binding protein-like 2
CSTA cystatin A (stefin A)
CTSB cathepsin B
CYB5R3 cytochrome b5 reductase 3
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEGS1 delta(4)-desaturase, sphingolipid 1
DES desmin
DPYSL2 dihydropyrimidinase-like 2
DPYSL3 dihydropyrimidinase-like 3
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EPN2 epsin 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FBLN1 fibulin 1
FHL1 four and a half LIM domains 1
FOLR1 folate receptor 1 (adult)
GLRX glutaredoxin (thioltransferase)
HMGB3 high mobility group box 3
IDO1 indoleamine 2,3-dioxygenase 1
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KIAA0930 KIAA0930
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAP7 microtubule-associated protein 7
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MPRIP myosin phosphatase Rho interacting protein
MSLN mesothelin
MT1M metallothionein 1M
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MXRA7 matrix-remodelling associated 7
NBL1 neuroblastoma 1, DAN family BMP antagonist
NDN necdin, melanoma antigen (MAGE) family member
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NNMT nicotinamide N-methyltransferase
NPY1R neuropeptide Y receptor Y1
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PEBP1 phosphatidylethanolamine binding protein 1
PNMA1 paraneoplastic Ma antigen 1
PODXL podocalyxin-like
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRDX4 peroxiredoxin 4
PRKCB protein kinase C, beta
PXDN peroxidasin
RABAC1 Rab acceptor 1 (prenylated)
RPL27A ribosomal protein L27a
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
SAMM50 SAMM50 sorting and assembly machinery component
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEPP1 selenoprotein P, plasma, 1
SEPT11 septin 11
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SLAMF7 SLAM family member 7
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SNN stannin
SORBS3 sorbin and SH3 domain containing 3
SRPX sushi-repeat containing protein, X-linked
TBC1D16 TBC1 domain family, member 16
TCTA T-cell leukemia translocation altered
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM97 transmembrane protein 97
TSPYL5 TSPY-like 5
USP22 ubiquitin specific peptidase 22
VAT1 vesicle amine transport 1
WSB2 WD repeat and SOCS box containing 2
XYLT1 xylosyltransferase I
YBX3 Y box binding protein 3