BRD-K06543683_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

260 genes differentially expressed following the BRD-K06543683_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ACPP acid phosphatase, prostate
ADD3 adducin 3 (gamma)
ADGRA2 adhesion G protein-coupled receptor A2
AEBP1 AE binding protein 1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AREG amphiregulin
ASPN asporin
BLNK B-cell linker
BTG2 BTG family, member 2
CA1 carbonic anhydrase I
CALD1 caldesmon 1
CD200 CD200 molecule
CD24 CD24 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CKB creatine kinase, brain
CLIC5 chloride intracellular channel 5
COL18A1 collagen, type XVIII, alpha 1
CRIP2 cysteine-rich protein 2
CTSZ cathepsin Z
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPYSL3 dihydropyrimidinase-like 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFHD1 EF-hand domain family, member D1
EGR1 early growth response 1
F11R F11 receptor
FABP1 fatty acid binding protein 1, liver
FBLN1 fibulin 1
FGG fibrinogen gamma chain
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXF1 forkhead box F1
G0S2 G0/G1 switch 2
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GULP1 GULP, engulfment adaptor PTB domain containing 1
IFT57 intraflagellar transport 57
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IGHM immunoglobulin heavy constant mu
IL1R1 interleukin 1 receptor, type I
INA internexin neuronal intermediate filament protein, alpha
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KRT19 keratin 19, type I
KRT8 keratin 8, type II
MBOAT2 membrane bound O-acyltransferase domain containing 2
MS4A12 membrane-spanning 4-domains, subfamily A, member 12
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR5A2 nuclear receptor subfamily 5, group A, member 2
OLFM4 olfactomedin 4
ORM1 orosomucoid 1
PBX3 pre-B-cell leukemia homeobox 3
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCSK6 proprotein convertase subtilisin/kexin type 6
PDE9A phosphodiesterase 9A
PDIA3 protein disulfide isomerase family A, member 3
PKP2 plakophilin 2
PLVAP plasmalemma vesicle associated protein
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PROSC proline synthetase co-transcribed homolog (bacterial)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP1 retinol binding protein 1, cellular
RGS5 regulator of G-protein signaling 5
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SEPT2 septin 2
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SQRDL sulfide quinone reductase-like (yeast)
SULF1 sulfatase 1
SUSD4 sushi domain containing 4
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TSPAN7 tetraspanin 7
TTC39A tetratricopeptide repeat domain 39A
VTCN1 V-set domain containing T cell activation inhibitor 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACBD3 acyl-CoA binding domain containing 3
ADNP activity-dependent neuroprotector homeobox
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ADRB2 adrenoceptor beta 2, surface
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMD1 adenosylmethionine decarboxylase 1
ARF6 ADP-ribosylation factor 6
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARL4A ADP-ribosylation factor-like 4A
ARPC5L actin related protein 2/3 complex, subunit 5-like
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BASP1 brain abundant, membrane attached signal protein 1
C14ORF169 chromosome 14 open reading frame 169
CCNA2 cyclin A2
CCNF cyclin F
CD3EAP CD3e molecule, epsilon associated protein
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CHERP calcium homeostasis endoplasmic reticulum protein
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DFNA5 deafness, autosomal dominant 5
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP10 dual specificity phosphatase 10
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
EFHD2 EF-hand domain family, member D2
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ETV5 ets variant 5
EXOSC4 exosome component 4
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FADD Fas (TNFRSF6)-associated via death domain
FAM46A family with sequence similarity 46, member A
FASTKD5 FAST kinase domains 5
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
FOXJ3 forkhead box J3
GABPB1 GA binding protein transcription factor, beta subunit 1
GEMIN4 gem (nuclear organelle) associated protein 4
GOSR1 golgi SNAP receptor complex member 1
GRWD1 glutamate-rich WD repeat containing 1
H2AFX H2A histone family, member X
HMG20B high mobility group 20B
HMOX1 heme oxygenase 1
HOMER1 homer scaffolding protein 1
HOXA10 homeobox A10
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
IRS2 insulin receptor substrate 2
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JADE1 jade family PHD finger 1
JADE2 jade family PHD finger 2
JMJD6 jumonji domain containing 6
KANK1 KN motif and ankyrin repeat domains 1
KAT6A K(lysine) acetyltransferase 6A
KDM2A lysine (K)-specific demethylase 2A
KEAP1 kelch-like ECH-associated protein 1
KRT14 keratin 14, type I
KRT7 keratin 7, type II
KYNU kynureninase
LAT2 linker for activation of T cells family, member 2
LDLR low density lipoprotein receptor
LIMCH1 LIM and calponin homology domains 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAK16 MAK16 homolog (S. cerevisiae)
MAPK6 mitogen-activated protein kinase 6
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MAT2A methionine adenosyltransferase II, alpha
MFSD5 major facilitator superfamily domain containing 5
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MRPS30 mitochondrial ribosomal protein S30
NET1 neuroepithelial cell transforming 1
NFIB nuclear factor I/B
NKX3-1 NK3 homeobox 1
NNMT nicotinamide N-methyltransferase
NOP16 NOP16 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NOTCH2NL notch 2 N-terminal like
NRN1 neuritin 1
NUP62 nucleoporin 62kDa
NXT1 nuclear transport factor 2-like export factor 1
PDGFA platelet-derived growth factor alpha polypeptide
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLK1 polo-like kinase 1
PLK2 polo-like kinase 2
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PPIF peptidylprolyl isomerase F
PRKD3 protein kinase D3
PTRH2 peptidyl-tRNA hydrolase 2
PTX3 pentraxin 3, long
PXDC1 PX domain containing 1
RAE1 ribonucleic acid export 1
RAP2B RAP2B, member of RAS oncogene family
RBM12 RNA binding motif protein 12
RBM14 RNA binding motif protein 14
RBM15 RNA binding motif protein 15
RGS2 regulator of G-protein signaling 2
RIN2 Ras and Rab interactor 2
RNF19B ring finger protein 19B
RNF4 ring finger protein 4
RPL36AL ribosomal protein L36a-like
RPS11 ribosomal protein S11
RRAGA Ras-related GTP binding A
RSL1D1 ribosomal L1 domain containing 1
RUNX3 runt-related transcription factor 3
SACS sacsin molecular chaperone
SAP30 Sin3A-associated protein, 30kDa
SCAF8 SR-related CTD-associated factor 8
SCAND1 SCAN domain containing 1
SEPHS2 selenophosphate synthetase 2
SERBP1 SERPINE1 mRNA binding protein 1
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFPQ splicing factor proline/glutamine-rich
SGK1 serum/glucocorticoid regulated kinase 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC25A44 solute carrier family 25, member 44
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SMAD3 SMAD family member 3
SMAD7 SMAD family member 7
SOX9 SRY (sex determining region Y)-box 9
SPRY2 sprouty homolog 2 (Drosophila)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TBC1D4 TBC1 domain family, member 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TEFM transcription elongation factor, mitochondrial
TEX10 testis expressed 10
TFB2M transcription factor B2, mitochondrial
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TMEM11 transmembrane protein 11
TNC tenascin C
TNPO1 transportin 1
TOB2 transducer of ERBB2, 2
TP53BP2 tumor protein p53 binding protein 2
TSC22D2 TSC22 domain family, member 2
TUBA4A tubulin, alpha 4a
TUBB4B tubulin, beta 4B class IVb
TXLNA taxilin alpha
TXNRD1 thioredoxin reductase 1
UBAP2L ubiquitin associated protein 2-like
UBE2S ubiquitin-conjugating enzyme E2S
UGCG UDP-glucose ceramide glucosyltransferase
UMPS uridine monophosphate synthetase
USP22 ubiquitin specific peptidase 22
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
WDR6 WD repeat domain 6
WDR82 WD repeat domain 82
WEE1 WEE1 G2 checkpoint kinase
WIPF2 WAS/WASL interacting protein family, member 2
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2
ZC3H4 zinc finger CCCH-type containing 4
ZNF146 zinc finger protein 146