BRD-K06765193_(E)-2-(1H-Benzoimidazol-2-yl)-3-(5-nitro-furan-2-yl)-acrylonitrile BRD-K06765193_VCAP_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

55 genes differentially expressed following the BRD-K06765193_(E)-2-(1H-Benzoimidazol-2-yl)-3-(5-nitro-furan-2-yl)-acrylonitrile BRD-K06765193_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
CBR3 carbonyl reductase 3
CD163 CD163 molecule
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CSRP1 cysteine and glycine-rich protein 1
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
GCLM glutamate-cysteine ligase, modifier subunit
GLUL glutamate-ammonia ligase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IER5 immediate early response 5
IL1R2 interleukin 1 receptor, type II
INSIG1 insulin induced gene 1
JMJD6 jumonji domain containing 6
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MSMO1 methylsterol monooxygenase 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NQO1 NAD(P)H dehydrogenase, quinone 1
NRCAM neuronal cell adhesion molecule
NRIP1 nuclear receptor interacting protein 1
OSER1 oxidative stress responsive serine-rich 1
PIR pirin (iron-binding nuclear protein)
PLIN2 perilipin 2
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PTX3 pentraxin 3, long
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
TALDO1 transaldolase 1
TKT transketolase
TUBB2A tubulin, beta 2A class IIa
TXNRD1 thioredoxin reductase 1
UGDH UDP-glucose 6-dehydrogenase

decreased expression

Symbol Name
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
APOD apolipoprotein D
B3GNT1
CNPY3 canopy FGF signaling regulator 3
CTSH cathepsin H
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
IGF1R insulin-like growth factor 1 receptor
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
MLPH melanophilin
MYC v-myc avian myelocytomatosis viral oncogene homolog
SOX4 SRY (sex determining region Y)-box 4
SVIL supervillin
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)