BRD-K06765193_(E)-2-(1H-Benzoimidazol-2-yl)-3-(5-nitro-furan-2-yl)-acrylonitrile BRD-K06765193_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

96 genes differentially expressed following the BRD-K06765193_(E)-2-(1H-Benzoimidazol-2-yl)-3-(5-nitro-furan-2-yl)-acrylonitrile BRD-K06765193_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ANKRD12 ankyrin repeat domain 12
ARC activity-regulated cytoskeleton-associated protein
ATF3 activating transcription factor 3
CD52 CD52 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L2 chitinase 3-like 2
CKS2 CDC28 protein kinase regulatory subunit 2
CLU clusterin
CTH cystathionine gamma-lyase
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DUSP5 dual specificity phosphatase 5
ELANE elastase, neutrophil expressed
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GAL galanin/GMAP prepropeptide
GCH1 GTP cyclohydrolase 1
GPM6B glycoprotein M6B
GREB1 growth regulation by estrogen in breast cancer 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
H2BFS H2B histone family, member S (pseudogene)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
JUN jun proto-oncogene
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEG3 maternally expressed 3 (non-protein coding)
MIR22HG MIR22 host gene
NCOA3 nuclear receptor coactivator 3
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PTP4A1 protein tyrosine phosphatase type IVA, member 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SRGN serglycin
STC2 stanniocalcin 2
TUFT1 tuftelin 1
XBP1 X-box binding protein 1
ZFP36 ZFP36 ring finger protein
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ACP6 acid phosphatase 6, lysophosphatidic
CAV1 caveolin 1, caveolae protein, 22kDa
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DUSP6 dual specificity phosphatase 6
EFNB2 ephrin-B2
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ERBB3 erb-b2 receptor tyrosine kinase 3
EXT1 exostosin glycosyltransferase 1
FABP4 fatty acid binding protein 4, adipocyte
FLRT2 fibronectin leucine rich transmembrane protein 2
FST follistatin
HMGA2 high mobility group AT-hook 2
IFI16 interferon, gamma-inducible protein 16
IL27RA interleukin 27 receptor, alpha
IRS1 insulin receptor substrate 1
ISOC1 isochorismatase domain containing 1
KRT7 keratin 7, type II
LAMB1 laminin, beta 1
LGALS1 lectin, galactoside-binding, soluble, 1
LRP4 low density lipoprotein receptor-related protein 4
MARCKSL1 MARCKS-like 1
MOK MOK protein kinase
MRPL15 mitochondrial ribosomal protein L15
NR2F1 nuclear receptor subfamily 2, group F, member 1
OLFM4 olfactomedin 4
OSBPL10 oxysterol binding protein-like 10
PPARG peroxisome proliferator-activated receptor gamma
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PSPH phosphoserine phosphatase
RFC5 replication factor C (activator 1) 5, 36.5kDa
RGS5 regulator of G-protein signaling 5
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TARBP1 TAR (HIV-1) RNA binding protein 1
TFPI2 tissue factor pathway inhibitor 2
TGFA transforming growth factor, alpha
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TM4SF1 transmembrane 4 L six family member 1
TNS3 tensin 3
VCAN versican