BRD-K05649647_-666_HA1E_6.0_h_20.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

178 genes differentially expressed following the BRD-K05649647_-666_HA1E_6.0_h_20.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
BET1 Bet1 golgi vesicular membrane trafficking protein
BTG3 BTG family, member 3
CA2 carbonic anhydrase II
CANX calnexin
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCR2 chemokine (C-C motif) receptor 2
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CREB3L2 cAMP responsive element binding protein 3-like 2
CRELD2 cysteine-rich with EGF-like domains 2
CX3CL1 chemokine (C-X3-C motif) ligand 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DEFA4 defensin, alpha 4, corticostatin
DERL2 derlin 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DUSP6 dual specificity phosphatase 6
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF5 eukaryotic translation initiation factor 5
EPRS glutamyl-prolyl-tRNA synthetase
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FICD FIC domain containing
FKBP11 FK506 binding protein 11, 19 kDa
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GTPBP2 GTP binding protein 2
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HYOU1 hypoxia up-regulated 1
IARS isoleucyl-tRNA synthetase
IFRD1 interferon-related developmental regulator 1
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLV3-19 immunoglobulin lambda variable 3-19
ISG20 interferon stimulated exonuclease gene 20kDa
KLK5 kallikrein-related peptidase 5
MANF mesencephalic astrocyte-derived neurotrophic factor
MARS methionyl-tRNA synthetase
MIS12 MIS12 kinetochore complex component
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYC v-myc avian myelocytomatosis viral oncogene homolog
MZB1 marginal zone B and B1 cell-specific protein
NFIL3 nuclear factor, interleukin 3 regulated
NUCB2 nucleobindin 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDIA4 protein disulfide isomerase family A, member 4
PDIA6 protein disulfide isomerase family A, member 6
PLVAP plasmalemma vesicle associated protein
POU2AF1 POU class 2 associating factor 1
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PSAT1 phosphoserine aminotransferase 1
RAB2A RAB2A, member RAS oncogene family
RAD9A RAD9 homolog A (S. pombe)
SARS seryl-tRNA synthetase
SDF2L1 stromal cell-derived factor 2-like 1
SEC63 SEC63 homolog (S. cerevisiae)
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SERP1 stress-associated endoplasmic reticulum protein 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC35B1 solute carrier family 35, member B1
SLC38A1 solute carrier family 38, member 1
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
STC2 stanniocalcin 2
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TCEA1 transcription elongation factor A (SII), 1
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
UBE2J1 ubiquitin-conjugating enzyme E2, J1
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATF5 activating transcription factor 5
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
AURKA aurora kinase A
B3GNT1
C1GALT1C1 C1GALT1-specific chaperone 1
C1R complement component 1, r subcomponent
CBR3 carbonyl reductase 3
CCNF cyclin F
CD58 CD58 molecule
CRYAB crystallin, alpha B
CTSB cathepsin B
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
ECI2 enoyl-CoA delta isomerase 2
EID1 EP300 interacting inhibitor of differentiation 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FOXO4 forkhead box O4
FZD7 frizzled class receptor 7
GAS1 growth arrest-specific 1
GAS2L1 growth arrest-specific 2 like 1
GPR137B G protein-coupled receptor 137B
GPX3 glutathione peroxidase 3
H2AFX H2A histone family, member X
HLTF helicase-like transcription factor
HN1 hematological and neurological expressed 1
HOXA10 homeobox A10
HOXA5 homeobox A5
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
JADE2 jade family PHD finger 2
KANK2 KN motif and ankyrin repeat domains 2
KIAA0232 KIAA0232
KRT19 keratin 19, type I
LBH limb bud and heart development
LMNA lamin A/C
MAGED1 melanoma antigen family D1
MARCKSL1 MARCKS-like 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
NAV3 neuron navigator 3
NDRG3 NDRG family member 3
NRN1 neuritin 1
RBP1 retinol binding protein 1, cellular
RHOBTB3 Rho-related BTB domain containing 3
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SFN stratifin
SKP1 S-phase kinase-associated protein 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SMS spermine synthase
SOX4 SRY (sex determining region Y)-box 4
SUMO2 small ubiquitin-like modifier 2
TBC1D4 TBC1 domain family, member 4
TGM2 transglutaminase 2
TMEM14A transmembrane protein 14A
TMEM164 transmembrane protein 164
TUBB tubulin, beta class I
TUBB2A tubulin, beta 2A class IIa
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
UBE2S ubiquitin-conjugating enzyme E2S
WSB2 WD repeat and SOCS box containing 2
ZBTB20 zinc finger and BTB domain containing 20
ZCCHC24 zinc finger, CCHC domain containing 24