BRD-K06180729_DM163 BRD-K06180729_A375_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

165 genes differentially expressed following the BRD-K06180729_DM163 BRD-K06180729_A375_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
APP amyloid beta (A4) precursor protein
CA2 carbonic anhydrase II
CD200 CD200 molecule
CHI3L2 chitinase 3-like 2
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
COL2A1 collagen, type II, alpha 1
CTSZ cathepsin Z
EXT1 exostosin glycosyltransferase 1
F11R F11 receptor
FAM117A family with sequence similarity 117, member A
FST follistatin
GRB7 growth factor receptor-bound protein 7
GYPC glycophorin C (Gerbich blood group)
HAL histidine ammonia-lyase
HHEX hematopoietically expressed homeobox
HIST1H2BG histone cluster 1, H2bg
HLA-DRA major histocompatibility complex, class II, DR alpha
HOMER3 homer scaffolding protein 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
KIAA0226L KIAA0226-like
LAMP1 lysosomal-associated membrane protein 1
LOC100505650 uncharacterized LOC100505650
LRMP lymphoid-restricted membrane protein
MARCH3 membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MUC4 mucin 4, cell surface associated
NCAM1 neural cell adhesion molecule 1
NFE2 nuclear factor, erythroid 2
NPIPB3 nuclear pore complex interacting protein family, member B3
PAWR PRKC, apoptosis, WT1, regulator
PDIA3 protein disulfide isomerase family A, member 3
PRUNE2 prune homolog 2 (Drosophila)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RGCC regulator of cell cycle
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RNF130 ring finger protein 130
S100P S100 calcium binding protein P
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPON2 spondin 2, extracellular matrix protein
SPRR3 small proline-rich protein 3
TGFBI transforming growth factor, beta-induced, 68kDa
TSPAN5 tetraspanin 5
TSPAN7 tetraspanin 7
UBE2J1 ubiquitin-conjugating enzyme E2, J1
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADD3 adducin 3 (gamma)
ADI1 acireductone dioxygenase 1
ANXA3 annexin A3
APOD apolipoprotein D
AREG amphiregulin
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATF1 activating transcription factor 1
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BST2 bone marrow stromal cell antigen 2
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCL19 chemokine (C-C motif) ligand 19
CCL5 chemokine (C-C motif) ligand 5
CD59 CD59 molecule, complement regulatory protein
CETN3 centrin, EF-hand protein, 3
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CLIC5 chloride intracellular channel 5
CRYAB crystallin, alpha B
CRYZ crystallin, zeta (quinone reductase)
CSRP1 cysteine and glycine-rich protein 1
CTH cystathionine gamma-lyase
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL9 chemokine (C-X-C motif) ligand 9
DCN decorin
DLD dihydrolipoamide dehydrogenase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DST dystonin
DYNLT3 dynein, light chain, Tctex-type 3
EBNA1BP2 EBNA1 binding protein 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EPB41L2 erythrocyte membrane protein band 4.1-like 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FABP4 fatty acid binding protein 4, adipocyte
FBLN5 fibulin 5
FNBP1 formin binding protein 1
GATA6 GATA binding protein 6
GBP1 guanylate binding protein 1, interferon-inducible
GOLT1B golgi transport 1B
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPRC5A G protein-coupled receptor, class C, group 5, member A
GPRC5B G protein-coupled receptor, class C, group 5, member B
GSPT2 G1 to S phase transition 2
HSPA13 heat shock protein 70kDa family, member 13
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha
IFI44L interferon-induced protein 44-like
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP6 insulin-like growth factor binding protein 6
IGFBP7 insulin-like growth factor binding protein 7
IL18 interleukin 18
KANK1 KN motif and ankyrin repeat domains 1
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT17 keratin 17, type I
KYNU kynureninase
L1CAM L1 cell adhesion molecule
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LUM lumican
LY75 lymphocyte antigen 75
MET MET proto-oncogene, receptor tyrosine kinase
MPZL1 myelin protein zero-like 1
MXRA7 matrix-remodelling associated 7
NFIB nuclear factor I/B
NOV nephroblastoma overexpressed
NRIP1 nuclear receptor interacting protein 1
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
OXCT1 3-oxoacid CoA transferase 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBK PDZ binding kinase
PEG10 paternally expressed 10
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PNMAL1 paraneoplastic Ma antigen family-like 1
PPA1 pyrophosphatase (inorganic) 1
PRNP prion protein
PRPF4 pre-mRNA processing factor 4
PSIP1 PC4 and SFRS1 interacting protein 1
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTN pleiotrophin
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTX3 pentraxin 3, long
RCAN1 regulator of calcineurin 1
RP2 retinitis pigmentosa 2 (X-linked recessive)
S100A13 S100 calcium binding protein A13
S100A4 S100 calcium binding protein A4
SC5D sterol-C5-desaturase
SCGB2A2 secretoglobin, family 2A, member 2
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SMS spermine synthase
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SOAT1 sterol O-acyltransferase 1
STAT1 signal transducer and activator of transcription 1, 91kDa
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
SYNM synemin, intermediate filament protein
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TCAF1 TRPM8 channel-associated factor 1
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THBS1 thrombospondin 1
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TUBB2B tubulin, beta 2B class IIb
TVP23B trans-golgi network vesicle protein 23 homolog B (S. cerevisiae)
TXNDC9 thioredoxin domain containing 9
UFM1 ubiquitin-fold modifier 1
USP1 ubiquitin specific peptidase 1
USP22 ubiquitin specific peptidase 22
VTCN1 V-set domain containing T cell activation inhibitor 1