BRD-K06569345_HG-5-88-01_HT29_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

126 genes differentially expressed following the BRD-K06569345_HG-5-88-01_HT29_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD6 abhydrolase domain containing 6
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
AKAP8 A kinase (PRKA) anchor protein 8
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
BEX1 brain expressed, X-linked 1
BLMH bleomycin hydrolase
C1S complement component 1, s subcomponent
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL20 chemokine (C-C motif) ligand 20
CCL5 chemokine (C-C motif) ligand 5
CCND2 cyclin D2
CD3D CD3d molecule, delta (CD3-TCR complex)
CDC42 cell division cycle 42
CHMP4A charged multivesicular body protein 4A
COCH cochlin
COL1A1 collagen, type I, alpha 1
COL6A1 collagen, type VI, alpha 1
COL9A3 collagen, type IX, alpha 3
CPD carboxypeptidase D
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTSB cathepsin B
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DEFB1 defensin, beta 1
DMBT1 deleted in malignant brain tumors 1
EIF4B eukaryotic translation initiation factor 4B
ENO2 enolase 2 (gamma, neuronal)
ETV1 ets variant 1
FCGBP Fc fragment of IgG binding protein
FGG fibrinogen gamma chain
FUCA1 fucosidase, alpha-L- 1, tissue
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GLUL glutamate-ammonia ligase
GPRC5B G protein-coupled receptor, class C, group 5, member B
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
GZMK granzyme K (granzyme 3; tryptase II)
HCAR3 hydroxycarboxylic acid receptor 3
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HP haptoglobin
IL17RB interleukin 17 receptor B
IL1R2 interleukin 1 receptor, type II
IL2RG interleukin 2 receptor, gamma
IL6ST interleukin 6 signal transducer
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIAA1598
KIF1B kinesin family member 1B
KLF9 Kruppel-like factor 9
KRT10 keratin 10, type I
LCN2 lipocalin 2
LEPROTL1 leptin receptor overlapping transcript-like 1
LRRC16A leucine rich repeat containing 16A
LTF lactotransferrin
LY6D lymphocyte antigen 6 complex, locus D
LYN LYN proto-oncogene, Src family tyrosine kinase
MARCKS myristoylated alanine-rich protein kinase C substrate
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
METRN meteorin, glial cell differentiation regulator
MMP9 matrix metallopeptidase 9
MUC5B mucin 5B, oligomeric mucus/gel-forming
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NTS neurotensin
OXSR1 oxidative stress responsive 1
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PDZK1IP1 PDZK1 interacting protein 1
PI3 peptidase inhibitor 3, skin-derived
PRUNE prune exopolyphosphatase
PTGES prostaglandin E synthase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RELN reelin
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
S100A7 S100 calcium binding protein A7
SCYL3 SCY1-like 3 (S. cerevisiae)
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
STARD13 StAR-related lipid transfer (START) domain containing 13
STXBP1 syntaxin binding protein 1
SYNGR3 synaptogyrin 3
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TNIK TRAF2 and NCK interacting kinase
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TXNIP thioredoxin interacting protein
UGCG UDP-glucose ceramide glucosyltransferase

decreased expression

Symbol Name
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ACKR3 atypical chemokine receptor 3
AIM1 absent in melanoma 1
ATG3 autophagy related 3
BPGM 2,3-bisphosphoglycerate mutase
C1ORF116 chromosome 1 open reading frame 116
CDC20 cell division cycle 20
CLDN3 claudin 3
CX3CR1 chemokine (C-X3-C motif) receptor 1
EAF2 ELL associated factor 2
EIF5A eukaryotic translation initiation factor 5A
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ELOVL1 ELOVL fatty acid elongase 1
FABP4 fatty acid binding protein 4, adipocyte
FXYD3 FXYD domain containing ion transport regulator 3
GSN gelsolin
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IER5 immediate early response 5
IGFBP5 insulin-like growth factor binding protein 5
LMO3 LIM domain only 3 (rhombotin-like 2)
MEF2C myocyte enhancer factor 2C
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form)
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PSCA prostate stem cell antigen
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTHLH parathyroid hormone-like hormone
SNX7 sorting nexin 7
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
TP53I3 tumor protein p53 inducible protein 3
VCAN versican