BRD-K06217810_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

110 genes differentially expressed following the BRD-K06217810_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AP2B1 adaptor-related protein complex 2, beta 1 subunit
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT4 DNA-damage-inducible transcript 4
DFNA5 deafness, autosomal dominant 5
DUSP4 dual specificity phosphatase 4
ERBB2 erb-b2 receptor tyrosine kinase 2
GAA glucosidase, alpha; acid
GAS1 growth arrest-specific 1
H3F3B H3 histone, family 3B (H3.3B)
HIST1H2BD histone cluster 1, H2bd
IER5 immediate early response 5
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
KCTD12 potassium channel tetramerization domain containing 12
KYNU kynureninase
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP1B microtubule-associated protein 1B
MMP7 matrix metallopeptidase 7
MX1 MX dynamin-like GTPase 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NQO1 NAD(P)H dehydrogenase, quinone 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PGLS 6-phosphogluconolactonase
RAP1GAP RAP1 GTPase activating protein
RBM8A RNA binding motif protein 8A
RCN1 reticulocalbin 1, EF-hand calcium binding domain
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TXNRD1 thioredoxin reductase 1
VGLL4 vestigial-like family member 4
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
WDR45 WD repeat domain 45
YPEL5 yippee-like 5 (Drosophila)
ZFP36L1 ZFP36 ring finger protein-like 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AMD1 adenosylmethionine decarboxylase 1
ATAD2 ATPase family, AAA domain containing 2
C6ORF62 chromosome 6 open reading frame 62
CA2 carbonic anhydrase II
CALML3 calmodulin-like 3
CAV2 caveolin 2
CCNA2 cyclin A2
CCNE2 cyclin E2
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CENPN centromere protein N
CENPU centromere protein U
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CTSH cathepsin H
DEGS1 delta(4)-desaturase, sphingolipid 1
DLD dihydrolipoamide dehydrogenase
DNM1L dynamin 1-like
DPP4 dipeptidyl-peptidase 4
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
EMP2 epithelial membrane protein 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FEN1 flap structure-specific endonuclease 1
FXYD3 FXYD domain containing ion transport regulator 3
GINS2 GINS complex subunit 2 (Psf2 homolog)
GOLT1B golgi transport 1B
GTF2A2 general transcription factor IIA, 2, 12kDa
HIST1H4C histone cluster 1, H4c
HOMER2 homer scaffolding protein 2
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha
IGFBP5 insulin-like growth factor binding protein 5
IMPAD1 inositol monophosphatase domain containing 1
KRT15 keratin 15, type I
LGALS2 lectin, galactoside-binding, soluble, 2
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM4 minichromosome maintenance complex component 4
MREG melanoregulin
MSMB microseminoprotein, beta-
MUC1 mucin 1, cell surface associated
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NUDT21 nudix (nucleoside diphosphate linked moiety X)-type motif 21
NUP50 nucleoporin 50kDa
PDZK1 PDZ domain containing 1
PGK1 phosphoglycerate kinase 1
PITX1 paired-like homeodomain 1
PPP6C protein phosphatase 6, catalytic subunit
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PTS 6-pyruvoyltetrahydropterin synthase
RFC3 replication factor C (activator 1) 3, 38kDa
RRM1 ribonucleotide reductase M1
SAR1B secretion associated, Ras related GTPase 1B
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SELT selenoprotein T
SGK1 serum/glucocorticoid regulated kinase 1
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SMC2 structural maintenance of chromosomes 2
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TMEM70 transmembrane protein 70
TMX1 thioredoxin-related transmembrane protein 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TPD52L1 tumor protein D52-like 1
UBE2N ubiquitin-conjugating enzyme E2N
VLDLR very low density lipoprotein receptor
XBP1 X-box binding protein 1
ZWINT ZW10 interacting kinetochore protein