BRD-K06543683_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

187 genes differentially expressed following the BRD-K06543683_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANXA1 annexin A1
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
ATF3 activating transcription factor 3
BEX4 brain expressed, X-linked 4
CETN2 centrin, EF-hand protein, 2
CLIC5 chloride intracellular channel 5
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10
EGR1 early growth response 1
ENO1 enolase 1, (alpha)
FGG fibrinogen gamma chain
FKBP1B FK506 binding protein 1B, 12.6 kDa
GPM6A glycoprotein M6A
GULP1 GULP, engulfment adaptor PTB domain containing 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ISYNA1 inositol-3-phosphate synthase 1
KIAA0226L KIAA0226-like
L1CAM L1 cell adhesion molecule
LAPTM4B lysosomal protein transmembrane 4 beta
LTA4H leukotriene A4 hydrolase
MME membrane metallo-endopeptidase
MOXD1 monooxygenase, DBH-like 1
NREP neuronal regeneration related protein
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
PRKCI protein kinase C, iota
PTGDS prostaglandin D2 synthase 21kDa (brain)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RNF5 ring finger protein 5, E3 ubiquitin protein ligase
RPS4Y1 ribosomal protein S4, Y-linked 1
SDC2 syndecan 2
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
TMSB15A thymosin beta 15a
TNNC1 troponin C type 1 (slow)
TPD52 tumor protein D52
TUBA1A tubulin, alpha 1a
TUSC3 tumor suppressor candidate 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
ZNF532 zinc finger protein 532
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ACBD3 acyl-CoA binding domain containing 3
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADM adrenomedullin
ADNP activity-dependent neuroprotector homeobox
AHR aryl hydrocarbon receptor
ANO1 anoctamin 1, calcium activated chloride channel
ARF6 ADP-ribosylation factor 6
ARPC5L actin related protein 2/3 complex, subunit 5-like
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BTG1 B-cell translocation gene 1, anti-proliferative
C14ORF169 chromosome 14 open reading frame 169
C15ORF39 chromosome 15 open reading frame 39
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CANT1 calcium activated nucleotidase 1
CCNA2 cyclin A2
CCNF cyclin F
CD3EAP CD3e molecule, epsilon associated protein
CD58 CD58 molecule
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDCA8 cell division cycle associated 8
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDR2 cerebellar degeneration-related protein 2, 62kDa
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CHERP calcium homeostasis endoplasmic reticulum protein
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CSK c-src tyrosine kinase
CST3 cystatin C
CX3CR1 chemokine (C-X3-C motif) receptor 1
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP14 dual specificity phosphatase 14
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EED embryonic ectoderm development
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ERBB2 erb-b2 receptor tyrosine kinase 2
EXOSC4 exosome component 4
FADD Fas (TNFRSF6)-associated via death domain
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
FZD7 frizzled class receptor 7
GABPB1 GA binding protein transcription factor, beta subunit 1
GCH1 GTP cyclohydrolase 1
GEMIN4 gem (nuclear organelle) associated protein 4
GRWD1 glutamate-rich WD repeat containing 1
H2AFX H2A histone family, member X
HMGB2 high mobility group box 2
HMOX1 heme oxygenase 1
HOXA5 homeobox A5
HSPA8 heat shock 70kDa protein 8
IER2 immediate early response 2
IER5 immediate early response 5
IGFBP4 insulin-like growth factor binding protein 4
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
INPP1 inositol polyphosphate-1-phosphatase
INTS5 integrator complex subunit 5
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JADE2 jade family PHD finger 2
JMJD6 jumonji domain containing 6
KANK1 KN motif and ankyrin repeat domains 1
KEAP1 kelch-like ECH-associated protein 1
KIF2C kinesin family member 2C
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LAT2 linker for activation of T cells family, member 2
LMO2 LIM domain only 2 (rhombotin-like 1)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MCL1 myeloid cell leukemia 1
MCM10 minichromosome maintenance complex component 10
MED17 mediator complex subunit 17
MEPCE methylphosphate capping enzyme
MFSD5 major facilitator superfamily domain containing 5
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MKI67 marker of proliferation Ki-67
MRPS30 mitochondrial ribosomal protein S30
MSH6 mutS homolog 6
MYC v-myc avian myelocytomatosis viral oncogene homolog
NET1 neuroepithelial cell transforming 1
NKX3-1 NK3 homeobox 1
NOL11 nucleolar protein 11
NOP56 NOP56 ribonucleoprotein
NUP62 nucleoporin 62kDa
PDE4B phosphodiesterase 4B, cAMP-specific
PDLIM5 PDZ and LIM domain 5
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
PLK2 polo-like kinase 2
PPIF peptidylprolyl isomerase F
PPP1R10 protein phosphatase 1, regulatory subunit 10
PRC1 protein regulator of cytokinesis 1
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PTRH2 peptidyl-tRNA hydrolase 2
RAB14 RAB14, member RAS oncogene family
RAD9A RAD9 homolog A (S. pombe)
RAP2B RAP2B, member of RAS oncogene family
RBM14 RNA binding motif protein 14
RGS2 regulator of G-protein signaling 2
RIN2 Ras and Rab interactor 2
RNF139 ring finger protein 139
RNF19B ring finger protein 19B
RNMTL1 RNA methyltransferase like 1
RPP38 ribonuclease P/MRP 38kDa subunit
RUNX3 runt-related transcription factor 3
SCAF8 SR-related CTD-associated factor 8
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
SLC38A2 solute carrier family 38, member 2
SNRPE small nuclear ribonucleoprotein polypeptide E
SOX4 SRY (sex determining region Y)-box 4
SRGN serglycin
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFF1 trefoil factor 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TPM4 tropomyosin 4
TSC22D2 TSC22 domain family, member 2
TSKU tsukushi, small leucine rich proteoglycan
TXLNA taxilin alpha
UBAP2L ubiquitin associated protein 2-like
WDR82 WD repeat domain 82
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZC3H4 zinc finger CCCH-type containing 4
ZNF22 zinc finger protein 22