BRD-K05396879_15-delta prostaglandin J2_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

106 genes differentially expressed following the BRD-K05396879_15-delta prostaglandin J2_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ATF3 activating transcription factor 3
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFD complement factor D (adipsin)
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLU clusterin
CRCT1 cysteine-rich C-terminal 1
CTH cystathionine gamma-lyase
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP14 dual specificity phosphatase 14
ECM1 extracellular matrix protein 1
EPB41L3 erythrocyte membrane protein band 4.1-like 3
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GLA galactosidase, alpha
GPR137B G protein-coupled receptor 137B
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA4L heat shock 70kDa protein 4-like
HSPH1 heat shock 105kDa/110kDa protein 1
IFRD1 interferon-related developmental regulator 1
KYNU kynureninase
LYPD3 LY6/PLAUR domain containing 3
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MIR22HG MIR22 host gene
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
NPC1 Niemann-Pick disease, type C1
PIR pirin (iron-binding nuclear protein)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
RAB9A RAB9A, member RAS oncogene family
RBM47 RNA binding motif protein 47
RHCG Rh family, C glycoprotein
RRAGD Ras-related GTP binding D
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SERINC5 serine incorporator 5
SFN stratifin
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SPRR2B small proline-rich protein 2B
TUBB2A tubulin, beta 2A class IIa
TXN thioredoxin
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANO1 anoctamin 1, calcium activated chloride channel
BCL2A1 BCL2-related protein A1
CCDC85B coiled-coil domain containing 85B
CCNB2 cyclin B2
CCND1 cyclin D1
CD200 CD200 molecule
CRIP2 cysteine-rich protein 2
CTSH cathepsin H
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
ESR1 estrogen receptor 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GBAS glioblastoma amplified sequence
IL1B interleukin 1, beta
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KRT19 keratin 19, type I
LAMA3 laminin, alpha 3
LAMC2 laminin, gamma 2
LGALS1 lectin, galactoside-binding, soluble, 1
LIPA lipase A, lysosomal acid, cholesterol esterase
MLPH melanophilin
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NT5E 5'-nucleotidase, ecto (CD73)
PBX1 pre-B-cell leukemia homeobox 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLK1 polo-like kinase 1
POSTN periostin, osteoblast specific factor
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RGS2 regulator of G-protein signaling 2
RNASE4 ribonuclease, RNase A family, 4
SDC4 syndecan 4
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPDEF SAM pointed domain containing ETS transcription factor
SULF1 sulfatase 1
TACSTD2 tumor-associated calcium signal transducer 2
TGM2 transglutaminase 2
TMX4 thioredoxin-related transmembrane protein 4
TNC tenascin C
VCAN versican