BRD-K05804044_AZ-628_HEPG2_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

104 genes differentially expressed following the BRD-K05804044_AZ-628_HEPG2_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
ADIRF adipogenesis regulatory factor
AKR1C3 aldo-keto reductase family 1, member C3
APOB apolipoprotein B
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
BEX1 brain expressed, X-linked 1
C1ORF115 chromosome 1 open reading frame 115
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFB complement factor B
CFI complement factor I
CLGN calmegin
CPNE3 copine III
DPYD dihydropyrimidine dehydrogenase
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FBXO7 F-box protein 7
GPRC5B G protein-coupled receptor, class C, group 5, member B
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HLA-C major histocompatibility complex, class I, C
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IL13RA2 interleukin 13 receptor, alpha 2
IRF9 interferon regulatory factor 9
KLK5 kallikrein-related peptidase 5
METTL7A methyltransferase like 7A
MSLN mesothelin
MTSS1 metastasis suppressor 1
MYH10 myosin, heavy chain 10, non-muscle
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NQO2 NAD(P)H dehydrogenase, quinone 2
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PDGFC platelet derived growth factor C
PRKACB protein kinase, cAMP-dependent, catalytic, beta
SCG2 secretogranin II
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SESN1 sestrin 1
SGCE sarcoglycan, epsilon
SOX9 SRY (sex determining region Y)-box 9
TES testin LIM domain protein
TF transferrin
TNS3 tensin 3
TSKU tsukushi, small leucine rich proteoglycan
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
XIST X inactive specific transcript (non-protein coding)
ZNF274 zinc finger protein 274
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AEBP1 AE binding protein 1
AMIGO2 adhesion molecule with Ig-like domain 2
AQP3 aquaporin 3 (Gill blood group)
AREG amphiregulin
ASPH aspartate beta-hydroxylase
BAG2 BCL2-associated athanogene 2
BASP1 brain abundant, membrane attached signal protein 1
CCNA1 cyclin A1
CCND1 cyclin D1
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CFLAR CASP8 and FADD-like apoptosis regulator
COL1A1 collagen, type I, alpha 1
COL4A6 collagen, type IV, alpha 6
COL5A1 collagen, type V, alpha 1
CTGF connective tissue growth factor
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENO1 enolase 1, (alpha)
EREG epiregulin
ERO1L ERO1-like (S. cerevisiae)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FBLN1 fibulin 1
G0S2 G0/G1 switch 2
GOLT1B golgi transport 1B
GRWD1 glutamate-rich WD repeat containing 1
HACD3 3-hydroxyacyl-CoA dehydratase 3
IER3 immediate early response 3
ISG20 interferon stimulated exonuclease gene 20kDa
ITGB5 integrin, beta 5
KDM5D lysine (K)-specific demethylase 5D
LTF lactotransferrin
MALL mal, T-cell differentiation protein-like
MYO1B myosin IB
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NME1 NME/NM23 nucleoside diphosphate kinase 1
NRN1 neuritin 1
PFKP phosphofructokinase, platelet
PHKA1 phosphorylase kinase, alpha 1 (muscle)
PHLDA2 pleckstrin homology-like domain, family A, member 2
PNP purine nucleoside phosphorylase
RAD51C RAD51 paralog C
RPS4Y1 ribosomal protein S4, Y-linked 1
SACS sacsin molecular chaperone
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
TACSTD2 tumor-associated calcium signal transducer 2
TAGLN transgelin
TFF3 trefoil factor 3 (intestinal)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TMEM2 transmembrane protein 2
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
VCAN versican
YBX3 Y box binding protein 3