BRD-K06569345_HG-5-88-01_HME1_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

121 genes differentially expressed following the BRD-K06569345_HG-5-88-01_HME1_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACTA2 actin, alpha 2, smooth muscle, aorta
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA1 annexin A1
ATF3 activating transcription factor 3
BCL6 B-cell CLL/lymphoma 6
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CELF2 CUGBP, Elav-like family member 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYB561 cytochrome b561
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAPK1 death-associated protein kinase 1
DDIT3 DNA-damage-inducible transcript 3
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR2 early growth response 2
EREG epiregulin
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GBP2 guanylate binding protein 2, interferon-inducible
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GPX3 glutathione peroxidase 3
HES1 hes family bHLH transcription factor 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFI44L interferon-induced protein 44-like
IFITM1 interferon induced transmembrane protein 1
IRS2 insulin receptor substrate 2
ISG15 ISG15 ubiquitin-like modifier
JUNB jun B proto-oncogene
KIF14 kinesin family member 14
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
LMO4 LIM domain only 4
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP3K8 mitogen-activated protein kinase kinase kinase 8
METTL7A methyltransferase like 7A
MGP matrix Gla protein
NAMPT nicotinamide phosphoribosyltransferase
NDRG2 NDRG family member 2
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
PDLIM5 PDZ and LIM domain 5
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SPARCL1 SPARC-like 1 (hevin)
SPP1 secreted phosphoprotein 1
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
TMEM135 transmembrane protein 135
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TREM1 triggering receptor expressed on myeloid cells 1
TSC22D3 TSC22 domain family, member 3
VCAM1 vascular cell adhesion molecule 1
WT1 Wilms tumor 1
ZFP36 ZFP36 ring finger protein
ZMAT3 zinc finger, matrin-type 3
ZNF277 zinc finger protein 277

decreased expression

Symbol Name
ALB albumin
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CCND1 cyclin D1
CCNE2 cyclin E2
CD40 CD40 molecule, TNF receptor superfamily member 5
CDC25A cell division cycle 25A
CKAP4 cytoskeleton-associated protein 4
CRIP1 cysteine-rich protein 1 (intestinal)
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL9 chemokine (C-X-C motif) ligand 9
DCN decorin
DKK3 dickkopf WNT signaling pathway inhibitor 3
EIF5A eukaryotic translation initiation factor 5A
FASTKD5 FAST kinase domains 5
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
GPRC5A G protein-coupled receptor, class C, group 5, member A
HAT1 histone acetyltransferase 1
HMG20B high mobility group 20B
HMGA2 high mobility group AT-hook 2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA8 heat shock 70kDa protein 8
ITGA6 integrin, alpha 6
KIF1BP KIF1 binding protein
LAMP3 lysosomal-associated membrane protein 3
MAGEA3 melanoma antigen family A3
MAT2A methionine adenosyltransferase II, alpha
NEBL nebulette
NID1 nidogen 1
OLFM4 olfactomedin 4
P3H2 prolyl 3-hydroxylase 2
PDGFC platelet derived growth factor C
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PLAT plasminogen activator, tissue
PPP1R3C protein phosphatase 1, regulatory subunit 3C
RPS11 ribosomal protein S11
SCUBE2 signal peptide, CUB domain, EGF-like 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
TACSTD2 tumor-associated calcium signal transducer 2
TGM2 transglutaminase 2
WFDC1 WAP four-disulfide core domain 1