BRD-K06593056_-666_SW620_6.0_h_20.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

188 genes differentially expressed following the BRD-K06593056_-666_SW620_6.0_h_20.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AMIGO2 adhesion molecule with Ig-like domain 2
ANKRD11 ankyrin repeat domain 11
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARL14 ADP-ribosylation factor-like 14
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPN asporin
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BEX1 brain expressed, X-linked 1
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
CARS cysteinyl-tRNA synthetase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COL11A1 collagen, type XI, alpha 1
COMP cartilage oligomeric matrix protein
CTGF connective tissue growth factor
CTH cystathionine gamma-lyase
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DSP desmoplakin
DST dystonin
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EGR3 early growth response 3
EIF5 eukaryotic translation initiation factor 5
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EREG epiregulin
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EZR ezrin
F2RL1 coagulation factor II (thrombin) receptor-like 1
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FOXO3 forkhead box O3
FST follistatin
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GLS glutaminase
GPRC5A G protein-coupled receptor, class C, group 5, member A
H1F0 H1 histone family, member 0
HIST1H2AC histone cluster 1, H2ac
HMOX1 heme oxygenase 1
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
IGF1R insulin-like growth factor 1 receptor
IGFBP1 insulin-like growth factor binding protein 1
INHBA inhibin, beta A
INHBE inhibin, beta E
IRS1 insulin receptor substrate 1
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT6B keratin 6B, type II
KRT81 keratin 81, type II
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCL1 myeloid cell leukemia 1
NFIL3 nuclear factor, interleukin 3 regulated
NPAS2 neuronal PAS domain protein 2
PER1 period circadian clock 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POU2AF1 POU class 2 associating factor 1
PRSS23 protease, serine, 23
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RND3 Rho family GTPase 3
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
S100A2 S100 calcium binding protein A2
SARS seryl-tRNA synthetase
SDC1 syndecan 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SIK1 salt-inducible kinase 1
SLC38A1 solute carrier family 38, member 1
SNAI2 snail family zinc finger 2
SPRR1A small proline-rich protein 1A
SQSTM1 sequestosome 1
SRPK2 SRSF protein kinase 2
SULF1 sulfatase 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFF1 trefoil factor 1
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TIAM1 T-cell lymphoma invasion and metastasis 1
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TP63 tumor protein p63
TUBB2A tubulin, beta 2A class IIa
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
WISP2 WNT1 inducible signaling pathway protein 2
XBP1 X-box binding protein 1
ZFAND5 zinc finger, AN1-type domain 5
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2
ZMIZ1 zinc finger, MIZ-type containing 1

decreased expression

Symbol Name
ACSL5 acyl-CoA synthetase long-chain family member 5
ADCY9 adenylate cyclase 9
B3GNT1
BIRC5 baculoviral IAP repeat containing 5
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCNA2 cyclin A2
CCNF cyclin F
CD320 CD320 molecule
CD99 CD99 molecule
CDC20 cell division cycle 20
CDK1 cyclin-dependent kinase 1
CES1 carboxylesterase 1
COL3A1 collagen, type III, alpha 1
CTSH cathepsin H
CYTL1 cytokine-like 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPM6A glycoprotein M6A
GRWD1 glutamate-rich WD repeat containing 1
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
LMO2 LIM domain only 2 (rhombotin-like 1)
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MCAM melanoma cell adhesion molecule
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
NME4 NME/NM23 nucleoside diphosphate kinase 4
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUP62 nucleoporin 62kDa
PDGFA platelet-derived growth factor alpha polypeptide
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLK1 polo-like kinase 1
PTDSS1 phosphatidylserine synthase 1
RASIP1 Ras interacting protein 1
RBP1 retinol binding protein 1, cellular
RPA1 replication protein A1, 70kDa
S100A8 S100 calcium binding protein A8
SCARB2 scavenger receptor class B, member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC39A8 solute carrier family 39 (zinc transporter), member 8
TMEM106C transmembrane protein 106C
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSPAN12 tetraspanin 12
TYROBP TYRO protein tyrosine kinase binding protein
UBE2C ubiquitin-conjugating enzyme E2C
WFS1 Wolfram syndrome 1 (wolframin)
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon