BRD-K06792661_Narciclasine_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

303 genes differentially expressed following the BRD-K06792661_Narciclasine_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AKAP8L A kinase (PRKA) anchor protein 8-like
AKIRIN1 akirin 1
ARHGAP29 Rho GTPase activating protein 29
ARID4B AT rich interactive domain 4B (RBP1-like)
ARID5B AT rich interactive domain 5B (MRF1-like)
ATF3 activating transcription factor 3
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BIK BCL2-interacting killer (apoptosis-inducing)
BRD2 bromodomain containing 2
BTG2 BTG family, member 2
C1ORF27 chromosome 1 open reading frame 27
CCL20 chemokine (C-C motif) ligand 20
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCNL1 cyclin L1
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2AIP CDKN2A interacting protein
CHD1 chromodomain helicase DNA binding protein 1
CHIC2 cysteine-rich hydrophobic domain 2
CHMP1B charged multivesicular body protein 1B
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLK4 CDC-like kinase 4
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DAAM1 dishevelled associated activator of morphogenesis 1
DDIT3 DNA-damage-inducible transcript 3
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DUSP8 dual specificity phosphatase 8
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EFNA1 ephrin-A1
EFNB2 ephrin-B2
EGR1 early growth response 1
EGR3 early growth response 3
ELF1 E74-like factor 1 (ets domain transcription factor)
EMP1 epithelial membrane protein 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EZR ezrin
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM179B family with sequence similarity 179, member B
FAM53C family with sequence similarity 53, member C
FNBP4 formin binding protein 4
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
GLS glutaminase
GTF2B general transcription factor IIB
H1F0 H1 histone family, member 0
H2BFS H2B histone family, member S (pseudogene)
HBEGF heparin-binding EGF-like growth factor
HBP1 HMG-box transcription factor 1
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AE histone cluster 1, H2ae
HIST1H2AJ histone cluster 1, H2aj
HIST1H2AM histone cluster 1, H2am
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BI histone cluster 1, H2bi
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST1H4H histone cluster 1, H4h
HIST2H2BE histone cluster 2, H2be
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
ICAM1 intercellular adhesion molecule 1
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFRD1 interferon-related developmental regulator 1
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IGFBP3 insulin-like growth factor binding protein 3
INSIG1 insulin induced gene 1
ISG20 interferon stimulated exonuclease gene 20kDa
JMJD1C jumonji domain containing 1C
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KDM5B lysine (K)-specific demethylase 5B
KDM6A lysine (K)-specific demethylase 6A
KDM6B lysine (K)-specific demethylase 6B
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
KRT23 keratin 23, type I
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MCL1 myeloid cell leukemia 1
MED17 mediator complex subunit 17
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
ODC1 ornithine decarboxylase 1
OSER1 oxidative stress responsive serine-rich 1
PELI1 pellino E3 ubiquitin protein ligase 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLK2 polo-like kinase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRDM2 PR domain containing 2, with ZNF domain
PTBP2 polypyrimidine tract binding protein 2
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RAB5A RAB5A, member RAS oncogene family
RBM34 RNA binding motif protein 34
RBM39 RNA binding motif protein 39
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RLF rearranged L-myc fusion
RNMT RNA (guanine-7-) methyltransferase
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RSRC2 arginine/serine-rich coiled-coil 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SCAF8 SR-related CTD-associated factor 8
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SIRT1 sirtuin 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SOX9 SRY (sex determining region Y)-box 9
SPAG9 sperm associated antigen 9
SREK1 splicing regulatory glutamine/lysine-rich protein 1
SRSF11 serine/arginine-rich splicing factor 11
SRSF7 serine/arginine-rich splicing factor 7
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TEX10 testis expressed 10
TFB2M transcription factor B2, mitochondrial
THUMPD2 THUMP domain containing 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKTL1 transketolase-like 1
TNC tenascin C
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae)
TSC22D1 TSC22 domain family, member 1
TSC22D2 TSC22 domain family, member 2
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
TXNL4B thioredoxin-like 4B
UBE2H ubiquitin-conjugating enzyme E2H
USP15 ubiquitin specific peptidase 15
VNN1 vanin 1
VTCN1 V-set domain containing T cell activation inhibitor 1
WSB1 WD repeat and SOCS box containing 1
YTHDC1 YTH domain containing 1
ZBTB10 zinc finger and BTB domain containing 10
ZC3H12A zinc finger CCCH-type containing 12A
ZC3H15 zinc finger CCCH-type containing 15
ZFAND5 zinc finger, AN1-type domain 5
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF24 zinc finger protein 24
ZNF274 zinc finger protein 274
ZNF410 zinc finger protein 410

decreased expression

Symbol Name
AARS alanyl-tRNA synthetase
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ADCY9 adenylate cyclase 9
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ANXA4 annexin A4
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
AUTS2 autism susceptibility candidate 2
AXL AXL receptor tyrosine kinase
B3GNT1
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BASP1 brain abundant, membrane attached signal protein 1
C1QB complement component 1, q subcomponent, B chain
CA12 carbonic anhydrase XII
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CARM1 coactivator-associated arginine methyltransferase 1
CBS cystathionine-beta-synthase
CCNA2 cyclin A2
CCND1 cyclin D1
CCNF cyclin F
CCR1 chemokine (C-C motif) receptor 1
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD14 CD14 molecule
CD163 CD163 molecule
CERK ceramide kinase
CLCA4 chloride channel accessory 4
CPOX coproporphyrinogen oxidase
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CYB5R3 cytochrome b5 reductase 3
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DEFB1 defensin, beta 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
DUSP4 dual specificity phosphatase 4
DUSP7 dual specificity phosphatase 7
EIF4B eukaryotic translation initiation factor 4B
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ERBB3 erb-b2 receptor tyrosine kinase 3
FAM20B family with sequence similarity 20, member B
FAM57A family with sequence similarity 57, member A
FAM64A family with sequence similarity 64, member A
FCGBP Fc fragment of IgG binding protein
FGFR3 fibroblast growth factor receptor 3
FZD2 frizzled class receptor 2
G6PD glucose-6-phosphate dehydrogenase
GAS2L1 growth arrest-specific 2 like 1
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
HOXB7 homeobox B7
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ICMT isoprenylcysteine carboxyl methyltransferase
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDO1 indoleamine 2,3-dioxygenase 1
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KANK2 KN motif and ankyrin repeat domains 2
KAZN kazrin, periplakin interacting protein
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KEAP1 kelch-like ECH-associated protein 1
KIAA0930 KIAA0930
KRT18 keratin 18, type I
LBR lamin B receptor
LMNB1 lamin B1
LMNB2 lamin B2
MAP1B microtubule-associated protein 1B
MCM2 minichromosome maintenance complex component 2
MEGF9 multiple EGF-like-domains 9
MRPL34 mitochondrial ribosomal protein L34
MSRB1 methionine sulfoxide reductase B1
NCOR2 nuclear receptor corepressor 2
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NME4 NME/NM23 nucleoside diphosphate kinase 4
NQO1 NAD(P)H dehydrogenase, quinone 1
NR2F6 nuclear receptor subfamily 2, group F, member 6
NUP62 nucleoporin 62kDa
NXN nucleoredoxin
OLFM4 olfactomedin 4
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PEBP1 phosphatidylethanolamine binding protein 1
PGAM1 phosphoglycerate mutase 1 (brain)
PIR pirin (iron-binding nuclear protein)
PODXL podocalyxin-like
PPAP2C phosphatidic acid phosphatase type 2C
PSAT1 phosphoserine aminotransferase 1
PSCA prostate stem cell antigen
PTGIS prostaglandin I2 (prostacyclin) synthase
PTP4A2 protein tyrosine phosphatase type IVA, member 2
RPL27A ribosomal protein L27a
RPS11 ribosomal protein S11
RXRA retinoid X receptor, alpha
SAC3D1 SAC3 domain containing 1
SAP30 Sin3A-associated protein, 30kDa
SCGB2A1 secretoglobin, family 2A, member 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPT10 septin 10
SEPT11 septin 11
SET SET nuclear proto-oncogene
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TBC1D16 TBC1 domain family, member 16
TBC1D2B TBC1 domain family, member 2B
TBL1X transducin (beta)-like 1X-linked
TFDP1 transcription factor Dp-1
TGM2 transglutaminase 2
TMEM47 transmembrane protein 47
TMEM97 transmembrane protein 97
TUBB tubulin, beta class I
TUBG1 tubulin, gamma 1
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1
WNT5A wingless-type MMTV integration site family, member 5A
WSB2 WD repeat and SOCS box containing 2
XYLT1 xylosyltransferase I