BRD-K05804044_AZ-628_A375_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

295 genes differentially expressed following the BRD-K05804044_AZ-628_A375_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTA2 actin, alpha 2, smooth muscle, aorta
ADD3 adducin 3 (gamma)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
AHNAK2 AHNAK nucleoprotein 2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDOA aldolase A, fructose-bisphosphate
ANXA9 annexin A9
AQP1 aquaporin 1 (Colton blood group)
ARMCX6 armadillo repeat containing, X-linked 6
ASPN asporin
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BEX1 brain expressed, X-linked 1
BEX4 brain expressed, X-linked 4
BTG2 BTG family, member 2
C14ORF132 chromosome 14 open reading frame 132
C3 complement component 3
C9ORF3 chromosome 9 open reading frame 3
CAPN3 calpain 3, (p94)
CAV1 caveolin 1, caveolae protein, 22kDa
CCL2 chemokine (C-C motif) ligand 2
CCND2 cyclin D2
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CFI complement factor I
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLIC3 chloride intracellular channel 3
COL1A2 collagen, type I, alpha 2
COL21A1 collagen, type XXI, alpha 1
COL5A1 collagen, type V, alpha 1
COLEC12 collectin sub-family member 12
CP ceruloplasmin (ferroxidase)
CRYAB crystallin, alpha B
CSRP1 cysteine and glycine-rich protein 1
CYBA cytochrome b-245, alpha polypeptide
CYFIP2 cytoplasmic FMR1 interacting protein 2
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DCN decorin
DDB2 damage-specific DNA binding protein 2, 48kDa
DDR1 discoidin domain receptor tyrosine kinase 1
DDR2 discoidin domain receptor tyrosine kinase 2
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DHCR24 24-dehydrocholesterol reductase
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EFNA1 ephrin-A1
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FADS1 fatty acid desaturase 1
FAM134B family with sequence similarity 134, member B
FAM63A family with sequence similarity 63, member A
FDXR ferredoxin reductase
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FNBP1 formin binding protein 1
FOXO1 forkhead box O1
GABARAP GABA(A) receptor-associated protein
GOLGA8B golgin A8 family, member B
GPM6B glycoprotein M6B
GPX1 glutathione peroxidase 1
GPX3 glutathione peroxidase 3
GSN gelsolin
GSTA1 glutathione S-transferase alpha 1
GSTA4 glutathione S-transferase alpha 4
GSTP1 glutathione S-transferase pi 1
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-E major histocompatibility complex, class I, E
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGN3 high mobility group nucleosomal binding domain 3
HSPA2 heat shock 70kDa protein 2
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IGFBP6 insulin-like growth factor binding protein 6
IL6ST interleukin 6 signal transducer
IRF9 interferon regulatory factor 9
ISOC1 isochorismatase domain containing 1
JUP junction plakoglobin
KRT14 keratin 14, type I
KRT19 keratin 19, type I
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial)
LHFP lipoma HMGIC fusion partner
LUM lumican
LY96 lymphocyte antigen 96
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAGED1 melanoma antigen family D1
MAGED2 melanoma antigen family D2
MATN2 matrilin 2
MEF2C myocyte enhancer factor 2C
MEIS1 Meis homeobox 1
METTL7A methyltransferase like 7A
MGP matrix Gla protein
MSRB2 methionine sulfoxide reductase B2
MTUS1 microtubule associated tumor suppressor 1
MVP major vault protein
MXRA5 matrix-remodelling associated 5
MYLK myosin light chain kinase
MYO6 myosin VI
NCAM1 neural cell adhesion molecule 1
NDRG2 NDRG family member 2
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NPC2 Niemann-Pick disease, type C2
NRCAM neuronal cell adhesion molecule
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM4 olfactomedin 4
OLFML2A olfactomedin-like 2A
ORAI3 ORAI calcium release-activated calcium modulator 3
OSBPL9 oxysterol binding protein-like 9
PBX1 pre-B-cell leukemia homeobox 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFD platelet derived growth factor D
PDIA3 protein disulfide isomerase family A, member 3
PFN2 profilin 2
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLA2G16 phospholipase A2, group XVI
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRAF2 PRA1 domain family, member 2
PRKCD protein kinase C, delta
PRSS23 protease, serine, 23
PTCH1 patched 1
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
PYGL phosphorylase, glycogen, liver
QPRT quinolinate phosphoribosyltransferase
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RBP1 retinol binding protein 1, cellular
REEP1 receptor accessory protein 1
RGS1 regulator of G-protein signaling 1
S100A4 S100 calcium binding protein A4
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEPP1 selenoprotein P, plasma, 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SLPI secretory leukocyte peptidase inhibitor
SOX2 SRY (sex determining region Y)-box 2
SPATA20 spermatogenesis associated 20
SSFA2 sperm specific antigen 2
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STON1 stonin 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
SVIL supervillin
SYNM synemin, intermediate filament protein
SYNPO synaptopodin
SYT11 synaptotagmin XI
TAGLN transgelin
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TNS1 tensin 1
TNS3 tensin 3
TOX thymocyte selection-associated high mobility group box
TPD52L1 tumor protein D52-like 1
TRIM2 tripartite motif containing 2
TRIM22 tripartite motif containing 22
TUBA1A tubulin, alpha 1a
VASH1 vasohibin 1
VAT1 vesicle amine transport 1
VCAN versican
VTCN1 V-set domain containing T cell activation inhibitor 1
WDR45 WD repeat domain 45
WIPI1 WD repeat domain, phosphoinositide interacting 1
WSB1 WD repeat and SOCS box containing 1
YPEL5 yippee-like 5 (Drosophila)
ZCCHC24 zinc finger, CCHC domain containing 24

decreased expression

Symbol Name
AGTR1 angiotensin II receptor, type 1
AQP3 aquaporin 3 (Gill blood group)
ARL4A ADP-ribosylation factor-like 4A
BAG3 BCL2-associated athanogene 3
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BPHL biphenyl hydrolase-like (serine hydrolase)
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CCDC86 coiled-coil domain containing 86
CCND1 cyclin D1
CD3EAP CD3e molecule, epsilon associated protein
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDK2 cyclin-dependent kinase 2
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
CST1 cystatin SN
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
DEK DEK proto-oncogene
DKC1 dyskeratosis congenita 1, dyskerin
DKK1 dickkopf WNT signaling pathway inhibitor 1
DSP desmoplakin
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP2 dual specificity phosphatase 2
DUSP4 dual specificity phosphatase 4
ECT2 epithelial cell transforming 2
EFHD2 EF-hand domain family, member D2
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EIF5A eukaryotic translation initiation factor 5A
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENO1 enolase 1, (alpha)
ENOPH1 enolase-phosphatase 1
EPHA2 EPH receptor A2
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FEN1 flap structure-specific endonuclease 1
FKBP11 FK506 binding protein 11, 19 kDa
FOSL1 FOS-like antigen 1
GAL galanin/GMAP prepropeptide
GCH1 GTP cyclohydrolase 1
H2AFZ H2A histone family, member Z
HMGA1 high mobility group AT-hook 1
HMGA2 high mobility group AT-hook 2
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IER3 immediate early response 3
INHBA inhibin, beta A
IPO7 importin 7
ITGB5 integrin, beta 5
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCM4 minichromosome maintenance complex component 4
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MME membrane metallo-endopeptidase
MMP12 matrix metallopeptidase 12
MOK MOK protein kinase
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MSH2 mutS homolog 2
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NFE2L3 nuclear factor, erythroid 2-like 3
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NR1H2 nuclear receptor subfamily 1, group H, member 2
NRGN neurogranin (protein kinase C substrate, RC3)
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PCOLCE2 procollagen C-endopeptidase enhancer 2
PCSK1 proprotein convertase subtilisin/kexin type 1
PDHX pyruvate dehydrogenase complex, component X
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAUR plasminogen activator, urokinase receptor
PNP purine nucleoside phosphorylase
PPIF peptidylprolyl isomerase F
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
PUS7 pseudouridylate synthase 7 (putative)
RAN RAN, member RAS oncogene family
RFC3 replication factor C (activator 1) 3, 38kDa
RRM2 ribonucleotide reductase M2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SACS sacsin molecular chaperone
SEH1L SEH1-like (S. cerevisiae)
SHB Src homology 2 domain containing adaptor protein B
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC35F2 solute carrier family 35, member F2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
ST14 suppression of tumorigenicity 14 (colon carcinoma)
STX1A syntaxin 1A (brain)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TCTN1 tectonic family member 1
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TFRC transferrin receptor
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM2 transmembrane protein 2
TMPO thymopoietin
TRIP13 thyroid hormone receptor interactor 13
TUBB2A tubulin, beta 2A class IIa
TYRP1 tyrosinase-related protein 1
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
USP1 ubiquitin specific peptidase 1
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast)
WDR43 WD repeat domain 43
WSB2 WD repeat and SOCS box containing 2
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing