BRD-K05434375_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

89 genes differentially expressed following the BRD-K05434375_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
APOD apolipoprotein D
BSG basigin (Ok blood group)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
COL4A5 collagen, type IV, alpha 5
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
DST dystonin
EMX2 empty spiracles homeobox 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FABP4 fatty acid binding protein 4, adipocyte
FAM198B family with sequence similarity 198, member B
FGL2 fibrinogen-like 2
GBP1 guanylate binding protein 1, interferon-inducible
HSPH1 heat shock 105kDa/110kDa protein 1
IDO1 indoleamine 2,3-dioxygenase 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
ISOC1 isochorismatase domain containing 1
ITM2A integral membrane protein 2A
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
MAP7 microtubule-associated protein 7
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
PI3 peptidase inhibitor 3, skin-derived
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCD protein kinase C, delta
PTHLH parathyroid hormone-like hormone
RHOH ras homolog family member H
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SELENBP1 selenium binding protein 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SOX9 SRY (sex determining region Y)-box 9
SPARCL1 SPARC-like 1 (hevin)
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
TFF1 trefoil factor 1
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TWF1 twinfilin actin binding protein 1
TXNIP thioredoxin interacting protein
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1

decreased expression

Symbol Name
ALOX5 arachidonate 5-lipoxygenase
ANKRD10 ankyrin repeat domain 10
ANXA6 annexin A6
BRCA1 breast cancer 1, early onset
CBS cystathionine-beta-synthase
CEP55 centrosomal protein 55kDa
CES1 carboxylesterase 1
COL11A1 collagen, type XI, alpha 1
CTSZ cathepsin Z
DEFB1 defensin, beta 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
FAM216A family with sequence similarity 216, member A
FPGS folylpolyglutamate synthase
GALE UDP-galactose-4-epimerase
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GLS glutaminase
IFI44L interferon-induced protein 44-like
ISG15 ISG15 ubiquitin-like modifier
KRCC1 lysine-rich coiled-coil 1
KRT19 keratin 19, type I
MACF1 microtubule-actin crosslinking factor 1
MET MET proto-oncogene, receptor tyrosine kinase
MGLL monoglyceride lipase
MX1 MX dynamin-like GTPase 1
MX2 MX dynamin-like GTPase 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NMT1 N-myristoyltransferase 1
NUP62 nucleoporin 62kDa
PBX3 pre-B-cell leukemia homeobox 3
PLS3 plastin 3
SENP6 SUMO1/sentrin specific peptidase 6
SFTPA2 surfactant protein A2
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC35E3 solute carrier family 35, member E3
TARBP1 TAR (HIV-1) RNA binding protein 1
TFPI2 tissue factor pathway inhibitor 2
TKTL1 transketolase-like 1
TMEM5 transmembrane protein 5
UBE3C ubiquitin protein ligase E3C
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)