BRD-K05396879_15-delta prostaglandin J2_SKB_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

150 genes differentially expressed following the BRD-K05396879_15-delta prostaglandin J2_SKB_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AK4 adenylate kinase 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ANPEP alanyl (membrane) aminopeptidase
ANXA7 annexin A7
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
BAG3 BCL2-associated athanogene 3
BLVRB biliverdin reductase B
BMP7 bone morphogenetic protein 7
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CA12 carbonic anhydrase XII
CBR1 carbonyl reductase 1
CBR3 carbonyl reductase 3
CHPT1 choline phosphotransferase 1
CLIC1 chloride intracellular channel 1
CLU clusterin
CTSB cathepsin B
CTSL cathepsin L
CXCL5 chemokine (C-X-C motif) ligand 5
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DSP desmoplakin
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF4E eukaryotic translation initiation factor 4E
EMC3 ER membrane protein complex subunit 3
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
G6PD glucose-6-phosphate dehydrogenase
GCH1 GTP cyclohydrolase 1
GCLM glutamate-cysteine ligase, modifier subunit
GLA galactosidase, alpha
GULP1 GULP, engulfment adaptor PTB domain containing 1
HAS2 hyaluronan synthase 2
HK1 hexokinase 1
HMOX1 heme oxygenase 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA1A heat shock 70kDa protein 1A
IL13RA2 interleukin 13 receptor, alpha 2
KDM5D lysine (K)-specific demethylase 5D
KYNU kynureninase
LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
LEF1 lymphoid enhancer-binding factor 1
MAB21L2 mab-21-like 2 (C. elegans)
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MCUR1 mitochondrial calcium uniporter regulator 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MME membrane metallo-endopeptidase
MMP1 matrix metallopeptidase 1
MSX1 msh homeobox 1
NQO1 NAD(P)H dehydrogenase, quinone 1
PDLIM4 PDZ and LIM domain 4
PGRMC1 progesterone receptor membrane component 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIR pirin (iron-binding nuclear protein)
PRDX1 peroxiredoxin 1
RAB11A RAB11A, member RAS oncogene family
RPS4Y1 ribosomal protein S4, Y-linked 1
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SOAT1 sterol O-acyltransferase 1
SOX9 SRY (sex determining region Y)-box 9
TBX3 T-box 3
TLR4 toll-like receptor 4
TNPO1 transportin 1
TOM1L1 target of myb1 (chicken)-like 1
TRIM16 tripartite motif containing 16
TXN thioredoxin
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WFS1 Wolfram syndrome 1 (wolframin)
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ABLIM1 actin binding LIM protein 1
ACAT2 acetyl-CoA acetyltransferase 2
ACTA1 actin, alpha 1, skeletal muscle
ACTC1 actin, alpha, cardiac muscle 1
ADARB1 adenosine deaminase, RNA-specific, B1
ANKRD10 ankyrin repeat domain 10
ANOS1 anosmin 1
AQP1 aquaporin 1 (Colton blood group)
ARHGAP29 Rho GTPase activating protein 29
ARMCX2 armadillo repeat containing, X-linked 2
AUTS2 autism susceptibility candidate 2
C7 complement component 7
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CDC25B cell division cycle 25B
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CELF2 CUGBP, Elav-like family member 2
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CPE carboxypeptidase E
DAPK1 death-associated protein kinase 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DCN decorin
DEPTOR DEP domain containing MTOR-interacting protein
DES desmin
DHDDS dehydrodolichyl diphosphate synthase
DTX4 deltex 4, E3 ubiquitin ligase
EPAS1 endothelial PAS domain protein 1
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FHL2 four and a half LIM domains 2
FRY furry homolog (Drosophila)
HOPX HOP homeobox
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGF1 insulin-like growth factor 1 (somatomedin C)
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
ITM2C integral membrane protein 2C
KLHL41 kelch-like family member 41
LITAF lipopolysaccharide-induced TNF factor
MAGED2 melanoma antigen family D2
MARCKSL1 MARCKS-like 1
MATN2 matrilin 2
MN1 meningioma (disrupted in balanced translocation) 1
MT1E metallothionein 1E
MTSS1 metastasis suppressor 1
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic
NEB nebulin
NXN nucleoredoxin
PDLIM3 PDZ and LIM domain 3
PEG10 paternally expressed 10
PTGIS prostaglandin I2 (prostacyclin) synthase
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SOX4 SRY (sex determining region Y)-box 4
SPON1 spondin 1, extracellular matrix protein
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STMN1 stathmin 1
THBS1 thrombospondin 1
TMSB15A thymosin beta 15a
TNNC2 troponin C type 2 (fast)
TPM1 tropomyosin 1 (alpha)
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TTC3 tetratricopeptide repeat domain 3
TTN titin
XIST X inactive specific transcript (non-protein coding)
ZMYND11 zinc finger, MYND-type containing 11