BRD-K05804044_AZ-628_HEPG2_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

122 genes differentially expressed following the BRD-K05804044_AZ-628_HEPG2_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
AFP alpha-fetoprotein
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHSG alpha-2-HS-glycoprotein
AMACR alpha-methylacyl-CoA racemase
AMDHD2 amidohydrolase domain containing 2
ANO10 anoctamin 10
ANPEP alanyl (membrane) aminopeptidase
APOA2 apolipoprotein A-II
APOB apolipoprotein B
APOC1 apolipoprotein C-I
APOC3 apolipoprotein C-III
APOM apolipoprotein M
ARG1 arginase 1
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BEX4 brain expressed, X-linked 4
C5 complement component 5
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFB complement factor B
CLU clusterin
DACH1 dachshund family transcription factor 1
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DHRS1 dehydrogenase/reductase (SDR family) member 1
EPHX2 epoxide hydrolase 2, cytoplasmic
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FABP1 fatty acid binding protein 1, liver
FAM117A family with sequence similarity 117, member A
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GAS1 growth arrest-specific 1
GLUL glutamate-ammonia ligase
GPRC5B G protein-coupled receptor, class C, group 5, member B
GSTA1 glutathione S-transferase alpha 1
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HMOX1 heme oxygenase 1
HP haptoglobin
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IRS2 insulin receptor substrate 2
KIAA0226L KIAA0226-like
KLK5 kallikrein-related peptidase 5
KNG1 kininogen 1
LAMP2 lysosomal-associated membrane protein 2
LYPD1 LY6/PLAUR domain containing 1
MAN1C1 mannosidase, alpha, class 1C, member 1
METTL7A methyltransferase like 7A
NUPR1 nuclear protein, transcriptional regulator, 1
PBLD phenazine biosynthesis-like protein domain containing
PCP4 Purkinje cell protein 4
PDZK1IP1 PDZK1 interacting protein 1
PHGDH phosphoglycerate dehydrogenase
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RPS4Y1 ribosomal protein S4, Y-linked 1
SCG5 secretogranin V
SELENBP1 selenium binding protein 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VAT1 vesicle amine transport 1

decreased expression

Symbol Name
ADGRF5 adhesion G protein-coupled receptor F5
AKAP12 A kinase (PRKA) anchor protein 12
ANXA1 annexin A1
CCDC86 coiled-coil domain containing 86
CCND1 cyclin D1
CD36 CD36 molecule (thrombospondin receptor)
COL3A1 collagen, type III, alpha 1
COL6A3 collagen, type VI, alpha 3
CTGF connective tissue growth factor
DSG2 desmoglein 2
DUSP6 dual specificity phosphatase 6
EBNA1BP2 EBNA1 binding protein 2
EFHD1 EF-hand domain family, member D1
FBN1 fibrillin 1
GEM GTP binding protein overexpressed in skeletal muscle
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GOLT1B golgi transport 1B
GPRC5A G protein-coupled receptor, class C, group 5, member A
ICAM1 intercellular adhesion molecule 1
ICAM2 intercellular adhesion molecule 2
IER3 immediate early response 3
IFI44L interferon-induced protein 44-like
IGKC immunoglobulin kappa constant
IL27RA interleukin 27 receptor, alpha
INPP1 inositol polyphosphate-1-phosphatase
ITGA6 integrin, alpha 6
ITGB5 integrin, beta 5
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KRT14 keratin 14, type I
KRT18 keratin 18, type I
KRT19 keratin 19, type I
LDHB lactate dehydrogenase B
LMCD1 LIM and cysteine-rich domains 1
MAOB monoamine oxidase B
MEF2C myocyte enhancer factor 2C
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEBL nebulette
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFIB nuclear factor I/B
NRN1 neuritin 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
RECQL RecQ helicase-like
S100P S100 calcium binding protein P
SDF2L1 stromal cell-derived factor 2-like 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SPARCL1 SPARC-like 1 (hevin)
SRGN serglycin
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMP1 TIMP metallopeptidase inhibitor 1
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2