BRD-K06750613_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

198 genes differentially expressed following the BRD-K06750613_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
ALB albumin
AMIGO2 adhesion molecule with Ig-like domain 2
ANGPTL2 angiopoietin-like 2
ARID4B AT rich interactive domain 4B (RBP1-like)
ATG12 autophagy related 12
BCL2A1 BCL2-related protein A1
BGN biglycan
BLNK B-cell linker
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
CCNG2 cyclin G2
CD300A CD300a molecule
CD52 CD52 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CHN1 chimerin 1
CLEC2B C-type lectin domain family 2, member B
CPE carboxypeptidase E
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL9 chemokine (C-X-C motif) ligand 9
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
CYTH1 cytohesin 1
DARS aspartyl-tRNA synthetase
DBT dihydrolipoamide branched chain transacylase E2
DDIT3 DNA-damage-inducible transcript 3
DENND2D DENN/MADD domain containing 2D
DOCK4 dedicator of cytokinesis 4
DPYSL3 dihydropyrimidinase-like 3
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
EIF5 eukaryotic translation initiation factor 5
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPAS1 endothelial PAS domain protein 1
EVI2A ecotropic viral integration site 2A
FBXL12 F-box and leucine-rich repeat protein 12
FZD5 frizzled class receptor 5
GBP2 guanylate binding protein 2, interferon-inducible
GNLY granulysin
GREM1 gremlin 1, DAN family BMP antagonist
GSDMB gasdermin B
HBP1 HMG-box transcription factor 1
HECA headcase homolog (Drosophila)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BG histone cluster 1, H2bg
HMOX1 heme oxygenase 1
HOMER3 homer scaffolding protein 3
HOPX HOP homeobox
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFRD1 interferon-related developmental regulator 1
IGFBP5 insulin-like growth factor binding protein 5
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IL13RA1 interleukin 13 receptor, alpha 1
ISOC1 isochorismatase domain containing 1
KIAA0907 KIAA0907
LCK LCK proto-oncogene, Src family tyrosine kinase
LRMP lymphoid-restricted membrane protein
LUM lumican
LYZ lysozyme
MAP7 microtubule-associated protein 7
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MTERF3 mitochondrial transcription termination factor 3
MTSS1 metastasis suppressor 1
MXRA5 matrix-remodelling associated 5
N4BP2L2 NEDD4 binding protein 2-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NOX4 NADPH oxidase 4
PDE4C phosphodiesterase 4C, cAMP-specific
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)
PSD3 pleckstrin and Sec7 domain containing 3
PTPRC protein tyrosine phosphatase, receptor type, C
PTPRK protein tyrosine phosphatase, receptor type, K
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
RABGAP1L RAB GTPase activating protein 1-like
RAD21 RAD21 homolog (S. pombe)
RAP1GAP2 RAP1 GTPase activating protein 2
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
RGS5 regulator of G-protein signaling 5
RIOK3 RIO kinase 3
RSRP1 arginine/serine-rich protein 1
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC35E1 solute carrier family 35, member E1
SLC38A2 solute carrier family 38, member 2
SNX13 sorting nexin 13
SOX2 SRY (sex determining region Y)-box 2
SOX4 SRY (sex determining region Y)-box 4
STON1 stonin 1
SULF1 sulfatase 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TBC1D15 TBC1 domain family, member 15
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TDO2 tryptophan 2,3-dioxygenase
THBS2 thrombospondin 2
TMEM135 transmembrane protein 135
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TPD52 tumor protein D52
TRDV3 T cell receptor delta variable 3
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
TRPS1 trichorhinophalangeal syndrome I
TSC22D3 TSC22 domain family, member 3
TXNL4B thioredoxin-like 4B
UBR2 ubiquitin protein ligase E3 component n-recognin 2
VEGFA vascular endothelial growth factor A
VNN1 vanin 1
XIST X inactive specific transcript (non-protein coding)
ZNF430 zinc finger protein 430
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADGRG2 adhesion G protein-coupled receptor G2
AKAP12 A kinase (PRKA) anchor protein 12
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALOX5 arachidonate 5-lipoxygenase
AQP3 aquaporin 3 (Gill blood group)
ASS1 argininosuccinate synthase 1
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
B3GNT1
BAG3 BCL2-associated athanogene 3
BLCAP bladder cancer associated protein
BZW2 basic leucine zipper and W2 domains 2
CCND3 cyclin D3
CD151 CD151 molecule (Raph blood group)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CKAP4 cytoskeleton-associated protein 4
CLN5 ceroid-lipofuscinosis, neuronal 5
CRYAB crystallin, alpha B
CYTL1 cytokine-like 1
DCBLD2 discoidin, CUB and LCCL domain containing 2
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
ECI2 enoyl-CoA delta isomerase 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENO1 enolase 1, (alpha)
EPHA2 EPH receptor A2
FAM216A family with sequence similarity 216, member A
FGF9 fibroblast growth factor 9
FKBP10 FK506 binding protein 10, 65 kDa
FOSL1 FOS-like antigen 1
GEM GTP binding protein overexpressed in skeletal muscle
GNAS GNAS complex locus
GPI glucose-6-phosphate isomerase
GPX3 glutathione peroxidase 3
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPB8 heat shock 22kDa protein 8
KANK2 KN motif and ankyrin repeat domains 2
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KDM5D lysine (K)-specific demethylase 5D
LBR lamin B receptor
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIF leukemia inhibitory factor
LOXL1 lysyl oxidase-like 1
MAGED1 melanoma antigen family D1
MAP2K3 mitogen-activated protein kinase kinase 3
MAT2A methionine adenosyltransferase II, alpha
MET MET proto-oncogene, receptor tyrosine kinase
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MRPS2 mitochondrial ribosomal protein S2
NDN necdin, melanoma antigen (MAGE) family member
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR1H2 nuclear receptor subfamily 1, group H, member 2
NRN1 neuritin 1
PAX8 paired box 8
PEBP1 phosphatidylethanolamine binding protein 1
PI3 peptidase inhibitor 3, skin-derived
PKM pyruvate kinase, muscle
PNP purine nucleoside phosphorylase
PTGDS prostaglandin D2 synthase 21kDa (brain)
RNASET2 ribonuclease T2
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A2 S100 calcium binding protein A2
SACS sacsin molecular chaperone
SETBP1 SET binding protein 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLIT2 slit homolog 2 (Drosophila)
SLPI secretory leukocyte peptidase inhibitor
SPATS2L spermatogenesis associated, serine-rich 2-like
SPINK5 serine peptidase inhibitor, Kazal type 5
STAMBP STAM binding protein
TACSTD2 tumor-associated calcium signal transducer 2
TCF4 transcription factor 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TNC tenascin C
TOMM34 translocase of outer mitochondrial membrane 34
TRAPPC3 trafficking protein particle complex 3
WFDC2 WAP four-disulfide core domain 2