BRD-K06405410_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

117 genes differentially expressed following the BRD-K06405410_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACADVL acyl-CoA dehydrogenase, very long chain
ADGRG6 adhesion G protein-coupled receptor G6
AHNAK AHNAK nucleoprotein
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDOC aldolase C, fructose-bisphosphate
ARG2 arginase 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BMP6 bone morphogenetic protein 6
BTG1 B-cell translocation gene 1, anti-proliferative
CCNG2 cyclin G2
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COCH cochlin
CRIP1 cysteine-rich protein 1 (intestinal)
CSTA cystatin A (stefin A)
DDIT4 DNA-damage-inducible transcript 4
DEPTOR DEP domain containing MTOR-interacting protein
DUSP1 dual specificity phosphatase 1
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EPN2 epsin 2
FA2H fatty acid 2-hydroxylase
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FAM129A family with sequence similarity 129, member A
FHL1 four and a half LIM domains 1
FOLR1 folate receptor 1 (adult)
FTH1 ferritin, heavy polypeptide 1
GARS glycyl-tRNA synthetase
GPC3 glypican 3
H1F0 H1 histone family, member 0
H1FX H1 histone family, member X
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
LYZ lysozyme
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP1B microtubule-associated protein 1B
MAP7 microtubule-associated protein 7
MMD monocyte to macrophage differentiation-associated
MSMO1 methylsterol monooxygenase 1
MT1M metallothionein 1M
MTSS1 metastasis suppressor 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDZK1IP1 PDZK1 interacting protein 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLIN2 perilipin 2
PLK2 polo-like kinase 2
PSPH phosphoserine phosphatase
QPCT glutaminyl-peptide cyclotransferase
RGS5 regulator of G-protein signaling 5
RHOB ras homolog family member B
RND3 Rho family GTPase 3
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SIK1 salt-inducible kinase 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SORBS1 sorbin and SH3 domain containing 1
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SQLE squalene epoxidase
SRC SRC proto-oncogene, non-receptor tyrosine kinase
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
SYNGR1 synaptogyrin 1
TBX3 T-box 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TRIB3 tribbles pseudokinase 3
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
TYRP1 tyrosinase-related protein 1
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
WDTC1 WD and tetratricopeptide repeats 1
YBX3 Y box binding protein 3

decreased expression

Symbol Name
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ATF5 activating transcription factor 5
CCL4 chemokine (C-C motif) ligand 4
CCND1 cyclin D1
CD164 CD164 molecule, sialomucin
CP ceruloplasmin (ferroxidase)
DMD dystrophin
EGR2 early growth response 2
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
GIMAP4 GTPase, IMAP family member 4
GLUL glutamate-ammonia ligase
GPRC5A G protein-coupled receptor, class C, group 5, member A
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HOPX HOP homeobox
IGFBP7 insulin-like growth factor binding protein 7
IQGAP1 IQ motif containing GTPase activating protein 1
KCTD12 potassium channel tetramerization domain containing 12
KRT17 keratin 17, type I
KRT7 keratin 7, type II
LMO4 LIM domain only 4
LTF lactotransferrin
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MECOM MDS1 and EVI1 complex locus
MMP9 matrix metallopeptidase 9
MYO6 myosin VI
NRIP1 nuclear receptor interacting protein 1
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
POSTN periostin, osteoblast specific factor
PRKCD protein kinase C, delta
RPS26 ribosomal protein S26
SEPP1 selenoprotein P, plasma, 1
SLPI secretory leukocyte peptidase inhibitor
TACSTD2 tumor-associated calcium signal transducer 2
TLR4 toll-like receptor 4
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOR1A torsin family 1, member A (torsin A)
UBE3C ubiquitin protein ligase E3C