BRD-K05649647_-666_SW620_6.0_h_20.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

85 genes differentially expressed following the BRD-K05649647_-666_SW620_6.0_h_20.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AARS alanyl-tRNA synthetase
AIM1 absent in melanoma 1
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPH aspartate beta-hydroxylase
ASS1 argininosuccinate synthase 1
ATF4 activating transcription factor 4
BHLHE41 basic helix-loop-helix family, member e41
BLNK B-cell linker
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNG2 cyclin G2
CD24 CD24 molecule
CD52 CD52 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEP57 centrosomal protein 57kDa
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COMP cartilage oligomeric matrix protein
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DEPTOR DEP domain containing MTOR-interacting protein
DLD dihydrolipoamide dehydrogenase
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DSP desmoplakin
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EPCAM epithelial cell adhesion molecule
GARS glycyl-tRNA synthetase
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
HYOU1 hypoxia up-regulated 1
INHBA inhibin, beta A
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
JCHAIN joining chain of multimeric IgA and IgM
KRT18 keratin 18, type I
LAMB3 laminin, beta 3
LGALS4 lectin, galactoside-binding, soluble, 4
LRRC15 leucine rich repeat containing 15
LUM lumican
MAN1A1 mannosidase, alpha, class 1A, member 1
MARS methionyl-tRNA synthetase
MBNL2 muscleblind-like splicing regulator 2
MZB1 marginal zone B and B1 cell-specific protein
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NT5E 5'-nucleotidase, ecto (CD73)
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OLFM4 olfactomedin 4
PHLDA1 pleckstrin homology-like domain, family A, member 1
PSAT1 phosphoserine aminotransferase 1
RPL10 ribosomal protein L10
S100A13 S100 calcium binding protein A13
S100A14 S100 calcium binding protein A14
SARS seryl-tRNA synthetase
SDC1 syndecan 1
SDF2L1 stromal cell-derived factor 2-like 1
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SHB Src homology 2 domain containing adaptor protein B
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC38A1 solute carrier family 38, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TFF1 trefoil factor 1
THBS2 thrombospondin 2
TPD52 tumor protein D52
TPM2 tropomyosin 2 (beta)
TRIB3 tribbles pseudokinase 3
VCAN versican
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AURKA aurora kinase A
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
FABP7 fatty acid binding protein 7, brain
HBB hemoglobin, beta
HLTF helicase-like transcription factor
HMGN3 high mobility group nucleosomal binding domain 3
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KAZN kazrin, periplakin interacting protein
LBH limb bud and heart development
MEIS1 Meis homeobox 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PLTP phospholipid transfer protein
TSPAN5 tetraspanin 5
WFS1 Wolfram syndrome 1 (wolframin)