BRD-K05649647_-666_MCF7_6.0_h_20.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

153 genes differentially expressed following the BRD-K05649647_-666_MCF7_6.0_h_20.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARF4 ADP-ribosylation factor 4
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3
ARHGAP29 Rho GTPase activating protein 29
ARL1 ADP-ribosylation factor-like 1
ARMCX3 armadillo repeat containing, X-linked 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
BET1 Bet1 golgi vesicular membrane trafficking protein
CANX calnexin
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CKAP4 cytoskeleton-associated protein 4
CREB3L2 cAMP responsive element binding protein 3-like 2
CRELD2 cysteine-rich with EGF-like domains 2
DACH1 dachshund family transcription factor 1
DDIT3 DNA-damage-inducible transcript 3
DES desmin
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EREG epiregulin
FBN2 fibrillin 2
FICD FIC domain containing
FKBP11 FK506 binding protein 11, 19 kDa
FKBP14 FK506 binding protein 14, 22 kDa
FNDC3B fibronectin type III domain containing 3B
FPR1 formyl peptide receptor 1
G0S2 G0/G1 switch 2
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
GOLGA4 golgin A4
GORASP2 golgi reassembly stacking protein 2, 55kDa
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HYOU1 hypoxia up-regulated 1
IGFBP5 insulin-like growth factor binding protein 5
KCTD5 potassium channel tetramerization domain containing 5
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
LOX lysyl oxidase
MAGT1 magnesium transporter 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MANF mesencephalic astrocyte-derived neurotrophic factor
MAP1B microtubule-associated protein 1B
MBNL2 muscleblind-like splicing regulator 2
MCFD2 multiple coagulation factor deficiency 2
MIS12 MIS12 kinetochore complex component
MT1G metallothionein 1G
NANS N-acetylneuraminic acid synthase
NFIL3 nuclear factor, interleukin 3 regulated
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
P4HB prolyl 4-hydroxylase, beta polypeptide
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDIA4 protein disulfide isomerase family A, member 4
PDIA6 protein disulfide isomerase family A, member 6
PGM3 phosphoglucomutase 3
PPIB peptidylprolyl isomerase B (cyclophilin B)
PRAME preferentially expressed antigen in melanoma
PRUNE2 prune homolog 2 (Drosophila)
RABAC1 Rab acceptor 1 (prenylated)
RAD9A RAD9 homolog A (S. pombe)
RNASE4 ribonuclease, RNase A family, 4
RND3 Rho family GTPase 3
S100A12 S100 calcium binding protein A12
S100A8 S100 calcium binding protein A8
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A1 secretoglobin, family 2A, member 1
SCML1 sex comb on midleg-like 1 (Drosophila)
SDF2L1 stromal cell-derived factor 2-like 1
SEC13 SEC13 homolog (S. cerevisiae)
SEC23B Sec23 homolog B (S. cerevisiae)
SEC24D SEC24 family member D
SEC61B Sec61 beta subunit
SEC61G Sec61 gamma subunit
SEC63 SEC63 homolog (S. cerevisiae)
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SERP1 stress-associated endoplasmic reticulum protein 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SLC35B1 solute carrier family 35, member B1
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPCS3 signal peptidase complex subunit 3 homolog (S. cerevisiae)
SSR1 signal sequence receptor, alpha
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
SUCO SUN domain containing ossification factor
TGFBI transforming growth factor, beta-induced, 68kDa
TMED2 transmembrane emp24 domain trafficking protein 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM214 transmembrane protein 214
TMEM243 transmembrane protein 243, mitochondrial
TMEM39A transmembrane protein 39A
TMEM41B transmembrane protein 41B
TUFT1 tuftelin 1
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UFM1 ubiquitin-fold modifier 1
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VCAN versican
VEGFA vascular endothelial growth factor A
VIM vimentin
WFS1 Wolfram syndrome 1 (wolframin)
WIPI1 WD repeat domain, phosphoinositide interacting 1

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ADD3 adducin 3 (gamma)
AK4 adenylate kinase 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
APLP2 amyloid beta (A4) precursor-like protein 2
APOD apolipoprotein D
B3GNT1
CCND1 cyclin D1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
COL10A1 collagen, type X, alpha 1
CPE carboxypeptidase E
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
EGR3 early growth response 3
GAS1 growth arrest-specific 1
GPC3 glypican 3
GRSF1 G-rich RNA sequence binding factor 1
HACD2 3-hydroxyacyl-CoA dehydratase 2
HOXC6 homeobox C6
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IGFBP6 insulin-like growth factor binding protein 6
ITPK1 inositol-tetrakisphosphate 1-kinase
JADE2 jade family PHD finger 2
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
NQO1 NAD(P)H dehydrogenase, quinone 1
PDGFA platelet-derived growth factor alpha polypeptide
PODXL podocalyxin-like
SEPT11 septin 11
SFN stratifin
SPINK1 serine peptidase inhibitor, Kazal type 1
TSPAN3 tetraspanin 3
TUBB2A tubulin, beta 2A class IIa
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
WWP1 WW domain containing E3 ubiquitin protein ligase 1