BRD-K05510762_Granisetron_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

136 genes differentially expressed following the BRD-K05510762_Granisetron_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
ALG8 ALG8, alpha-1,3-glucosyltransferase
BEX1 brain expressed, X-linked 1
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
CARKD carbohydrate kinase domain containing
CCL2 chemokine (C-C motif) ligand 2
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CTNND1 catenin (cadherin-associated protein), delta 1
CXCL12 chemokine (C-X-C motif) ligand 12
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCTD dCMP deaminase
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
EFHD1 EF-hand domain family, member D1
FBP1 fructose-1,6-bisphosphatase 1
FXYD3 FXYD domain containing ion transport regulator 3
GALC galactosylceramidase
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10
GATA3 GATA binding protein 3
GLDC glycine dehydrogenase (decarboxylating)
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GUSB glucuronidase, beta
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DMB major histocompatibility complex, class II, DM beta
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HOMER2 homer scaffolding protein 2
HOMER3 homer scaffolding protein 3
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP4 insulin-like growth factor binding protein 4
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
LTBP3 latent transforming growth factor beta binding protein 3
MAOA monoamine oxidase A
NET1 neuroepithelial cell transforming 1
NPC2 Niemann-Pick disease, type C2
OLFML3 olfactomedin-like 3
PAX8 paired box 8
PDLIM4 PDZ and LIM domain 4
POSTN periostin, osteoblast specific factor
PRAME preferentially expressed antigen in melanoma
PROM1 prominin 1
RALB v-ral simian leukemia viral oncogene homolog B
RGS4 regulator of G-protein signaling 4
RRBP1 ribosome binding protein 1
SFRP1 secreted frizzled-related protein 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SRGN serglycin
SRPX sushi-repeat containing protein, X-linked
SRSF5 serine/arginine-rich splicing factor 5
STC2 stanniocalcin 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TM4SF4 transmembrane 4 L six family member 4
TMEM2 transmembrane protein 2
TRAPPC6A trafficking protein particle complex 6A
TXNIP thioredoxin interacting protein
VIM vimentin

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACAT2 acetyl-CoA acetyltransferase 2
ACPP acid phosphatase, prostate
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AQP3 aquaporin 3 (Gill blood group)
ARL4C ADP-ribosylation factor-like 4C
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
BTG3 BTG family, member 3
CALD1 caldesmon 1
CD9 CD9 molecule
CKB creatine kinase, brain
COCH cochlin
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CSK c-src tyrosine kinase
CSTA cystatin A (stefin A)
CTSK cathepsin K
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL13 chemokine (C-X-C motif) ligand 13
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPYSL3 dihydropyrimidinase-like 3
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EPB41L2 erythrocyte membrane protein band 4.1-like 2
FAM129A family with sequence similarity 129, member A
FN1 fibronectin 1
FOXF2 forkhead box F2
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GSN gelsolin
GUSBP3 glucuronidase, beta pseudogene 3
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HOPX HOP homeobox
HOXD1 homeobox D1
HSPA1A heat shock 70kDa protein 1A
IFI16 interferon, gamma-inducible protein 16
IL18 interleukin 18
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KRT15 keratin 15, type I
KYNU kynureninase
LAMP3 lysosomal-associated membrane protein 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1B microtubule-associated protein 1B
MBP myelin basic protein
MXRA7 matrix-remodelling associated 7
NR4A2 nuclear receptor subfamily 4, group A, member 2
OLFM1 olfactomedin 1
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase
PDE4B phosphodiesterase 4B, cAMP-specific
PEG10 paternally expressed 10
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PLEK pleckstrin
PRNP prion protein
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RCAN2 regulator of calcineurin 2
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPL37A ribosomal protein L37a
S100A9 S100 calcium binding protein A9
SEPP1 selenoprotein P, plasma, 1
SERINC3 serine incorporator 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SGCE sarcoglycan, epsilon
SH3BGRL SH3 domain binding glutamate-rich protein like
SKP1 S-phase kinase-associated protein 1
SLC38A1 solute carrier family 38, member 1
SNX7 sorting nexin 7
TATDN2 TatD DNase domain containing 2
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TMEM45A transmembrane protein 45A
TPR translocated promoter region, nuclear basket protein
TSPAN12 tetraspanin 12
XIST X inactive specific transcript (non-protein coding)
ZFP36L2 ZFP36 ring finger protein-like 2