BRD-K06543683_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

256 genes differentially expressed following the BRD-K06543683_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ADD3 adducin 3 (gamma)
AEBP1 AE binding protein 1
ANGPTL2 angiopoietin-like 2
ANXA1 annexin A1
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
ARL4C ADP-ribosylation factor-like 4C
ASPN asporin
BEX1 brain expressed, X-linked 1
BTG3 BTG family, member 3
CADM1 cell adhesion molecule 1
CALD1 caldesmon 1
CD24 CD24 molecule
CD44 CD44 molecule (Indian blood group)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC2B C-type lectin domain family 2, member B
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A2 collagen, type VI, alpha 2
COL8A2 collagen, type VIII, alpha 2
COLEC12 collectin sub-family member 12
CPE carboxypeptidase E
CTGF connective tissue growth factor
CTSK cathepsin K
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
CYR61 cysteine-rich, angiogenic inducer, 61
DEFA4 defensin, alpha 4, corticostatin
DESI2 desumoylating isopeptidase 2
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPP4 dipeptidyl-peptidase 4
DPYSL3 dihydropyrimidinase-like 3
DUSP6 dual specificity phosphatase 6
ECM1 extracellular matrix protein 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF5A eukaryotic translation initiation factor 5A
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FABP4 fatty acid binding protein 4, adipocyte
FGL2 fibrinogen-like 2
FST follistatin
GBP1 guanylate binding protein 1, interferon-inducible
GJA1 gap junction protein, alpha 1, 43kDa
GPNMB glycoprotein (transmembrane) nmb
GPX1 glutathione peroxidase 1
GSN gelsolin
GUSBP3 glucuronidase, beta pseudogene 3
HIST1H1C histone cluster 1, H1c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HTRA1 HtrA serine peptidase 1
IFI44 interferon-induced protein 44
IFITM1 interferon induced transmembrane protein 1
IGFBP7 insulin-like growth factor binding protein 7
INSM1 insulinoma-associated 1
ISG15 ISG15 ubiquitin-like modifier
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
LCK LCK proto-oncogene, Src family tyrosine kinase
LOC100272216 uncharacterized LOC100272216
LRRC15 leucine rich repeat containing 15
LUM lumican
LY96 lymphocyte antigen 96
LYN LYN proto-oncogene, Src family tyrosine kinase
MDFIC MyoD family inhibitor domain containing
MFAP2 microfibrillar-associated protein 2
MFAP5 microfibrillar associated protein 5
MMP11 matrix metallopeptidase 11
MMP9 matrix metallopeptidase 9
MSN moesin
MX1 MX dynamin-like GTPase 1
MYL9 myosin, light chain 9, regulatory
NCF1C neutrophil cytosolic factor 1C pseudogene
NT5E 5'-nucleotidase, ecto (CD73)
OLFM4 olfactomedin 4
ORM1 orosomucoid 1
PDGFD platelet derived growth factor D
PLS3 plastin 3
PLVAP plasmalemma vesicle associated protein
PNMA2 paraneoplastic Ma antigen 2
PTPRC protein tyrosine phosphatase, receptor type, C
PTRF polymerase I and transcript release factor
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RTN1 reticulon 1
SCG5 secretogranin V
SCGB2A1 secretoglobin, family 2A, member 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFRP4 secreted frizzled-related protein 4
SHOX2 short stature homeobox 2
SMYD3 SET and MYND domain containing 3
SNAI2 snail family zinc finger 2
SNX7 sorting nexin 7
SPAG16 sperm associated antigen 16
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SST somatostatin
STC1 stanniocalcin 1
SULF1 sulfatase 1
TFPI2 tissue factor pathway inhibitor 2
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM45A transmembrane protein 45A
TRDV3 T cell receptor delta variable 3
TSPAN12 tetraspanin 12
TUSC3 tumor suppressor candidate 3
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ADNP activity-dependent neuroprotector homeobox
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AGR2 anterior gradient 2
AHNAK AHNAK nucleoprotein
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ASF1A anti-silencing function 1A histone chaperone
ATMIN ATM interactor
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
B3GNT1
BAG3 BCL2-associated athanogene 3
BAG5 BCL2-associated athanogene 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C14ORF169 chromosome 14 open reading frame 169
CA12 carbonic anhydrase XII
CANT1 calcium activated nucleotidase 1
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCNA2 cyclin A2
CCNB2 cyclin B2
CD58 CD58 molecule
CDC123 cell division cycle 123
CDC20 cell division cycle 20
CDCA4 cell division cycle associated 4
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CENPA centromere protein A
CHMP7 charged multivesicular body protein 7
CHPT1 choline phosphotransferase 1
CKS2 CDC28 protein kinase regulatory subunit 2
CRNKL1 crooked neck pre-mRNA splicing factor 1
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
CTR9 CTR9, Paf1/RNA polymerase II complex component
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DBF4 DBF4 zinc finger
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLD dihydrolipoamide dehydrogenase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EED embryonic ectoderm development
EIF4A3 eukaryotic translation initiation factor 4A3
FEM1B fem-1 homolog b (C. elegans)
FEN1 flap structure-specific endonuclease 1
FOXO3 forkhead box O3
GABPB1 GA binding protein transcription factor, beta subunit 1
GATA3 GATA binding protein 3
GDI2 GDP dissociation inhibitor 2
GEMIN4 gem (nuclear organelle) associated protein 4
GLOD4 glyoxalase domain containing 4
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRWD1 glutamate-rich WD repeat containing 1
H2AFX H2A histone family, member X
HN1 hematological and neurological expressed 1
HOXC6 homeobox C6
HSPA14 heat shock 70kDa protein 14
HSPA8 heat shock 70kDa protein 8
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IER3 immediate early response 3
IGF1R insulin-like growth factor 1 receptor
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
INTS5 integrator complex subunit 5
JADE2 jade family PHD finger 2
KIF20A kinesin family member 20A
KLF4 Kruppel-like factor 4 (gut)
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KYNU kynureninase
MACF1 microtubule-actin crosslinking factor 1
MCM10 minichromosome maintenance complex component 10
MCOLN1 mucolipin 1
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MKI67 marker of proliferation Ki-67
MRFAP1L1 Morf4 family associated protein 1-like 1
MRPS2 mitochondrial ribosomal protein S2
MSH6 mutS homolog 6
MTPAP mitochondrial poly(A) polymerase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NET1 neuroepithelial cell transforming 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NMD3 NMD3 ribosome export adaptor
NOP56 NOP56 ribonucleoprotein
NOTCH2 notch 2
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
NUP50 nucleoporin 50kDa
OPN3 opsin 3
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PARP2 poly (ADP-ribose) polymerase 2
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PCNA proliferating cell nuclear antigen
PDS5A PDS5 cohesin associated factor A
PLK1 polo-like kinase 1
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
PRC1 protein regulator of cytokinesis 1
PRPF4 pre-mRNA processing factor 4
PRPF4B pre-mRNA processing factor 4B
PRSS23 protease, serine, 23
RAB14 RAB14, member RAS oncogene family
RACGAP1 Rac GTPase activating protein 1
RANBP2 RAN binding protein 2
RBM15 RNA binding motif protein 15
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RNMT RNA (guanine-7-) methyltransferase
RPP38 ribonuclease P/MRP 38kDa subunit
SCAF8 SR-related CTD-associated factor 8
SCEL sciellin
SETX senataxin
SFN stratifin
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SOX4 SRY (sex determining region Y)-box 4
SPTBN1 spectrin, beta, non-erythrocytic 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TBX2 T-box 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TDP1 tyrosyl-DNA phosphodiesterase 1
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFF1 trefoil factor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THUMPD1 THUMP domain containing 1
TM2D3 TM2 domain containing 3
TMEM100 transmembrane protein 100
TMEM251 transmembrane protein 251
TMX4 thioredoxin-related transmembrane protein 4
TNC tenascin C
TOB1 transducer of ERBB2, 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TRAPPC4 trafficking protein particle complex 4
TSKU tsukushi, small leucine rich proteoglycan
TSPYL1 TSPY-like 1
TSPYL5 TSPY-like 5
UBE2C ubiquitin-conjugating enzyme E2C
UBE4A ubiquitination factor E4A
UTP11L UTP11-like, U3 small nucleolar ribonucleoprotein (yeast)
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
YME1L1 YME1-like 1 ATPase
ZNF185 zinc finger protein 185 (LIM domain)