BRD-K06569345_HG-5-88-01_MCF10A_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

185 genes differentially expressed following the BRD-K06569345_HG-5-88-01_MCF10A_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ANPEP alanyl (membrane) aminopeptidase
ANXA1 annexin A1
ANXA2 annexin A2
ARHGAP29 Rho GTPase activating protein 29
ARL4A ADP-ribosylation factor-like 4A
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BASP1 brain abundant, membrane attached signal protein 1
C3 complement component 3
CD24 CD24 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD81 CD81 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFD complement factor D (adipsin)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLU clusterin
CP ceruloplasmin (ferroxidase)
CST3 cystatin C
CSTA cystatin A (stefin A)
CTTN cortactin
CXCL12 chemokine (C-X-C motif) ligand 12
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DEFB1 defensin, beta 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EHD2 EH-domain containing 2
EPAS1 endothelial PAS domain protein 1
FGFR2 fibroblast growth factor receptor 2
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GLDC glycine dehydrogenase (decarboxylating)
GLRX glutaredoxin (thioltransferase)
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GPATCH8 G patch domain containing 8
GPRC5B G protein-coupled receptor, class C, group 5, member B
GSTA1 glutathione S-transferase alpha 1
HBE1 hemoglobin, epsilon 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRA major histocompatibility complex, class II, DR alpha
IGL immunoglobulin lambda locus
JUP junction plakoglobin
KCNK3 potassium channel, two pore domain subfamily K, member 3
KRT15 keratin 15, type I
KRT18 keratin 18, type I
KRT19 keratin 19, type I
KRT23 keratin 23, type I
KRT7 keratin 7, type II
LGALS2 lectin, galactoside-binding, soluble, 2
LGALS3 lectin, galactoside-binding, soluble, 3
LTF lactotransferrin
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MET MET proto-oncogene, receptor tyrosine kinase
METTL7A methyltransferase like 7A
MFGE8 milk fat globule-EGF factor 8 protein
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NDRG1 N-myc downstream regulated 1
NFIL3 nuclear factor, interleukin 3 regulated
NPDC1 neural proliferation, differentiation and control, 1
NT5DC2 5'-nucleotidase domain containing 2
OBSL1 obscurin-like 1
OPN3 opsin 3
PAN2 PAN2 poly(A) specific ribonuclease subunit
PEG10 paternally expressed 10
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLXNB2 plexin B2
POU2AF1 POU class 2 associating factor 1
PPDPF pancreatic progenitor cell differentiation and proliferation factor
PPL periplakin
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRAME preferentially expressed antigen in melanoma
PROM1 prominin 1
PRSS21 protease, serine, 21 (testisin)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBPMS RNA binding protein with multiple splicing
S100A10 S100 calcium binding protein A10
S100A4 S100 calcium binding protein A4
S100A9 S100 calcium binding protein A9
SCGB2A2 secretoglobin, family 2A, member 2
SFRP1 secreted frizzled-related protein 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLPI secretory leukocyte peptidase inhibitor
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STK39 serine threonine kinase 39
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TCL1A T-cell leukemia/lymphoma 1A
TFPI2 tissue factor pathway inhibitor 2
TGM2 transglutaminase 2
TMX4 thioredoxin-related transmembrane protein 4
TRIM29 tripartite motif containing 29
TSC22D1 TSC22 domain family, member 1
TXNIP thioredoxin interacting protein
UCKL1 uridine-cytidine kinase 1-like 1
VCAN versican
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ADORA2B adenosine A2b receptor
ALCAM activated leukocyte cell adhesion molecule
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
BAD BCL2-associated agonist of cell death
BCL2A1 BCL2-related protein A1
C8ORF4 chromosome 8 open reading frame 4
CASP7 caspase 7, apoptosis-related cysteine peptidase
CD69 CD69 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CELF2 CUGBP, Elav-like family member 2
CLCA1 chloride channel accessory 1
CLEC2B C-type lectin domain family 2, member B
CTGF connective tissue growth factor
CTSK cathepsin K
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
DACH1 dachshund family transcription factor 1
DAPK1 death-associated protein kinase 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EGR3 early growth response 3
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM134B family with sequence similarity 134, member B
FCGBP Fc fragment of IgG binding protein
FERMT1 fermitin family member 1
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GAS2 growth arrest-specific 2
GFOD1 glucose-fructose oxidoreductase domain containing 1
GOLGA8H golgin A8 family, member H
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HOMER1 homer scaffolding protein 1
HOPX HOP homeobox
IFI16 interferon, gamma-inducible protein 16
IFI27 interferon, alpha-inducible protein 27
IFI44 interferon-induced protein 44
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IL13RA2 interleukin 13 receptor, alpha 2
ISG15 ISG15 ubiquitin-like modifier
KDM5D lysine (K)-specific demethylase 5D
LAMP5 lysosomal-associated membrane protein family, member 5
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LHX2 LIM homeobox 2
MCAM melanoma cell adhesion molecule
MFAP2 microfibrillar-associated protein 2
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
MOXD1 monooxygenase, DBH-like 1
MX1 MX dynamin-like GTPase 1
MYB v-myb avian myeloblastosis viral oncogene homolog
NEBL nebulette
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
ODAM odontogenic, ameloblast asssociated
PCM1 pericentriolar material 1
PRR7 proline rich 7 (synaptic)
PSPH phosphoserine phosphatase
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RBP1 retinol binding protein 1, cellular
RGS1 regulator of G-protein signaling 1
RGS10 regulator of G-protein signaling 10
RGS4 regulator of G-protein signaling 4
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPS4Y1 ribosomal protein S4, Y-linked 1
RSAD2 radical S-adenosyl methionine domain containing 2
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SFTPA2 surfactant protein A2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPON1 spondin 1, extracellular matrix protein
SPP1 secreted phosphoprotein 1
SST somatostatin
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STEAP1 six transmembrane epithelial antigen of the prostate 1
STK10 serine/threonine kinase 10
TACC1 transforming, acidic coiled-coil containing protein 1
TESC tescalcin
TFF3 trefoil factor 3 (intestinal)
THBS1 thrombospondin 1
TSPAN8 tetraspanin 8
UFM1 ubiquitin-fold modifier 1
WSB1 WD repeat and SOCS box containing 1