BRD-K06765193_(E)-2-(1H-Benzoimidazol-2-yl)-3-(5-nitro-furan-2-yl)-acrylonitrile BRD-K06765193_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

132 genes differentially expressed following the BRD-K06765193_(E)-2-(1H-Benzoimidazol-2-yl)-3-(5-nitro-furan-2-yl)-acrylonitrile BRD-K06765193_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ANKRD12 ankyrin repeat domain 12
ANO1 anoctamin 1, calcium activated chloride channel
ARMCX3 armadillo repeat containing, X-linked 3
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BTG2 BTG family, member 2
C1ORF54 chromosome 1 open reading frame 54
C1QB complement component 1, q subcomponent, B chain
CBR3 carbonyl reductase 3
CCR7 chemokine (C-C motif) receptor 7
CD163 CD163 molecule
CD4 CD4 molecule
COL4A5 collagen, type IV, alpha 5
CTSL cathepsin L
DDIT3 DNA-damage-inducible transcript 3
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP2 dual specificity phosphatase 2
EFS embryonal Fyn-associated substrate
EGR1 early growth response 1
EGR2 early growth response 2
FASTKD5 FAST kinase domains 5
FOS FBJ murine osteosarcoma viral oncogene homolog
FZD7 frizzled class receptor 7
G6PD glucose-6-phosphate dehydrogenase
GCLM glutamate-cysteine ligase, modifier subunit
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GPX2 glutathione peroxidase 2
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IKZF1 IKAROS family zinc finger 1 (Ikaros)
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KEAP1 kelch-like ECH-associated protein 1
KRT5 keratin 5, type II
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MIR22HG MIR22 host gene
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MTSS1 metastasis suppressor 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
PIR pirin (iron-binding nuclear protein)
PLAGL2 pleiomorphic adenoma gene-like 2
PLD3 phospholipase D family, member 3
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTN pleiotrophin
RNF167 ring finger protein 167
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SFN stratifin
SFTPB surfactant protein B
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNX11 sorting nexin 11
SQSTM1 sequestosome 1
TACSTD2 tumor-associated calcium signal transducer 2
TIMP3 TIMP metallopeptidase inhibitor 3
TXNRD1 thioredoxin reductase 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ADA adenosine deaminase
ALDOB aldolase B, fructose-bisphosphate
AMIGO2 adhesion molecule with Ig-like domain 2
ASS1 argininosuccinate synthase 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCDC109B coiled-coil domain containing 109B
CFH complement factor H
CKLF chemokine-like factor
CP ceruloplasmin (ferroxidase)
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CRIP1 cysteine-rich protein 1 (intestinal)
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPYSL3 dihydropyrimidinase-like 3
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
FHL1 four and a half LIM domains 1
FXYD5 FXYD domain containing ion transport regulator 5
G0S2 G0/G1 switch 2
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
HEG1 heart development protein with EGF-like domains 1
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
ITM2C integral membrane protein 2C
KRT7 keratin 7, type II
KRT8 keratin 8, type II
LEPR leptin receptor
LUM lumican
LXN latexin
LY6E lymphocyte antigen 6 complex, locus E
LYPLA1 lysophospholipase I
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP7 microtubule-associated protein 7
MRPL15 mitochondrial ribosomal protein L15
NEBL nebulette
NFIB nuclear factor I/B
NNMT nicotinamide N-methyltransferase
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCNA proliferating cell nuclear antigen
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PNMA2 paraneoplastic Ma antigen 2
PXDN peroxidasin
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK1 serine peptidase inhibitor, Kazal type 1
SST somatostatin
SULF1 sulfatase 1
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TF transferrin
TFRC transferrin receptor
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TNS3 tensin 3
TRIM14 tripartite motif containing 14
TYMS thymidylate synthetase
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VCAN versican
VNN1 vanin 1