BRD-K06765193_(E)-2-(1H-Benzoimidazol-2-yl)-3-(5-nitro-furan-2-yl)-acrylonitrile BRD-K06765193_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

168 genes differentially expressed following the BRD-K06765193_(E)-2-(1H-Benzoimidazol-2-yl)-3-(5-nitro-furan-2-yl)-acrylonitrile BRD-K06765193_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BCAT1 branched chain amino-acid transaminase 1, cytosolic
CD163 CD163 molecule
CD93 CD93 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHIC2 cysteine-rich hydrophobic domain 2
CORO1A coronin, actin binding protein, 1A
DCLK1 doublecortin-like kinase 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DIO2 deiodinase, iodothyronine, type II
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
EPAS1 endothelial PAS domain protein 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FOSL1 FOS-like antigen 1
FXR1 fragile X mental retardation, autosomal homolog 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GAL galanin/GMAP prepropeptide
GCLM glutamate-cysteine ligase, modifier subunit
GEM GTP binding protein overexpressed in skeletal muscle
GULP1 GULP, engulfment adaptor PTB domain containing 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IL13RA2 interleukin 13 receptor, alpha 2
JAG1 jagged 1
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KRT14 keratin 14, type I
KRT6B keratin 6B, type II
KYNU kynureninase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1B microtubule-associated protein 1B
MBNL2 muscleblind-like splicing regulator 2
MEF2C myocyte enhancer factor 2C
MIR22HG MIR22 host gene
MMP2 matrix metallopeptidase 2
MT1M metallothionein 1M
MUC5B mucin 5B, oligomeric mucus/gel-forming
NID1 nidogen 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NRCAM neuronal cell adhesion molecule
NXF1 nuclear RNA export factor 1
OSER1 oxidative stress responsive serine-rich 1
PCSK1 proprotein convertase subtilisin/kexin type 1
PELI1 pellino E3 ubiquitin protein ligase 1
PELO pelota homolog (Drosophila)
PLEKHO1 pleckstrin homology domain containing, family O member 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PMP22 peripheral myelin protein 22
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTHLH parathyroid hormone-like hormone
PTRF polymerase I and transcript release factor
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
RND3 Rho family GTPase 3
S100P S100 calcium binding protein P
SCG5 secretogranin V
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SGK1 serum/glucocorticoid regulated kinase 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SNAI2 snail family zinc finger 2
SNX7 sorting nexin 7
SPRR1A small proline-rich protein 1A
SPRR3 small proline-rich protein 3
TACC2 transforming, acidic coiled-coil containing protein 2
TES testin LIM domain protein
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TUBA4A tubulin, alpha 4a
TUBB2A tubulin, beta 2A class IIa
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACSF2 acyl-CoA synthetase family member 2
ACSL1 acyl-CoA synthetase long-chain family member 1
ADD3 adducin 3 (gamma)
ADIRF adipogenesis regulatory factor
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALB albumin
ALDOB aldolase B, fructose-bisphosphate
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
APOA1 apolipoprotein A-I
APOA2 apolipoprotein A-II
B3GNT1
BEX1 brain expressed, X-linked 1
C2CD2 C2 calcium-dependent domain containing 2
CCNA2 cyclin A2
CCNF cyclin F
CDC20 cell division cycle 20
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CES1 carboxylesterase 1
COG2 component of oligomeric golgi complex 2
CPOX coproporphyrinogen oxidase
CPVL carboxypeptidase, vitellogenic-like
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DEFB1 defensin, beta 1
DHCR24 24-dehydrocholesterol reductase
DHRS11 dehydrogenase/reductase (SDR family) member 11
EPHA3 EPH receptor A3
ERBB2 erb-b2 receptor tyrosine kinase 2
FABP1 fatty acid binding protein 1, liver
FGB fibrinogen beta chain
FOLR1 folate receptor 1 (adult)
FZD7 frizzled class receptor 7
GDE1 glycerophosphodiester phosphodiesterase 1
HOXC6 homeobox C6
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
KIF20A kinesin family member 20A
KNG1 kininogen 1
LEPR leptin receptor
MAMLD1 mastermind-like domain containing 1
MARCKSL1 MARCKS-like 1
MGP matrix Gla protein
NNT nicotinamide nucleotide transhydrogenase
NPY1R neuropeptide Y receptor Y1
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4
PCCB propionyl CoA carboxylase, beta polypeptide
PCP4 Purkinje cell protein 4
PEG10 paternally expressed 10
PGM1 phosphoglucomutase 1
PTTG1 pituitary tumor-transforming 1
QDPR quinoid dihydropteridine reductase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
S100A8 S100 calcium binding protein A8
SCUBE2 signal peptide, CUB domain, EGF-like 2
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TF transferrin
TGFBR3 transforming growth factor, beta receptor III
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM1 tropomyosin 1 (alpha)
TSPAN3 tetraspanin 3
TTR transthyretin
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28