BRD-K06405410_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

110 genes differentially expressed following the BRD-K06405410_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANPEP alanyl (membrane) aminopeptidase
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARL4C ADP-ribosylation factor-like 4C
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
BEX4 brain expressed, X-linked 4
CBS cystathionine-beta-synthase
CCND2 cyclin D2
CCNG2 cyclin G2
CD52 CD52 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHD7 chromodomain helicase DNA binding protein 7
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN3 claudin 3
CLDN7 claudin 7
CLIC5 chloride intracellular channel 5
COL6A1 collagen, type VI, alpha 1
CRABP2 cellular retinoic acid binding protein 2
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DSC2 desmocollin 2
DUSP5 dual specificity phosphatase 5
ECM1 extracellular matrix protein 1
EMP1 epithelial membrane protein 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
G0S2 G0/G1 switch 2
GNAS GNAS complex locus
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HK2 hexokinase 2
HMOX1 heme oxygenase 1
ISG20 interferon stimulated exonuclease gene 20kDa
ITFG1 integrin alpha FG-GAP repeat containing 1
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MDK midkine (neurite growth-promoting factor 2)
MME membrane metallo-endopeptidase
MMP3 matrix metallopeptidase 3
MSMO1 methylsterol monooxygenase 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MYO1B myosin IB
NT5E 5'-nucleotidase, ecto (CD73)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PGK1 phosphoglycerate kinase 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLSCR3 phospholipid scramblase 3
PRKCI protein kinase C, iota
PRR7 proline rich 7 (synaptic)
R3HDM4 R3H domain containing 4
RAP2A RAP2A, member of RAS oncogene family
REG1B regenerating islet-derived 1 beta
RGCC regulator of cell cycle
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCUBE2 signal peptide, CUB domain, EGF-like 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SPINT1 serine peptidase inhibitor, Kunitz type 1
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SST somatostatin
STC2 stanniocalcin 2
TGFA transforming growth factor, alpha
TM4SF1 transmembrane 4 L six family member 1
TNIP1 TNFAIP3 interacting protein 1
TOX3 TOX high mobility group box family member 3
TRIB3 tribbles pseudokinase 3
TUBB2B tubulin, beta 2B class IIb
UPP1 uridine phosphorylase 1
WSB1 WD repeat and SOCS box containing 1
XBP1 X-box binding protein 1
YES1 YES proto-oncogene 1, Src family tyrosine kinase
ZFP36L1 ZFP36 ring finger protein-like 1
ZIC1 Zic family member 1

decreased expression

Symbol Name
ARID5B AT rich interactive domain 5B (MRF1-like)
BAX BCL2-associated X protein
BCL7B B-cell CLL/lymphoma 7B
CD58 CD58 molecule
CNPY3 canopy FGF signaling regulator 3
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTSH cathepsin H
CYTH1 cytohesin 1
DAPK1 death-associated protein kinase 1
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DKK1 dickkopf WNT signaling pathway inhibitor 1
ERAP2 endoplasmic reticulum aminopeptidase 2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FYB FYN binding protein
HOXC6 homeobox C6
IKZF1 IKAROS family zinc finger 1 (Ikaros)
KRT7 keratin 7, type II
MYB v-myb avian myeloblastosis viral oncogene homolog
NR2F2 nuclear receptor subfamily 2, group F, member 2
OPN3 opsin 3
PLAGL1 pleiomorphic adenoma gene-like 1
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
REEP1 receptor accessory protein 1
RGS4 regulator of G-protein signaling 4
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SLPI secretory leukocyte peptidase inhibitor
STAR steroidogenic acute regulatory protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TLR4 toll-like receptor 4
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10