BRD-K06426971_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

89 genes differentially expressed following the BRD-K06426971_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1
ADM adrenomedullin
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ANPEP alanyl (membrane) aminopeptidase
APOA1 apolipoprotein A-I
ATF3 activating transcription factor 3
BEX4 brain expressed, X-linked 4
CASP1 caspase 1, apoptosis-related cysteine peptidase
CD44 CD44 molecule (Indian blood group)
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDK2 cyclin-dependent kinase 2
CYR61 cysteine-rich, angiogenic inducer, 61
DKK3 dickkopf WNT signaling pathway inhibitor 3
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EGR2 early growth response 2
EIF1 eukaryotic translation initiation factor 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GMPR guanosine monophosphate reductase
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
JUN jun proto-oncogene
KLF6 Kruppel-like factor 6
LPAR6 lysophosphatidic acid receptor 6
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCL1 myeloid cell leukemia 1
MEIS2 Meis homeobox 2
NDRG1 N-myc downstream regulated 1
NEFH neurofilament, heavy polypeptide
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NT5E 5'-nucleotidase, ecto (CD73)
P3H2 prolyl 3-hydroxylase 2
PELI1 pellino E3 ubiquitin protein ligase 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PYCARD PYD and CARD domain containing
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGS2 regulator of G-protein signaling 2
RND3 Rho family GTPase 3
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RTN2 reticulon 2
SCGB1D2 secretoglobin, family 1D, member 2
SCUBE2 signal peptide, CUB domain, EGF-like 2
SFRP1 secreted frizzled-related protein 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SOX17 SRY (sex determining region Y)-box 17
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIB1 tribbles pseudokinase 1
VTCN1 V-set domain containing T cell activation inhibitor 1
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AK1 adenylate kinase 1
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
BMI1 BMI1 proto-oncogene, polycomb ring finger
COL5A1 collagen, type V, alpha 1
CXCL14 chemokine (C-X-C motif) ligand 14
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DIO2 deiodinase, iodothyronine, type II
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FOLR1 folate receptor 1 (adult)
IL6ST interleukin 6 signal transducer
LPL lipoprotein lipase
LTF lactotransferrin
MGP matrix Gla protein
PLAGL1 pleiomorphic adenoma gene-like 1
PRDX1 peroxiredoxin 1
RCN2 reticulocalbin 2, EF-hand calcium binding domain
S100P S100 calcium binding protein P
SCAMP1 secretory carrier membrane protein 1
SET SET nuclear proto-oncogene
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TRAK2 trafficking protein, kinesin binding 2