BRD-K06593056_-666_HA1E_24.0_h_20.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

184 genes differentially expressed following the BRD-K06593056_-666_HA1E_24.0_h_20.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
AARS alanyl-tRNA synthetase
ADGRG6 adhesion G protein-coupled receptor G6
AMIGO2 adhesion molecule with Ig-like domain 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
BID BH3 interacting domain death agonist
CA2 carbonic anhydrase II
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CCDC109B coiled-coil domain containing 109B
CCND2 cyclin D2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CTH cystathionine gamma-lyase
CYBB cytochrome b-245, beta polypeptide
DDIT3 DNA-damage-inducible transcript 3
DENND1B DENN/MADD domain containing 1B
DFNA5 deafness, autosomal dominant 5
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EPRS glutamyl-prolyl-tRNA synthetase
ETV5 ets variant 5
FCGBP Fc fragment of IgG binding protein
GADD45A growth arrest and DNA-damage-inducible, alpha
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
GK glycerol kinase
GLRX glutaredoxin (thioltransferase)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
HECA headcase homolog (Drosophila)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HSPA1A heat shock 70kDa protein 1A
HSPA9 heat shock 70kDa protein 9 (mortalin)
IARS isoleucyl-tRNA synthetase
IFRD1 interferon-related developmental regulator 1
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
ITK IL2-inducible T-cell kinase
LIMCH1 LIM and calponin homology domains 1
LY96 lymphocyte antigen 96
MARS methionyl-tRNA synthetase
MME membrane metallo-endopeptidase
MMP9 matrix metallopeptidase 9
MOCOS molybdenum cofactor sulfurase
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYH11 myosin, heavy chain 11, smooth muscle
NARS asparaginyl-tRNA synthetase
NDRG2 NDRG family member 2
NELL2 NEL-like 2 (chicken)
NT5E 5'-nucleotidase, ecto (CD73)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFA platelet-derived growth factor alpha polypeptide
PHGDH phosphoglycerate dehydrogenase
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRNP prion protein
PSAT1 phosphoserine aminotransferase 1
PYCR1 pyrroline-5-carboxylate reductase 1
RFTN1 raftlin, lipid raft linker 1
RGS1 regulator of G-protein signaling 1
RGS10 regulator of G-protein signaling 10
RPS4Y1 ribosomal protein S4, Y-linked 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RTN1 reticulon 1
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SH2B3 SH2B adaptor protein 3
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC38A2 solute carrier family 38, member 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
TBX2 T-box 2
TGFA transforming growth factor, alpha
TRBC1 T cell receptor beta constant 1
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TXNRD1 thioredoxin reductase 1
WARS tryptophanyl-tRNA synthetase
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ACKR3 atypical chemokine receptor 3
ADD3 adducin 3 (gamma)
ALDOA aldolase A, fructose-bisphosphate
ALDOC aldolase C, fructose-bisphosphate
ANXA3 annexin A3
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
BNC2 basonuclin 2
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CA9 carbonic anhydrase IX
CCL2 chemokine (C-C motif) ligand 2
CD24 CD24 molecule
CD58 CD58 molecule
CDC42 cell division cycle 42
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CETN2 centrin, EF-hand protein, 2
CFI complement factor I
COL5A1 collagen, type V, alpha 1
CRIP1 cysteine-rich protein 1 (intestinal)
CTSV cathepsin V
DCK deoxycytidine kinase
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNB2 ephrin-B2
EGLN3 egl-9 family hypoxia-inducible factor 3
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHB2 EPH receptor B2
ERAP2 endoplasmic reticulum aminopeptidase 2
FAM46A family with sequence similarity 46, member A
FKBP14 FK506 binding protein 14, 22 kDa
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GJA1 gap junction protein, alpha 1, 43kDa
GPX3 glutathione peroxidase 3
GSTA4 glutathione S-transferase alpha 4
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
H3F3B H3 histone, family 3B (H3.3B)
HILPDA hypoxia inducible lipid droplet-associated
HIST1H2BD histone cluster 1, H2bd
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HN1 hematological and neurological expressed 1
HOXA5 homeobox A5
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI27 interferon, alpha-inducible protein 27
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGFBP3 insulin-like growth factor binding protein 3
INSIG1 insulin induced gene 1
KDM4B lysine (K)-specific demethylase 4B
KLF10 Kruppel-like factor 10
LAGE3 L antigen family, member 3
LAPTM4B lysosomal protein transmembrane 4 beta
LIPA lipase A, lysosomal acid, cholesterol esterase
LOX lysyl oxidase
LYPD1 LY6/PLAUR domain containing 1
MARCKSL1 MARCKS-like 1
MFAP2 microfibrillar-associated protein 2
MLEC malectin
MYBPC1 myosin binding protein C, slow type
NNMT nicotinamide N-methyltransferase
NPR3 natriuretic peptide receptor 3
NREP neuronal regeneration related protein
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDLIM1 PDZ and LIM domain 1
PEG10 paternally expressed 10
PGK1 phosphoglycerate kinase 1
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PLA2G15 phospholipase A2, group XV
PLAGL1 pleiomorphic adenoma gene-like 1
PLIN2 perilipin 2
PRKCDBP protein kinase C, delta binding protein
PRSS23 protease, serine, 23
RBP1 retinol binding protein 1, cellular
RPL37A ribosomal protein L37a
S100A10 S100 calcium binding protein A10
SCAND1 SCAN domain containing 1
SEPP1 selenoprotein P, plasma, 1
SFN stratifin
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SORD sorbitol dehydrogenase
SOX4 SRY (sex determining region Y)-box 4
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPRR1A small proline-rich protein 1A
SQLE squalene epoxidase
TMEM14A transmembrane protein 14A
TMEM164 transmembrane protein 164
ZMIZ1 zinc finger, MIZ-type containing 1