BRD-K06765193_(E)-2-(1H-Benzoimidazol-2-yl)-3-(5-nitro-furan-2-yl)-acrylonitrile BRD-K06765193_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

56 genes differentially expressed following the BRD-K06765193_(E)-2-(1H-Benzoimidazol-2-yl)-3-(5-nitro-furan-2-yl)-acrylonitrile BRD-K06765193_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C2 aldo-keto reductase family 1, member C2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BTG1 B-cell translocation gene 1, anti-proliferative
CA2 carbonic anhydrase II
CBR1 carbonyl reductase 1
CBR3 carbonyl reductase 3
CD36 CD36 molecule (thrombospondin receptor)
CLEC2B C-type lectin domain family 2, member B
CRABP2 cellular retinoic acid binding protein 2
FABP4 fatty acid binding protein 4, adipocyte
FN1 fibronectin 1
G6PD glucose-6-phosphate dehydrogenase
HMOX1 heme oxygenase 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
LPXN leupaxin
LRP10 low density lipoprotein receptor-related protein 10
MSN moesin
MT1E metallothionein 1E
MT1F metallothionein 1F
NQO1 NAD(P)H dehydrogenase, quinone 1
PDIA3 protein disulfide isomerase family A, member 3
PLIN2 perilipin 2
PLK1 polo-like kinase 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SCGB2A2 secretoglobin, family 2A, member 2
SGK1 serum/glucocorticoid regulated kinase 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TXNRD1 thioredoxin reductase 1
VAT1 vesicle amine transport 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
AUTS2 autism susceptibility candidate 2
CD44 CD44 molecule (Indian blood group)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FERMT1 fermitin family member 1
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KDM5D lysine (K)-specific demethylase 5D
KLK11 kallikrein-related peptidase 11
LAMA3 laminin, alpha 3
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LOXL1 lysyl oxidase-like 1
MCM6 minichromosome maintenance complex component 6
MET MET proto-oncogene, receptor tyrosine kinase
MMP12 matrix metallopeptidase 12
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO5C myosin VC
OXCT1 3-oxoacid CoA transferase 1
PCNA proliferating cell nuclear antigen
PCP4 Purkinje cell protein 4
PLCB4 phospholipase C, beta 4
ST7 suppression of tumorigenicity 7
TARBP1 TAR (HIV-1) RNA binding protein 1
TRIM29 tripartite motif containing 29
TSPAN8 tetraspanin 8